Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on May 22, 2020.

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ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest version of the e-PLA, namely version 2.3.1, which is available for downloading from e-PLA 2.3.1


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New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Acetyl Heptapeptide-4

Role:
Non-medicinal

NHPID Name:
Impatiens Balsamina Flower Extract

Role:
Non-medicinal

NHPID Name:
Nasturtium Officinale Flower/Leaf Extract

Role:
Non-medicinal

NHPID Name:
Dioctyldodecyl Dodecanedioate

Role:
Non-medicinal

NHPID Name:
Isostearyl Linoleate

Role:
Non-medicinal

NHPID Name:
Citrulline Hydrochloride

Role:
No role

NHPID Name:
Monarda Didyma Oil

Role:
Non-medicinal

NHPID Name:
Algal Protein Concentrate

Role:
Medicinal

NHPID Name:
Anemoside B4

Role:
Medicinal

NHPID Name:
Prosopis Pallida

Role:
Medicinal


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Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

No Changes.


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Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

No Changes.


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Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Carbamide peroxide

New Common Name(s):
Urea peroxide

NHPID Name:
Polihexanide

New Proper Name(s):
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), hydrochloride


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New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
Magnesium peroxide

Old Role:
Medicinal

New Role:
No role

NHPID Name:
DEA-C8-18 Perfluoroalkylethyl Phosphate

Old Role:
Non-medicinal

New Role:
No role

NHPID Name:
AMP-C8-18 Perfluoroalkylethyl Phosphate

Old Role:
Non-medicinal

New Role:
No role

NHPID Name:
TEA-C8-18 Perfluoroalkylethyl Phosphate

Old Role:
Non-medicinal

New Role:
No role

NHPID Name:
Methyl alcohol

Old Role:
Non-medicinal

New Role:
No role


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Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Lauryl Glucoside

Route(s) of Adminstration removed:
Topical

NHPID Name:
Lauryl Glucoside

Non-medicinal Restriction(s) changed:
For buccal, dental or topical use only, when formulated to be non-irritating. For topical use, up to 10% in rinse-off products and up to 8% in leave-on products. For buccal or dental use, up to 8%.

NHPID Name:
Lauryl Glucoside

Restriction Reference removed:
UNAVA

NHPID Name:
Lauryl Glucoside

New Restriction Reference added:
CIR

NHPID Name:
Polyquaternium-10

Non-medicinal Restriction(s) changed:
Detail: For topical use only, up to 1.5%.

NHPID Name:
Polyquaternium-10

Restriction Reference removed:
UNAVA

NHPID Name:
Polyquaternium-10

New Restriction Reference added:
CIR

NHPID Name:
Caprylyl/Capryl Glucoside

New Route(s) of Adminstration added:
Topical

NHPID Name:
Caprylyl/Capryl Glucoside

Non-medicinal Restriction(s) changed:
Detail: For topical use only, up to 0.8% in leave-on products and up to 3% in rinse-off products, when formulated to be non-irritating.

NHPID Name:
Caprylyl/Capryl Glucoside

Restriction Reference removed:
UNAVA

NHPID Name:
Caprylyl/Capryl Glucoside

New Restriction Reference added:
CIR

NHPID Name:
Citrulline

Medicinal Restriction(s) Changed :
Detail: For topical use only.

NHPID Name:
Citrulline

Restriction Reference removed:
UNAVA

NHPID Name:
Citrulline

New Restriction Reference added:
ICID

NHPID Name:
Calcium peroxide

Route(s) of Adminstration removed:
Dental

NHPID Name:
Calcium peroxide

Non-medicinal Restriction(s) changed:
Detail: For buccal, dental, or topical use only, if not contributing to the product's claim(s). The following is applicable to buccal and dental use: Not recommended for children under 12 years of age. The pH of products to be applied to the tooth or teeth must be greater than or equal to 4.0. If a buccal or dental product contains more than the equivalent of 3% hydrogen peroxide, the product must not cause the saliva or soft tissue of the oral cavity to exceed 3% hydrogen peroxide. Duration of use: For prolonged use, consult a health care practitioner. Risk statements: Avoid swallowing the product, and avoid contact with eyes. If irritation (such as redness, swelling, soreness) of the gums or the mouth occurs, discontinue use and consult a health care practitioner.

NHPID Name:
Calcium peroxide

Restriction Reference removed:
NNHPD

NHPID Name:
Calcium peroxide

New Restriction Reference added:
CIH

NHPID Name:
Carbamide peroxide

Medicinal Restriction(s) removed:
General

NHPID Name:
Carbamide peroxide

Route(s) of Adminstration removed:
Dental

NHPID Name:
Carbamide peroxide

Non-medicinal Restriction(s) changed:
Detail: For buccal, dental, or topical use only, if not contributing to the product's claim(s). The following is applicable to buccal and dental use: Not recommended for children under 12 years of age. The pH of products to be applied to the tooth or teeth must be greater than or equal to 4.0. If a buccal or dental product contains more than the equivalent of 3% hydrogen peroxide, the product must not cause the saliva or soft tissue of the oral cavity to exceed 3% hydrogen peroxide. Duration of use: For prolonged use, consult a health care practitioner. Risk statements: Avoid swallowing the product, and avoid contact with eyes. If irritation (such as redness, swelling, soreness) of the gums or the mouth occurs, discontinue use and consult a health care practitioner.

