Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on February 12, 2021.

ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the web-based Product Licence Application (web PLA) form. All new product licence application submissions must use the web PLA form.


New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Gaultheria Fragrantissima Leaf Oil

Role:
Non-medicinal


Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

NHPID Name:
Lotaustralin

Role:
No role


NHPID Name:
Alkyl (C12-15) Benzoate

Role:
Non-medicinal


Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

Old NHPID Name:
Scaphium lychnophorum

New NHPID Name:
Scaphium affine


Old NHPID Name:
Lactobacillus brevis

New NHPID Name:
Levilactobacillus Brevis


Old NHPID Name:
Lactobacillus buchneri

New NHPID Name:
Lentilactobacillus Buchneri


Old NHPID Name:
Lactobacillus curvatus

New NHPID Name:
Latilactobacillus Curvatus


Old NHPID Name:
Lactobacillus farciminis

New NHPID Name:
Companilactobacillus Farciminis


Old NHPID Name:
Lactobacillus fermentum

New NHPID Name:
Limosilactobacillus Fermentum


Old NHPID Name:
Lactobacillus hilgardii

New NHPID Name:
Lentilactobacillus Hilgardii


Old NHPID Name:
Lactobacillus kefiri

New NHPID Name:
Lentilactobacillus Kefiri


Old NHPID Name:
Lactobacillus mucosae

New NHPID Name:
Limosilactobacillus Mucosae


Old NHPID Name:
Lactobacillus panis

New NHPID Name:
Limosilactobacillus Panis


Old NHPID Name:
Lactobacillus paraplantarum

New NHPID Name:
Lactiplantibacillus Paraplantarum


Old NHPID Name:
Lactobacillus pontis

New NHPID Name:
Limosilactobacillus Pontis


Old NHPID Name:
Lactobacillus salivarius

New NHPID Name:
Ligilactobacillus Salivarius


Old NHPID Name:
Lactobacillus sanfranciscensis

New NHPID Name:
Fructilactobacillus Sanfranciscensis


Old NHPID Name:
Lactobacillus paracasei

New NHPID Name:
Lacticaseibacillus Paracasei


Old NHPID Name:
Lactobacillus coryniformis

New NHPID Name:
Loigolactobacillus Coryniformis


Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Caulis Dendrobii

New Proper Name(s):
Dendrobium chrysotoxum


NHPID Name:
Fructus Mori

New Common Name(s):
Sang shen zi


NHPID Name:
Semen Juglandis

New Common Name(s):
Hu tao ren


NHPID Name:
Rhizoma Paridis

New Proper Name(s):
Paris polyphylla


NHPID Name:
Rhizoma Paridis

New Common Name(s):
Yunnan chong lou; Hua chong lou; Zao xiu


NHPID Name:
Semen Sterculiae Lychnophorae

New Proper Name(s):
Scaphium affine


NHPID Name:
Lactobacillus brevis

New Proper Name(s):
Levilactobacillus Brevis


NHPID Name:
Lactobacillus brevis

New Common Name(s):
Levilactobacillus Brevis


NHPID Name:
Lactobacillus buchneri

New Proper Name(s):
Lentilactobacillus Buchneri


NHPID Name:
Lactobacillus buchneri

New Common Name(s):
Lentilactobacillus Buchneri


NHPID Name:
Lactobacillus curvatus

New Proper Name(s):
Latilactobacillus Curvatus


NHPID Name:
Lactobacillus curvatus

New Common Name(s):
Latilactobacillus Curvatus


NHPID Name:
Lactobacillus farciminis

New Proper Name(s):
Companilactobacillus Farciminis


NHPID Name:
Lactobacillus farciminis

New Common Name(s):
Companilactobacillus Farciminis


NHPID Name:
Lactobacillus fermentum

New Proper Name(s):
Limosilactobacillus Fermentum


NHPID Name:
Lactobacillus fermentum

New Common Name(s):
Limosilactobacillus Fermentum


NHPID Name:
