Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on July 02, 2019.

ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest version of the e-PLA, namely version 2.3.1, which is available for downloading from e-PLA 2.3.1


New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Glyceryl Hydrogenated Rosinate

Role:
Non-medicinal


NHPID Name:
Polyurethane-32

Role:
Non-medicinal


NHPID Name:
Methylliberine

Role:
Medicinal


Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

No Changes.


Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

No Changes.


Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Arbutin

Removed Proper Name(s):
4-Hydroxyphenyl beta-D-glucopyranoside


NHPID Name:
Arbutin

New Proper Name(s):
4-Hydroxyphenyl-beta-D-glucopyranoside


New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
Hydroquinone

Old Role:
No role

New Role:
Non-NHP


NHPID Name:
Hydroquinone monoethyl ether

Old Role:
No role

New Role:
Non-NHP


NHPID Name:
tertiary-Butylhydroquinone

Old Role:
No role

New Role:
Non-NHP


NHPID Name:
Arbutin

Old Role:
No role

New Role:
Non-NHP


NHPID Name:
alpha-Arbutin

Old Role:
No role

New Role:
Non-NHP


Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Hydroquinone monoethyl ether

Non-medicinal Restriction(s) removed:
Flavour Enhancer


NHPID Name:
Hydroquinone monoethyl ether

Restriction Reference removed:
JECFA


NHPID Name:
Hydroquinone monoethyl ether

New Restriction Reference added:
WHO_JECFA


NHPID Name:
tertiary-Butylhydroquinone

New Restriction Reference added:
WHO_JECFA


NHPID Name:
tertiary-Butylhydroquinone

Restriction Reference removed:
JECFA


NHPID Name:
Arbutin

Non-medicinal Restriction(s) removed:
Skin-Conditioning Agent


NHPID Name:
Zein

New Route(s) of Adminstration added:
Topical


NHPID Name:
Zein

New Restriction Reference added:
ICID


NHPID Name:
Zein

New Route(s) of Adminstration added:
Oral


NHPID Name:
Zein

New Restriction Reference added:
KIBBE


Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Hydroquinone

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient cannot be used in topical natural health products except in accordance with the restrictions set out on the Hotlist unless additional evidence for safety is submitted.


NHPID Name:
Hydroquinone

Medicinal Rationale changed:
Classified as an NHP under Schedule 1 item 2 (isolate) of the Natural Health Products Regulations.


NHPID Name:
Hydroquinone

Modification:
Upper Limit: 2; Units: Percent; Route Of Administration: Topical


NHPID Name:
Hydroquinone

Non-NHP Rationale changed:
Hydroquinone is listed on the Prescription Drug List for human use as follows: Hydroquinone or its derivatives, when sold in a concentration greater than 2% in preparations for topical use on the skin.


NHPID Name:
Hydroquinone monoethyl ether

New Name Reference added:
WHO_JECFA


NHPID Name:
Hydroquinone monoethyl ether

New Additional Details added :
The presence of this ingredient without conditions on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient cannot be used in topical natural health products without the submission of additional evidence for safety.


NHPID Name:
Hydroquinone monoethyl ether

Name Reference removed:
JECFA


NHPID Name:
Hydroquinone monoethyl ether

Non-NHP Rationale changed:
Hydroquinone monoethyl ether is a derivative of hydroquinone, listed on the Prescription Drug List for human use as follows: Hydroquinone or its derivatives, when sold in a concentration greater than 2% in preparations for topical use on the skin.


NHPID Name:
tertiary-Butylhydroquinone

Name Reference removed:
EPA


NHPID Name:
tertiary-Butylhydroquinone

New Name Reference added:
CHEMID


NHPID Name:
tertiary-Butylhydroquinone

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient cannot be used in topical natural health products except in accordance with the restrictions set out on the Hotlist unless additional evidence for safety is submitted.


NHPID Name:
tertiary-Butylhydroquinone

Modification:
Upper limit: 0.7; Units: Milligrams/kilogram body weight/day; Route of Administration: Oral; Detail: Acceptable daily intake up to 0.7 mg/kg bw/day.


NHPID Name:
tertiary-Butylhydroquinone

Modification:
Route Of Administration: Topical; Detail: Up to 0.1%. For topical use only for the purpose of fragrance ingredient


NHPID Name:
tertiary-Butylhydroquinone

Non-NHP Rationale changed:
tertiary-Butylhydroquinone is a derivative of hydroquinone, listed on the Prescription Drug List for human use as follows: Hydroquinone or its derivatives, when sold in a concentration greater than 2% in preparations for topical use on the skin


NHPID Name:
Arbutin

Modification:
Detail: For topical use, up to 1% expressed as hydroquinone equivalents, in formulations designed for discontinuous, brief use followed by rinsing from the skin and hair only.


NHPID Name:
Arbutin

Non-NHP Rationale changed:
Arbutin is a derivative of hydroquinone, listed on the Prescription Drug List for human use as follows: Hydroquinone or its derivatives, when sold in a concentration greater than 2% in preparations for topical use on the skin.


NHPID Name:
alpha-Arbutin

Modification:
Upper Limit: 1.0; Units: Percent


NHPID Name:
alpha-Arbutin

Modification:
Route Of Administration: Topical


NHPID Name:
alpha-Arbutin

Modification:
Detail: For topical use, up to 1% expressed as hydroquinone equivalents, in formulations designed for discontinuous, brief use followed by rinsing from the skin and hair only.


NHPID Name:
alpha-Arbutin

Non-NHP Rationale changed:
alpha-Arbutin is a derivative of hydroquinone, listed on the Prescription Drug List for human use as follows: Hydroquinone or its derivatives, when sold in a concentration greater than 2% in preparations for topical use on the skin.


NHPID Name:
Zein

New NMI Purpose(s):
Skin-Conditioning Agent


NHPID Name:
Zein

New Additional Details added :
For oral use only for the purposes of coating agent and polishing agent.


NHPID Name:
Vitamin D

New Sub-ingredient(s) added:
Fruiting Body


Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

Modification:
BETAINE / BETAINE HYDROCHLORIDE


Modification:
CHONDROITIN SULFATE


Modification:
CORN AND CALLUS REMOVER


Modification:
ELDER - SAMBUCUS


Modification:
HYDROCORTISONE - Topical


Modification:
GLUCOSAMINE HYDROCHLORIDE


Modification:
LEMON BALM - MELISSA OFFICINALIS


Modification:
PHOSPHATIDYLSERINE


Modification:
SOY FLOUR


Modification:
SOYBEAN EXTRACTS AND ISOLATES


Modification:
THYME - THYMUS VULGARIS - Oral


Modification:
WART REMOVER


Modification:
CHOLINE


Modification:
AMERICAN GINSENG - PANAX QUINQUEFOLIUS


AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.

RemIng

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