Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on July 02, 2019.

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ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest version of the e-PLA, namely version 2.3.1, which is available for downloading from e-PLA 2.3.1


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New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Glyceryl Hydrogenated Rosinate

Role:
Non-medicinal

NHPID Name:
Polyurethane-32

Role:
Non-medicinal

NHPID Name:
Methylliberine

Role:
Medicinal


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Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

No Changes.


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Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

No Changes.


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Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Arbutin

Removed Proper Name(s):
4-Hydroxyphenyl beta-D-glucopyranoside

NHPID Name:
Arbutin

New Proper Name(s):
4-Hydroxyphenyl-beta-D-glucopyranoside


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New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
Hydroquinone

Old Role:
No role

New Role:
Non-NHP

NHPID Name:
Hydroquinone monoethyl ether

Old Role:
No role

New Role:
Non-NHP

NHPID Name:
tertiary-Butylhydroquinone

Old Role:
No role

New Role:
Non-NHP

NHPID Name:
Arbutin

Old Role:
No role

New Role:
Non-NHP

NHPID Name:
alpha-Arbutin

Old Role:
No role

New Role:
Non-NHP


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Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Hydroquinone monoethyl ether

Non-medicinal Restriction(s) removed:
Flavour Enhancer

NHPID Name:
Hydroquinone monoethyl ether

Restriction Reference removed:
JECFA

NHPID Name:
Hydroquinone monoethyl ether

New Restriction Reference added:
WHO_JECFA

NHPID Name:
tertiary-Butylhydroquinone

New Restriction Reference added:
WHO_JECFA

NHPID Name:
tertiary-Butylhydroquinone

Restriction Reference removed:
JECFA

NHPID Name:
Arbutin

Non-medicinal Restriction(s) removed:
Skin-Conditioning Agent

NHPID Name:
Zein

New Route(s) of Adminstration added:
Topical

NHPID Name:
Zein

New Restriction Reference added:
ICID

NHPID Name:
Zein

New Route(s) of Adminstration added:
Oral

NHPID Name:
Zein

New Restriction Reference added:
KIBBE


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Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Hydroquinone

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient cannot be used in topical natural health products except in accordance with the restrictions set out on the Hotlist unless additional evidence for safety is submitted.

NHPID Name:
Hydroquinone

Medicinal Rationale changed:
Classified as an NHP under Schedule 1 item 2 (isolate) of the Natural Health Products Regulations.

NHPID Name:
Hydroquinone

Modification:
Upper Limit: 2; Units: Percent; Route Of Administration: Topical

NHPID Name:
Hydroquinone

Non-NHP Rationale changed:
Hydroquinone is listed on the Prescription Drug List for human use as follows: Hydroquinone or its derivatives, when sold in a concentration greater than 2% in preparations for topical use on the skin.

NHPID Name:
Hydroquinone monoethyl ether

New Name Reference added:
WHO_JECFA

NHPID Name:
Hydroquinone monoethyl ether

New Additional Details added :
The presence of this ingredient without conditions on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient cannot be used in topical natural health products without the submission of additional evidence for safety.

NHPID Name:
Hydroquinone monoethyl ether

Name Reference removed:
JECFA

NHPID Name:
Hydroquinone monoethyl ether

Non-NHP Rationale changed:
Hydroquinone monoethyl ether is a derivative of hydroquinone, listed on the Prescription Drug List for human use as follows: Hydroquinone or its derivatives, when sold in a concentration greater than 2% in preparations for topical use on the skin.

NHPID Name:
tertiary-Butylhydroquinone

Name Reference removed:
EPA

NHPID Name:
tertiary-Butylhydroquinone

New Name Reference added:
CHEMID

NHPID Name:
tertiary-Butylhydroquinone

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient cannot be used in topical natural health products except in accordance with the restrictions set out on the Hotlist unless additional evidence for safety is submitted.

NHPID Name:
tertiary-Butylhydroquinone

Modification:
Upper limit: 0.7; Units: Milligrams/kilogram body weight/day; Route of Administration: Oral; Detail: Acceptable daily intake up to 0.7 mg/kg bw/day.

NHPID Name:
tertiary-Butylhydroquinone

Modification:
Route Of Administration: Topical; Detail: Up to 0.1%. For topical use only for the purpose of fragrance ingredient

NHPID Name:
tertiary-Butylhydroquinone

Non-NHP Rationale changed:
tertiary-Butylhydroquinone is a derivative of hydroquinone, listed on the Prescription Drug List for human use as follows: Hydroquinone or its derivatives, when sold in a concentration greater than 2% in preparations for topical use on the skin

NHPID Name:
Arbutin

Modification:
Detail: For topical use, up to 1% expressed as hydroquinone equivalents, in formulations designed for discontinuous, brief use followed by rinsing from the skin and hair only.

NHPID Name:
Arbutin

Non-NHP Rationale changed:
Arbutin is a derivative of hydroquinone, listed on the Prescription Drug List for human use as follows: Hydroquinone or its derivatives, when sold in a concentration greater than 2% in preparations for topical use on the skin.

NHPID Name:
alpha-Arbutin

Modification:
Upper Limit: 1.0; Units: Percent

NHPID Name:
alpha-Arbutin

Modification:
Route Of Administration: Topical

NHPID Name:
alpha-Arbutin

Modification:
Detail: For topical use, up to 1% expressed as hydroquinone equivalents, in formulations designed for discontinuous, brief use followed by rinsing from the skin and hair only.

NHPID Name:
alpha-Arbutin

Non-NHP Rationale changed:
alpha-Arbutin is a derivative of hydroquinone, listed on the Prescription Drug List for human use as follows: Hydroquinone or its derivatives, when sold in a concentration greater than 2% in preparations for topical use on the skin.

NHPID Name:
Zein

New NMI Purpose(s):
Skin-Conditioning Agent

NHPID Name:
Zein

New Additional Details added :
For oral use only for the purposes of coating agent and polishing agent.

NHPID Name:
Vitamin D

New Sub-ingredient(s) added:
Fruiting Body


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Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

Modification:
BETAINE / BETAINE HYDROCHLORIDE

Modification:
CHONDROITIN SULFATE

Modification:
CORN AND CALLUS REMOVER

Modification:
ELDER - SAMBUCUS

Modification:
HYDROCORTISONE - Topical

Modification:
GLUCOSAMINE HYDROCHLORIDE

Modification:
LEMON BALM - MELISSA OFFICINALIS

Modification:
PHOSPHATIDYLSERINE

Modification:
SOY FLOUR

Modification:
SOYBEAN EXTRACTS AND ISOLATES

Modification:
THYME - THYMUS VULGARIS - Oral

Modification:
WART REMOVER

Modification:
CHOLINE

Modification:
AMERICAN GINSENG - PANAX QUINQUEFOLIUS


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AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


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Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


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Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.

RemIng
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