Lactobacillus hilgardii

New Proper Name(s):
Lentilactobacillus Hilgardii


NHPID Name:
Lactobacillus hilgardii

New Common Name(s):
Lentilactobacillus Hilgardii


NHPID Name:
Lactobacillus kefiri

New Proper Name(s):
Lentilactobacillus Kefiri


NHPID Name:
Lactobacillus kefiri

New Common Name(s):
Lentilactobacillus Kefiri


NHPID Name:
Lactobacillus mucosae

New Proper Name(s):
Limosilactobacillus Mucosae


NHPID Name:
Lactobacillus mucosae

New Common Name(s):
Limosilactobacillus Mucosae


NHPID Name:
Lactobacillus panis

New Proper Name(s):
Limosilactobacillus Panis


NHPID Name:
Lactobacillus panis

New Common Name(s):
Limosilactobacillus Panis


NHPID Name:
Lactobacillus paraplantarum

New Proper Name(s):
Lactiplantibacillus Paraplantarum


NHPID Name:
Lactobacillus paraplantarum

New Common Name(s):
Lactiplantibacillus Paraplantarum


NHPID Name:
Lactobacillus pontis

New Proper Name(s):
Limosilactobacillus Pontis


NHPID Name:
Lactobacillus pontis

New Common Name(s):
Limosilactobacillus Pontis


NHPID Name:
Lactobacillus salivarius

New Proper Name(s):
Ligilactobacillus Salivarius


NHPID Name:
Lactobacillus salivarius

New Common Name(s):
Ligilactobacillus Salivarius


NHPID Name:
Lactobacillus sanfranciscensis

New Proper Name(s):
Fructilactobacillus Sanfranciscensis


NHPID Name:
Lactobacillus sanfranciscensis

New Common Name(s):
Fructilactobacillus Sanfranciscensis


NHPID Name:
Lactobacillus paracasei

New Proper Name(s):
Lacticaseibacillus Paracasei


NHPID Name:
Lactobacillus paracasei

New Common Name(s):
Lacticaseibacillus Paracasei


NHPID Name:
Lactobacillus coryniformis

New Proper Name(s):
Loigolactobacillus Coryniformis


NHPID Name:
Lactobacillus coryniformis

New Common Name(s):
Loigolactobacillus Coryniformis


NHPID Name:
C12-15 Alkyl Benzoate

Removed Proper Name(s):
Alkyl (C12-15) Benzoate


NHPID Name:
C12-15 Alkyl Benzoate

New Proper Name(s):
Benzoic acid, C12-15 alkyl esters


NHPID Name:
Ammonium Benzoate

Removed Proper Name(s):
Ammonium Benzoate


NHPID Name:
Ethylhexyl hydroxystearate benzoate

Removed Proper Name(s):
Ethylhexyl hydroxystearate benzoate


NHPID Name:
Ethylhexyl hydroxystearate benzoate

New Proper Name(s):
Octadecanoic acid, 12-(benzoyloxy)-, 2-ethylhexyl ester


NHPID Name:
Isopentyl benzoate

Removed Proper Name(s):
Isopentyl benzoate


NHPID Name:
Sodium salicylate

Old Role:
Medicinal & Non-medicinal


NHPID Name:
Wintergreen Oil

Non-medicinal Restriction(s) changed:
Revised Detail: Acceptable daily intake up to 0.5 mg/kg bw/day, expressed as methyl salicylate equivalents.


NHPID Name:
Wintergreen Oil

New Restriction Reference added:
WHO_JECFA


NHPID Name:
Wintergreen Oil

Non-medicinal Restriction(s) changed:
Revised Detail: Up to 1%, expressed as methyl salicylate equivalents.


NHPID Name:
Methyl salicylate

Non-medicinal Restriction(s) changed:
Upper Limit: 1.0 . Units: Percent


NHPID Name:
Sodium salicylate

Non-medicinal Restriction(s) changed:
New Detail: For topical use only, up to 0.5% expressed as salicylic acid equivalents, when formulated to be non-irritating and non-sensitizing.


NHPID Name:
Benzyl alcohol

New Non-medicinal Restriction(s) added:
General Detail: Must be declared as medicinal ingredient in throat lozenges in daily doses at or above 100 mg/day, and in anorectal products in concentrations at or above 1% w/w.


