Natural Health Products Ingredients Database
WHAT'S NEW
What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on November 25, 2022.
- Announcements
- New Ingredients
- Removed Ingredients
- Revised NHPID Names
- Revised Proper and Common Names
- New Roles
- Revised Restrictions
- Other Ingredient Modifications
- Monograph Modifications
- AbLS Modifications
- Controlled Vocabulary Modifications
- Homeopathic Ingredient Modifications
- Previous What's New
ANNOUNCEMENTS
The updates to the NHPID listed below apply to the most recent version of the web-based Product Licence Application (web PLA) form. All new product licence application submissions must use the web PLA form.
New Ingredients
In this update, the following non-homeopathic ingredients were added.
NHPID Name:
Cassia Hydroxypropyltrimonium Chloride
Role:
Non-Medicinal
NHPID Name:
Chondroitin Sulfate Oligosaccharides
Role:
Medicinal
NHPID Name:
Propanediol caprylate
Role:
No role
NHPID Name:
Carya Illinoinensis (Pecan) Shell Extract
Role:
Non-medicinal
NHPID Name:
Hydrotalcite
Role:
Medicinal
NHPID Name:
Fish Cartilage Hydrolysate
Role:
Medicinal
NHPID Name:
Silica Caprylyl Silylate
Role:
Non-medicinal
Removed Ingredients
In this update, the following non-homeopathic ingredients were removed.
No Changes.
Revised NHPID Names
In this update, the following non-homeopathic ingredients had their NHPID name revised.
Old NHPID Name:
Dibenzoyl thiamine hydrochloride
New NHPID Name:
Bentiamine hydrochloride
Old NHPID Name:
All-trans retinol
New NHPID Name:
all-trans-Retinol
Old NHPID Name:
Vitamin A acetate
New NHPID Name:
all-trans-Retinyl acetate
Old NHPID Name:
Vitamin A palmitate
New NHPID Name:
all-trans-Retinyl palmitate
Revised Proper and Common Names
In this update, the following non-homeopathic ingredients had their common or proper names revised.
NHPID Name:
Bentiamine hydrochloride
Removed Proper Name(s):
Dibenzoyl thiamine hydrochloride
NHPID Name:
Bentiamine hydrochloride
New Proper Name(s):
O,S-Dibenzoyl thiamine hydrochloride
NHPID Name:
Bentiamine hydrochloride
New Common Name(s):
Bentiamine hydrochloride
NHPID Name:
Sulbutiamine
Removed Proper Name(s):
Sulbutiamine
NHPID Name:
Sulbutiamine
New Proper Name(s):
Thiamine disulfide O,O-diisobutyrate
NHPID Name:
Sulbutiamine
Removed Common Name(s):
Thiamine disulfide O,O-diisobutyrate
NHPID Name:
Sulbutiamine
New Common Name(s):
Sulbutiamine
NHPID Name:
Thiamine Disulfide
New Common Name(s):
Thiamine disulfide
NHPID Name:
Vitamin A
Removed Common Name(s):
Retinol
NHPID Name:
all-trans-Retinol
Removed Proper Name(s):
All-trans retinol
NHPID Name:
all-trans-Retinol
New Proper Name(s):
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
NHPID Name:
all-trans-Retinol
Removed Common Name(s):
All-trans retinol
NHPID Name:
all-trans-Retinol
New Common Name(s):
Retinol
NHPID Name:
all-trans-Retinyl palmitate
Removed Common Name(s):
All-trans retinyl palmitate
NHPID Name:
Conductase
Removed Proper Name(s):
Pyridoxine alpha-Ketoglutarate
NHPID Name:
Conductase
New Common Name(s):
Pyridoxine alpha-ketoglutarate
NHPID Name:
Pyridoxamine
Removed Proper Name(s):
Pyridoxamine
NHPID Name:
Pyridoxamine
New Proper Name(s):
4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol
NHPID Name:
Pyridoxamine 5'-phosphate
Removed Proper Name(s):
Pyridoxamine 5'-phosphate
NHPID Name:
Pyridoxamine 5'-phosphate
New Proper Name(s):
4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol 3-(dihydrogen phosphate)
NHPID Name:
Pyridoxine 5'-phosphate
Removed Proper Name(s):
Pyridoxine 5'-phosphate
NHPID Name:
Pyridoxine 5'-phosphate
New Proper Name(s):
5-Hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate
NHPID Name:
Cyanocobalamin
Removed Proper Name(s):
Cyanocobalamin
NHPID Name:
Cyanocobalamin
New Proper Name(s):
Cobinamide cyanide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole inner salt
NHPID Name:
Vitamin C
Removed Common Name(s):
Ascorbic acid
NHPID Name:
Potassium iodate
Removed Proper Name(s):
Potassium iodate
NHPID Name:
Potassium iodate
New Proper Name(s):
Iodic acid (HIO3) potassium salt (1:1)
NHPID Name:
D-Pantothenic acid
Removed Common Name(s):
D-Pantothenic acid
NHPID Name:
Calcium D-pantothenate
Removed Common Name(s):
Calcium d-pantothenate; Calcium pantothenate; Pantothenic acid calcium salt
NHPID Name:
Dexpanthenol
New Proper Name(s):
(2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
NHPID Name:
Sodium D-pantothenate
Removed Common Name(s):
Pantothenic acid, sodium salt; Sodium pantothenate
New Roles
In this update, the roles of the following non-homeopathic ingredients were changed.
