Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on May 08, 2020.

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ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest version of the e-PLA, namely version 2.3.1, which is available for downloading from e-PLA 2.3.1


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New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
AMP-Acrylates/Vinyl Isodecanoate Crosspolymer

Role:
Non-medicinal

NHPID Name:
Hydroxyethyl Cetyldimonium Phosphate

Role:
Non-medicinal

NHPID Name:
Bis-PEG-10 Dimethicone

Role:
Non-medicinal

NHPID Name:
PPG-24-Glycereth-24

Role:
Non-medicinal

NHPID Name:
Platycarya Strobilacea

Role:
Medicinal

NHPID Name:
Farnesyl Acetate

Role:
Non-medicinal

NHPID Name:
Centella Asiatica Leaf Extract

Role:
Non-medicinal

NHPID Name:
Lactobacillus Ferment Lysate

Role:
Non-medicinal


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Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

No Changes.


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Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

No Changes.


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Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Methylisothiazolinone

Removed Proper Name(s):
Methylisothiazolinone

NHPID Name:
Methylisothiazolinone

New Proper Name(s):
2-Methyl-3(2H)-isothiazolone

NHPID Name:
Methylchloroisothiazolinone

Removed Proper Name(s):
Methylchloroisothiazolinone

NHPID Name:
Methylchloroisothiazolinone

New Proper Name(s):
5-Chloro-2-methyl-3(2H)-isothiazolone

NHPID Name:
Isoquercitrin

New Proper Name(s):
Quercetin-3-O-glucoside


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New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

No Changes.


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Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
DL-Alanine

New Non-medicinal Restriction(s) added:
Allowed Purpose: Skin-Conditioning Agent

NHPID Name:
DL-Alanine

New Non-medicinal Restriction(s) added:
Detail: Up to 0.1%.

NHPID Name:
DL-Alanine

Restriction Reference removed:
UNAVA

NHPID Name:
DL-Alanine

New Restriction Reference added:
CIR

NHPID Name:
DL-Alanine

New Route(s) of Adminstration added:
Oral

NHPID Name:
DL-Alanine

New Non-medicinal Restriction(s) added:
Allowed Purposes: Flavour Enhancer

NHPID Name:
DL-Alanine

New Restriction Reference added:
WHO_JECFA

NHPID Name:
Methylisothiazolinone

Non-medicinal Restriction(s) changed:
For topical use only. Not permitted in leave-on products, and up to 0.0015% in rinse-off products. If methylisothiazolinone (MI) is present in a formulation in combination with methylchloroisothiazolinone (MCI), the cumulative, total concentration of MI and MCI may not exceed 0.0015%.

NHPID Name:
Methylchloroisothiazolinone

New Non-medicinal Restriction(s) added:
New Upper Limit: 0.0015

NHPID Name:
Methylchloroisothiazolinone

New Non-medicinal Restriction(s) added:
New Units: Percent

NHPID Name:
Methylchloroisothiazolinone

Non-medicinal Restriction(s) removed:
For topical use only, For use in combination with methylchloroisothiazolinone: Not permitted in leave-on products. Up to 0.0015% (15 µg/mL or 15 ppm) permitted in rinse-off products.

NHPID Name:
Methylchloroisothiazolinone

New Non-medicinal Restriction(s) added:
For topical use only. Not permitted in leave-on products. Methylchloroisothiazolinone (MCI) is only permitted when present in combination with methylisothiazolinone (MI) in rinse-off products. The cumulative, total concentration of MCI and MI may not exceed 0.0015%.


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Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Anthocyanins

New Source Ingredient(s) added:
Sambucus nigra subsp. canadensis - Fruit

NHPID Name:
Anthocyanins

New Sub-ingredient(s) added:
Anthocyanins

NHPID Name:
DL-Alanine

New NMI Purpose(s):
Skin-Conditioning Agent

NHPID Name:
Methylisothiazolinone

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in topical natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php

NHPID Name:
Methylisothiazolinone

New Additional Details added :
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Methylisothiazolinone

New Method(s) of Preparation added:
Upper Limit: 0.0015, Upper Limit: 0.0015 Units: Percent

NHPID Name:
Methylisothiazolinone

Name Reference removed:
List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient "Hotlist")

NHPID Name:
Methylisothiazolinone

New Name Reference added:
Cosmetic Ingredient Hotlist

NHPID Name:
Methylisothiazolinone

Modification:
Revised CIH reference website title: Cosmetic Ingredient Hotlist

NHPID Name:
Methylisothiazolinone

Modification:
Revised site: Cosmetic Ingredient Hotlist

NHPID Name:
Methylisothiazolinone

Modification:
Removed: Publication Date 2007

NHPID Name:
Methylchloroisothiazolinone

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in topical natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php

NHPID Name:
Methylchloroisothiazolinone

New Additional Details added :
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Methylchloroisothiazolinone

Non-NHP Rationale changed:
A non-NHP because not a naturally occurring substance included in Schedule 1 of the Natural Health Products Regulations.

NHPID Name:
Bifidobacterium animalis subsp. Lactis

New Name Reference added:
DSMZ

NHPID Name:
Bifidobacterium animalis subsp. Lactis

New Method(s) of Preparation added:
Inactivated

NHPID Name:
Isoquercitrin

New Source Material(s) added:
Moringa oleifera-leaf

NHPID Name:
Moringa oleifera

New Sub-ingredient(s) added:
Isoquercitrin

NHPID Name:
Moringa oleifera

New Name Reference added:
JIPBS_4(48)

NHPID Name:
Zinc

New Source Ingredient(s) added:
Zinc Difumarate Monohydrate

NHPID Name:
Colloidal silver

Additional Details changed:
Detail: The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Colloidal silver

New Toxicity restriction added:
Upper Limit: 5.0 Units: Micrograms/kilogram body weight/day

NHPID Name:
Silver

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Silver

New Toxicity restriction added:
Upper Limit: 5.0 Units: Micrograms/kilogram body weight/day

NHPID Name:
Silver Citrate

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Silver Citrate

New Toxicity restriction added:
Upper Limit: 5.0 Units: Micrograms/kilogram body weight/day

NHPID Name:
Silver hydrosol

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Silver hydrosol

New Toxicity restriction added:
Upper Limit: 5.0 Units: Micrograms/kilogram body weight/day

NHPID Name:
Silver sulfate

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. .

NHPID Name:
Silver sulfate

New Additional Details added :
Upper Limit: 5.0 Units: Micrograms/kilogram body weight/day

NHPID Name:
Sodium silver aluminum silicate

New Source Material(s) added:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Sodium silver aluminum silicate

New Toxicity restriction added:
Upper Limit: 5.0 Units: Micrograms/kilogram body weight/day

NHPID Name:
Silver nitrate

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.

NHPID Name:
Silver nitrate

New Toxicity restriction added:
Upper Limit: 5.0 Units: Micrograms/kilogram body weight/day


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Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

No Changes.


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AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


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Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


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Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.

RemIng
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