NHPID Name:
Methyl benzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.


New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
Ethyl benzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.



Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Isobutyl benzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.


NHPID Name:
Glyceryl tribenzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.


NHPID Name:
C12-15 Alkyl Benzoate

Non-medicinal Restriction(s) changed:
New Detail: For topical use only.


NHPID Name:
Ammonium Benzoate

Non-medicinal Restriction(s) changed:
Detail: For topical use only, up to 0.5%, expressed as benzoic acid equivalents.


NHPID Name:
Ethylhexyl benzoate

Non-medicinal Restriction(s) changed:
Detail: For topical use only, up to 4%.


NHPID Name:
Ethylhexyl hydroxystearate benzoate

Non-medicinal Restriction(s) changed:
Detail: For topical use only.


NHPID Name:
Geranyl benzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.


NHPID Name:
Glycereth-7 Benzoate

Non-medicinal Restriction(s) changed:
Route Of Administration: Topical . Detail: For topical use only.


NHPID Name:
Hex-3-enyl benzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.


NHPID Name:
Hexyl benzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.


NHPID Name:
Passiflora incarnata

New Sub-ingredient(s) added:
Vitexin


NHPID Name:
Gaultheria fragrantissima

New Name Reference added:
GRIN


NHPID Name:
Gaultheria fragrantissima

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 1 (a plant or a plant material) of the Natural Health Products Regulations.


NHPID Name:
Wintergreen Oil

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 2 (an extract) of the Natural Health Products Regulations.


NHPID Name:
Wintergreen Oil

New NMI Purpose(s):
Fragrance Ingredient


NHPID Name:
Methyl salicylate

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
Methyl salicylate

Toxicity Restriction changed:
Revised Detail: Acceptable daily intake up to 0.5 mg/kg bw/day.


NHPID Name:
Rhizoma Paridis

New Source Material(s) added:
Paris polyphylla - Rhizome


NHPID Name:
Semen Sterculiae Lychnophorae

New Source Material(s) added:
Scaphium affine - Seed


NHPID Name:
Semen Sterculiae Lychnophorae

New Taxonomical Synonym(s) added:
Scaphium lychnophorum


NHPID Name:
Scaphium lychnophorum

New Source Material(s) added:
Scaphium affine - Whole plant


NHPID Name:
Lactobacillus brevis

New Source Material(s) added:
Levilactobacillus Brevis - Whole cell


NHPID Name:
Lactobacillus brevis

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus brevis now being considered as a taxonomical synonym of Levilactobacillus brevis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus brevis or Levilactobacillus brevis, following which Lactobacillus brevis will no longer be available for selection and only represented as a taxonomical synonym of Levilactobacillus brevis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus buchneri

New Source Material(s) added:
Lentilactobacillus Buchneri - Whole cell


NHPID Name:
Lactobacillus buchneri

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus buchneri now being considered as a taxonomical synonym of Lentilactobacillus buchneri. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus buchneri or Lentilactobacillus buchneri, following which Lactobacillus buchneri will no longer be available for selection and only represented as a taxonomical synonym of Lentilactobacillus buchneri. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus curvatus

New Source Material(s) added:
Latilactobacillus Curvatus - Whole cell


NHPID Name:
Lactobacillus curvatus

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus curvatus now being considered as a taxonomical synonym of Latilactobacillus curvatus. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus curvatus or Latilactobacillus curvatus, following which Lactobacillus curvatus will no longer be available for selection and only represented as a taxonomical synonym of Latilactobacillus curvatus. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus farciminis

New Source Material(s) added:
Companilactobacillus Farciminis - Whole cell


NHPID Name:
Lactobacillus farciminis

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus farciminis now being considered as a taxonomical synonym of Companilactobacillus farciminis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus farciminis or Companilactobacillus farciminis, following which Lactobacillus farciminis will no longer be available for selection and only represented as a taxonomical synonym of Companilactobacillus farciminis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus fermentum

New Source Material(s) added:
Limosilactobacillus Fermentum - Whole cell


Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Lactobacillus fermentum

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus fermentum now being considered as a taxonomical synonym of Limosilactobacillus fermentum. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus fermentum or Limosilactobacillus fermentum, following which Lactobacillus fermentum will no longer be available for selection and only represented as a taxonomical synonym of Limosilactobacillus fermentum. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus hilgardii