NHPID Name:
Vitamin C
Old Role:
Non-Medicinal
New Role:
No Role
NHPID Name:
Ascorbic acid
Old Role:
No Role
New Role:
Non-Medicinal
NHPID Name:
Sulbutiamine
Old Role:
Medicinal
New Role:
No Role
NHPID Name:
Thiamine diphosphate
Old Role:
Medicinal
New Role:
No Role
NHPID Name:
Vitamin A
Old Role:
Non-Medicinal
New Role:
No Role
NHPID Name:
all-trans-Retinol
Old Role:
No role
New Role:
Non-medicinal
NHPID Name:
Vitamin A acetate
Old Role:
Medicinal
New Role:
No Role
NHPID Name:
all-trans-Retinyl palmitate
Old Role:
Medicinal
New Role:
No Role
NHPID Name:
Pyridoxal
Old Role:
Medicinal
New Role:
No Role
NHPID Name:
Pyridoxal 5'-phosphate
Old Role:
Medicinal
New Role:
No Role
NHPID Name:
Vitamin B12
Old Role:
Non-Medicinal
New Role:
No Role
NHPID Name:
Vitamin B12
Old Role:
No Role
New Role:
Non-NHP
NHPID Name:
Cyanocobalamin
Old Role:
No Role
New Role:
Non-medicinal
NHPID Name:
Methylcobalamin
Old Role:
Medicinal
New Role:
No role
NHPID Name:
Ascorbic acid 2-O-glucoside
Old Role:
Medicinal
New Role:
No Role
NHPID Name:
Manganese (II) ascorbate
Old Role:
Medicinal
New Role:
No Role
NHPID Name:
Zinc ascorbate
Old Role:
Medicinal
New Role:
No Role
NHPID Name:
Potassium iodate
Old Role:
No role
New Role:
Non-medicinal
NHPID Name:
Calcium DL-pantothenate
Old Role:
Non-medicinal
New Role:
No role
NHPID Name:
Dexpanthenol
Old Role:
Medicinal
New Role:
No role
NHPID Name:
D-Pantethine
Old Role:
Medicinal
New Role:
No role
Revised Restrictions
In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.
NHPID Name:
Ascorbic acid 2-O-glucoside
New Route(s) of Adminstration added:
Topical
NHPID Name:
Ascorbic acid 2-O-glucoside
New Non-medicinal Restriction(s) added:
For topical use only, up to 5%.
NHPID Name:
Ascorbic acid
New Route(s) of Adminstration added:
Topical
NHPID Name:
Ascorbic acid
New Non-medicinal Restriction(s) added:
Allowed Purposes: Preservative Antioxidant; Skin-Conditioning Agent
NHPID Name:
Ascorbic acid
New Non-medicinal Restriction(s) added:
Detail:Up to 10%.
NHPID Name:
Ascorbic acid
New Route(s) of Adminstration added:
Oral
NHPID Name:
Ascorbic acid
New Non-medicinal Restriction(s) added:
Allowed Purposes:Preservative Antioxidant
NHPID Name:
Ascorbic acid
New Non-medicinal Restriction(s) added:
Detail:Up to 0.1%.
NHPID Name:
Ascorbic acid
New Non-medicinal Restriction(s) added:
Allowed Purposes:Flavour Enhancer
NHPID Name:
Ascorbic acid
New Non-medicinal Restriction(s) added:
Detail:Up to 8.87 ppm.
NHPID Name:
Hydrolyzed elastin
New Route(s) of Adminstration added:
Topical
NHPID Name:
Hydrolyzed elastin
New Non-medicinal Restriction(s) added:
Detail:For topical use only, up to 5%.
NHPID Name:
Ginkgo biloba
New Non-medicinal Restriction(s) added:
Detail:In order to reduce toxicity, the following must be processed before use as a Traditional Chinese Medicine ingredient: Ginkgo biloba seeds must be either dry-fried or baked at a medium temperature until they turn deep yellow in order to break down ginkgotoxin.
NHPID Name:
Ascorbyl methylsilanol pectinate
New Non-medicinal Restriction(s) added:
Detail:For topical use only.
NHPID Name:
Thiamine diphosphate
New Route(s) of Adminstration added:
Topical
NHPID Name:
Thiamine diphosphate
New Non-medicinal Restriction(s) added:
For topical use only.
NHPID Name:
Thiamine hydrochloride
New Non-medicinal Restriction(s) added:
For topical use only.