NHPID Name:
Carbamide peroxide

Restriction Reference removed:
NNHPD

NHPID Name:
Carbamide peroxide

New Restriction Reference added:
CIH

NHPID Name:
Sodium Carbonate Peroxide

Route(s) of Adminstration removed:
Dental

NHPID Name:
Sodium Carbonate Peroxide

Non-medicinal Restriction(s) changed:
Detail: For buccal, dental, or topical use only, if not contributing to the product's claim(s). The following is applicable to buccal and dental use: Not recommended for children under 12 years of age. The pH of products to be applied to the tooth or teeth must be greater than or equal to 4.0. If a buccal or dental product contains more than the equivalent of 3% hydrogen peroxide, the product must not cause the saliva or soft tissue of the oral cavity to exceed 3% hydrogen peroxide. Duration of use: For prolonged use, consult a health care practitioner. Risk statements: Avoid swallowing the product, and avoid contact with eyes. If irritation (such as redness, swelling, soreness) of the gums or the mouth occurs, discontinue use and consult a health care practitioner.

NHPID Name:
DEA-C8-18 Perfluoroalkylethyl Phosphate

Non-medicinal Restriction(s) removed:
General

NHPID Name:
AMP-C8-18 Perfluoroalkylethyl Phosphate

Non-medicinal Restriction(s) removed:
General

NHPID Name:
TEA-C8-18 Perfluoroalkylethyl Phosphate

Non-medicinal Restriction(s) removed:
General


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Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Citrulline

New Source Ingredient(s) added:
Citrulline Hydrochloride

NHPID Name:
Calcium peroxide

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Carbamide peroxide

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Carbamide peroxide

Removed NMI purpose(s):
Cosmetic

NHPID Name:
Magnesium peroxide

Modification:
Removed Schedule 1: Mineral

NHPID Name:
Magnesium peroxide

Additional Details changed:
Detail: The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Sodium Carbonate Peroxide

New Additional Details added :
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Sodium perborate

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. /

NHPID Name:
Anemone chinensis

New Source Ingredient(s) added:
root

NHPID Name:
Anemone chinensis

New Sub-ingredient(s) added:
Anemoside B4

NHPID Name:
Anemone chinensis

New Name Reference added:
DNP

NHPID Name:
DEA-C8-18 Perfluoroalkylethyl Phosphate

New Additional Details added :
This substance is subject to the Prohibition of Certain Toxic Substances Regulations, 2012. The Regulations prohibit the manufacture, use, sale, offer for sale or import of certain toxic substances, and products containing them, with a limited number of exemptions.

NHPID Name:
DEA-C8-18 Perfluoroalkylethyl Phosphate

Removed NMI purpose(s):
Emulsifying Agent

NHPID Name:
AMP-C8-18 Perfluoroalkylethyl Phosphate

New Additional Details added :
This substance is subject to the Prohibition of Certain Toxic Substances Regulations, 2012. The Regulations prohibit the manufacture, use, sale, offer for sale or import of certain toxic substances, and products containing them, with a limited number of exemptions.

NHPID Name:
AMP-C8-18 Perfluoroalkylethyl Phosphate

Removed NMI purpose(s):
Emulsion Stabilizer, Solvent, Surfactant

NHPID Name:
TEA-C8-18 Perfluoroalkylethyl Phosphate

New Additional Details added :
This substance is subject to the Prohibition of Certain Toxic Substances Regulations, 2012. The Regulations prohibit the manufacture, use, sale, offer for sale or import of certain toxic substances, and products containing them, with a limited number of exemptions.

NHPID Name:
TEA-C8-18 Perfluoroalkylethyl Phosphate

Removed NMI purpose(s):
Non-medicinal

NHPID Name:
Methyl alcohol

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. .

NHPID Name:
Methyl alcohol

New Toxicity restriction added:
Upper Limit: 30.0 . Units: Milligrams/24 hour . Detail: Permitted daily exposure as residual solvent up to 30 mg/day, equivalent to a concentration limit of 3000 ppm when assuming a product mass of 10 g administered daily. This limit applies to all dosage forms and routes of administration. . Reference: ICH


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Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

No Changes.


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AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


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Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

Modification:
AOAC 2018.11 - Quantitation of Cannabinoids in Cannabis Dried Plant Materials, Concentrates, and Oils


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Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.

RemIng
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