New Source Material(s) added:
Lentilactobacillus Hilgardii - Whole cell


NHPID Name:
Lactobacillus hilgardii

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus hilgardii now being considered as a taxonomical synonym of Lentilactobacillus hilgardii. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus hilgardii or Lentilactobacillus hilgardii, following which Lactobacillus hilgardii will no longer be available for selection and only represented as a taxonomical synonym of Lentilactobacillus hilgardii. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus kefiri

New Source Material(s) added:
Lentilactobacillus Kefiri - Whole cell


NHPID Name:
Lactobacillus kefiri

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus kefiri now being considered as a taxonomical synonym of Lentilactobacillus kefiri. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus kefiri or Lentilactobacillus kefiri, following which Lactobacillus kefiri will no longer be available for selection and only represented as a taxonomical synonym of Lentilactobacillus kefiri. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly. . .


NHPID Name:
Lactobacillus mucosae

New Source Material(s) added:
Limosilactobacillus Mucosae - Whole cell


NHPID Name:
Lactobacillus mucosae

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus mucosae now being considered as a taxonomical synonym of Limosilactobacillus mucosae. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus mucosae or Limosilactobacillus mucosae, following which Lactobacillus mucosae will no longer be available for selection and only represented as a taxonomical synonym of Limosilactobacillus mucosae. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus panis

New Source Material(s) added:
Limosilactobacillus Panis - Whole cell


NHPID Name:
Lactobacillus panis

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus panis now being considered as a taxonomical synonym of Limosilactobacillus panis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus panis or Limosilactobacillus panis, following which Lactobacillus panis will no longer be available for selection and only represented as a taxonomical synonym of Limosilactobacillus panis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus paraplantarum

New Source Material(s) added:
Lactiplantibacillus Paraplantarum - Whole cell


NHPID Name:
Lactobacillus paraplantarum

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus paraplantarum now being considered as a taxonomical synonym of Lactiplantibacillus paraplantarum. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus paraplantarum or Lactiplantibacillus paraplantarum, following which Lactobacillus paraplantarum will no longer be available for selection and only represented as a taxonomical synonym of Lactiplantibacillus paraplantarum. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus pontis

New Source Material(s) added:
Limosilactobacillus Pontis - Whole cell


NHPID Name:
Lactobacillus pontis

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus pontis now being considered as a taxonomical synonym of Limosilactobacillus pontis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus pontis or Limosilactobacillus pontis, following which Lactobacillus pontis will no longer be available for selection and only represented as a taxonomical synonym of Limosilactobacillus pontis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus salivarius

New Source Material(s) added:
Ligilactobacillus Salivarius - Whole cell


NHPID Name:
Lactobacillus salivarius

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus salivarius now being considered as a taxonomical synonym of Ligilactobacillus salivarius. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus salivarius or Ligilactobacillus salivarius, following which Lactobacillus salivarius will no longer be available for selection and only represented as a taxonomical synonym of Ligilactobacillus salivarius. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus sanfranciscensis

New Source Material(s) added:
Fructilactobacillus Sanfranciscensis - Whole cell


NHPID Name:
Lactobacillus sanfranciscensis

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus sanfranciscensis now being considered as a taxonomical synonym of Fructilactobacillus sanfranciscensis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus sanfranciscensis or Fructilactobacillus sanfranciscensis, following which Lactobacillus sanfranciscensis will no longer be available for selection and only represented as a taxonomical synonym of Fructilactobacillus sanfranciscensis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus paracasei

New Source Material(s) added:
Lacticaseibacillus Paracasei - Whole cell


NHPID Name:
Lactobacillus paracasei

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus paracasei now being considered as a taxonomical synonym of Lacticaseibacillus paracasei. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus paracasei or Lacticaseibacillus paracasei, following which Lactobacillus paracasei will no longer be available for selection and only represented as a taxonomical synonym of Lacticaseibacillus paracasei. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Lactobacillus coryniformis

New Source Material(s) added:
Loigolactobacillus Coryniformis - Whole cell


NHPID Name:
Lactobacillus coryniformis

New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus coryniformis now being considered as a taxonomical synonym of Loigolactobacillus coryniformis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus coryniformis or Loigolactobacillus coryniformis, following which Lactobacillus coryniformis will no longer be available for selection and only represented as a taxonomical synonym of Loigolactobacillus coryniformis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.