NHPID Name:
all-trans-Retinyl palmitate
Route(s) of Adminstration removed:
Oral
NHPID Name:
Pyridoxine
New Route(s) of Adminstration added:
Topical
NHPID Name:
Pyridoxine hydrochloride
New Non-medicinal Restriction(s) added:
Detail:For topical use only.
NHPID Name:
Cyanocobalamin
New Route(s) of Adminstration added:
Topical
NHPID Name:
Potassium iodate
New Route(s) of Adminstration added:
Topical
NHPID Name:
Dexpanthenol
New Non-medicinal Restriction(s) added:
For topical use only, up to 6%.
NHPID Name:
D-Pantethine
New Non-medicinal Restriction(s) added:
For topical use only.
NHPID Name:
Riboflavin
New Route(s) of Adminstration added:
Topical
NHPID Name:
Riboflavin 5'-phosphate sodium
Non-medicinal Restriction(s) changed:
Allowed Purposes: Colour Additive, Skin-Conditioning Agent
NHPID Name:
PEG-15/Lauryl Dimethicone Crosspolymer
New Non-medicinal Restriction(s) added:
Skin-Conditioning Agent
Other Ingredient Modifications
In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.
NHPID Name:
Ginkgo biloba
New Additional Details added :
Ginkgolic acids: Testing must be performed to ensure that the finished product meets the toxicity restrictions for Ginkgolic acids of not more than 5 ppm [USP 43-NF38; Ph.eur. 11th edition 2022 (11.1); Boateng and Yang 2022; Boateng 2022].
NHPID Name:
Ginkgo biloba-Phosphatidylcholine complex
New Additional Details added :
Ginkgolic acids: Testing must be performed to ensure that the finished product meets the toxicity restrictions for Ginkgolic acids of not more than 5 ppm [USP 43-NF38; Ph.eur. 11th edition 2022 (11.1); Boateng and Yang 2022; Boateng 2022].
NHPID Name:
Folium Ginkgo
Additional Details changed:
Ginkgolic acids: Testing must be performed to ensure that the finished product meets the toxicity restrictions for Ginkgolic acids of not more than 5 ppm [USP 43-NF38; Ph.eur. 11th edition 2022 (11.1); Boateng and Yang 2022; Boateng 2022].
NHPID Name:
Semen Ginkgo
Additional Details changed:
Ginkgolic acids: Testing must be performed to ensure that the finished product meets the toxicity restrictions for Ginkgolic acids of not more than 5 ppm [USP 43-NF38; Ph.eur. 11th edition 2022 (11.1); Boateng and Yang 2022; Boateng 2022].
NHPID Name:
Harpagoside
New Source Material(s) added:
Harpagophytum procumbens ( Parts: Secondary root tuber )
NHPID Name:
Harpagophytum procumbens
Modification:
Added Source Material Constituent(s): Secondary root tuber
NHPID Name:
Thiamine
New Source Ingredient(s) added:
Thiamine disulfide
NHPID Name:
Sulbutiamine
Source Ingredient(s) removed:
Thiamine Disulfide
NHPID Name:
Thiamine Disulfide
Sub-ingredient(s) removed:
Sulbutiamine
NHPID Name:
Thiamine Disulfide
New Sub-ingredient(s) added:
Thiamine
NHPID Name:
all-trans-Retinol
New Additional Details added :
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in topical natural health products, unless additional evidence for safety is submitted.
NHPID Name:
Vitamin B12
Additional Details removed:
Vitamin B12 with Intrinsic Factor Concentrate is a non-NHP (as a combination) as it is listed in the Prescription Drug List (PDL).
NHPID Name:
Carbon dioxide
Removed NMI purpose(s):
PH Adjuster
NHPID Name:
Carbon dioxide
New NMI Purpose(s):
Carbonating Agent
NHPID Name:
Octanoic acid
New Sub-ingredient(s) added:
Propanediol caprylate
NHPID Name:
Hydrolyzed collagen type II
Source Material(s) removed:
Leucoraja naevus (Parts: Cartilage) ; Raja brachyura (Parts: Cartilage) ; Raja clavata (Parts: Cartilage)
Monograph Modifications
In this update, the following single ingredient or product monographs were added or modified.
Modification:
Secondary Sunscreen Monograph
Modification:
Primary Sunscreen Monograph
Modification:
Stem bromelain
Modification:
Fruit bromelain
AbLS Modifications
In this update, the following abbreviated labelling standards were added or modified.
No Changes.
Controlled Vocabulary Modifications
In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.
Modification:
Hydrosol: Water charged, by distillation, with volatile plant principles.
Modification:
Capsule, liquid filled: solid preparation with hard or soft shell, of variable shape and capacity, usually containing a single dose of active ingredients for oral administration. The active ingredients are dissolved or suspended in a liquid vehicle.
Homeopathic Ingredient Modifications
In this update, the following homeopathic ingredients were added or modified.
No Changes.
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