NHPID Name:
Sodium salicylate

Modification:
Removed Schedule 1: Isolate


NHPID Name:
Benzyl alcohol

Toxicity Restriction changed:
Revised Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.


NHPID Name:
Methyl benzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Ethyl benzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Isobutyl benzoate

New Source Material(s) added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Glyceryl tribenzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Dipropylene glycol dibenzoate

Removed NMI purpose(s):
Plasticizer


NHPID Name:
Ethylhexyl hydroxystearate benzoate

New CAS Registry Number(s) added:
199277-69-5


NHPID Name:
Geranyl benzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Hex-3-enyl benzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Hexyl benzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Poloxamer 105 Benzoate

New NMI Purpose(s):
Emulsifying Agent; Surfactant - Solubilizing Agent


NHPID Name:
Isopentyl benzoate

New Proper Name(s):
Benzoic acid, isopentyl ester


NHPID Name:
Isopentyl benzoate

Removed Common Name(s):
1-Butanol, 3-methyl-, benzoate; 3-methylbutyl benzoate; Benzoic acid, isopentyl ester; Isopentyl alcohol, benzoate


NHPID Name:
Isopentyl benzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Isopentyl benzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.


NHPID Name:
Isopropyl benzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Isopropyl benzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.


NHPID Name:
Isostearyl benzoate

Non-medicinal Restriction(s) changed:
Route Of Administration: Topical . Detail: For topical use only, up to 1%


NHPID Name:
Laureth-2 benzoate

Non-medicinal Restriction(s) changed:
Route Of Administration: Topical . Detail: For topical use only.


NHPID Name:
Lauryl/Myristyl Benzoate

Non-medicinal Restriction(s) changed:
Detail: For topical use only.


NHPID Name:
Linalyl benzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Linalyl benzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.


NHPID Name:
Phenethyl Benzoate

Non-medicinal Restriction(s) changed:
Detail: For topical use only.


NHPID Name:
Poloxamer 105 Benzoate

Removed NMI purpose(s):
Emulsifying Agent; Lubricant; Solubilizing Agent; Suspending Agent - Nonsurfactant; Wetting Agent


NHPID Name:
Poloxamer 105 Benzoate

Non-medicinal Restriction(s) changed:
Route Of Administration: Topical . Detail: For topical use only.


NHPID Name:
Benzoate de PPG-15 stéaryl éther

Non-medicinal Restriction(s) changed:
Detail: For topical use only.


NHPID Name:
Propyl Benzoate

Removed Proper Name(s):
Propyl Benzoate


NHPID Name:
Propyl Benzoate

New Proper Name(s):
Benzoic acid, propyl ester


NHPID Name:
Propyl Benzoate

Removed Common Name(s):
Benzoic acid, propyl ester; n-propyl benzenecarboxylate; Propyl phenyl methanoate


NHPID Name:
Propyl Benzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ


NHPID Name:
Propyl Benzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only. / Pour usage oral seulement.


NHPID Name:
Propylene glycol dibenzoate

New Toxicity restriction added:
Toxicity Restriction Upper Limit: 5.0 . Units: Milligrams/kilogram body weight/day . Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents. . Reference: GOC_2019_ASSESS_BENZ . .


NHPID Name:
Propylene glycol dibenzoate

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer • Revised Detail: For oral use only.


NHPID Name:
Benzophenone

Removed Proper Name(s):
Benzophenone


NHPID Name:
Benzophenone

New Proper Name(s):
Diphenylmethanone


NHPID Name:
Benzophenone

Removed Common Name(s):
Methanone, diphenyl-


NHPID Name:
Benzophenone

Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer Revised Detail: For oral use only, up to 3.27 ppm.


Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

No Changes.


AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.

RemIng

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