Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on March 28, 2024.

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ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the web-based Product Licence Application (web PLA) form. All new product licence application submissions must use the web PLA form.


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New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Physalis Philadelphica Fruit

Role:
Non-medicinal

NHPID Name:
Tasmannia Lanceolata Leaf Extract

Role:
Non-medicinal

NHPID Name:
Acetyl Dipeptide-31 Amide

Role:
Non-medicinal

NHPID Name:
Cetyl Glyceryl Ether

Role:
Non-medicinal

NHPID Name:
Chlorhexidine Dihydrochloride

Role:
Non-medicinal; Non-NHP

NHPID Name:
Physalis Philadelphica

Role:
Medicinal

NHPID Name:
Sea Buckthorn Fruit Oil

Role:
Medicinal


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Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

NHPID Name:
Butyl methoxydibenzoylmethane

Role:
Non-medicinal


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Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

No Changes.


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Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Butyloctyl salicylate

New Proper Name(s):
Benzoic acid, 2-hydroxy, 2-butyloctyl ester

NHPID Name:
Harpagoside

Removed Proper Name(s):
Harpagoside

NHPID Name:
Harpagoside

New Proper Name(s):
(1S-(1alpha,4aalpha,5alpha,7alpha(E),7aalpha))-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(c)pyran-1-yl-beta-D-glucopyranoside

NHPID Name:
Harpagoside

Removed Common Name(s):
(1S-(1alpha,4aalpha,5alpha,7alpha(E),7aalpha))-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(c)pyran-1-yl-beta-D-glucopyranoside ; [6,7-dihydroxy-9-methyl-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]non-4-en-9-yl] 3-phenylprop-2-enoate

NHPID Name:
5'-Uridylic acid

New Common Name(s):
Uridine monophosphate

NHPID Name:
Avobenzone

New Common Name(s):
Butyl methoxydibenzoylmethane

NHPID Name:
Nicotinamide Mononucleotide

New Common Name(s):
Nicotinamide mononucleotide

NHPID Name:
Nicotinamide Mononucleotide

Removed Common Name(s):
Nicotinamide Mononucleotide

NHPID Name:
Melissa officinalis

New Common Name(s):
Lemon balm


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New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
Avobenzone

Old Role:
Non-NHP


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Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Butyloctyl salicylate

Non-medicinal Restriction(s) changed:
For topical use, up to 5%, in sunscreens only.


NHPID Name:
Polylysine

New Non-medicinal Restriction(s) added:
For topical use only for the purpose of Hair-Conditioning Agent.

NHPID Name:
Massa Medicata Fermentata

Route(s) of Adminstration removed:
Oral

NHPID Name:
Massa Medicata Fermentata

Medicinal Restriction(s) removed:
In order to reduce toxicity, the fruit of Xanthium sibiricum and the seeds of Prunus armeniaca must be processed before use as medicinal ingredients in Massa Medicata Fermentata: Xanthium sibiricum fruit must have the spines removed and be stir-baked. The skin of Prunus armeniaca seeds must be removed and the seeds stir-baked in order to break down amygdalin, a cyanogenic glycoside.

NHPID Name:
Massa Medicata Fermentata

New Medicinal Restriction(s) added :
In order to reduce toxicity, the seeds of Prunus armeniaca must be processed before use as medicinal ingredients in Massa Medicata Fermentata: The skin of Prunus armeniaca seeds must be removed and the seeds stir-baked in order to break down amygdalin, a cyanogenic glycoside.

NHPID Name:
Pinelliae Fermentata

Medicinal Restriction(s) removed:
The 5 ingredients of Pinelliae Fermentata (Rhizoma Pinelliae Preparatum cum Alumine, Alumen, Massa Medicata Fermentata, fresh ginger juice, wheat flour) are listed in the State Drug Standard (SDS) Banxia qu monograph WS3-B-1919-95 (in Chinese), available at: http://www.pharmnet.com.cn/search/detail--32--6815.htmlA cover letter listing each ingredient, its source material, and its processing method will need to be submitted with the Product License Application Form.

NHPID Name:
Pinelliae Fermentata

New Medicinal Restriction(s) added :
As this ingredient is a Traditional Chinese Medicine (TCM) ingredient, it may only be used in accordance with the conditions of use outlined in Traditional Chinese Medicine (TCM) referenced texts (e.g. methods of preparations, source materials, doses, directions for use, durations of use, combinations of medicinal ingredients, risk statements, and the theory of TCM). Pinelliae Fermentata must be prepared according to the State Drug Standard (SDS) Banxia qu monograph WS3-B-1919-95 available at: http://www.pharmnet.com.cn/search/detail--32--6815.html (in Chinese). When submitting a Product Licence Application (PLA) form including Pinelliae Fermentata, all ingredients of Pinelliae Fermentata must be listed a source materials. Note that the source material Pinellia ternata tuber is the TCM pharmacopeial substance Rhizoma Pinelliae Preparatum cum Alumine which is processed with 8% Alumine. Also note that Pinelliae Fermentata includes the TCM pharmacopeial substance Alumen (Bai fan) which cannot be included as a source ingredient on the PLA form, but must nonetheless be included in Pinelliae Fermentata. As Massa Medicata Fermentata is one of the ingredients in Pinelliae Fermentata, all 7 ingredients of Massa Medicata Fermentata must also be listed a source materials. Note that wheat bran and wheat flour included in Massa Medicata Fermentata, as well as additional wheat flour added to Pinelliae Fermentata, can all be represented as one source material (Triticum aestivum husk and seed).

NHPID Name:
Pinelliae Fermentata

New Medicinal Restriction(s) added :
Artemisia species contain thujone. For adults, the upper limit for total daily intake of thujone from health products is 6 mg. Product licence applications for oral products should include a copy of a certificate of analysis or any other equivalent document demonstrating that the thujone content of a daily dose of the product is acceptable. Because thujone content of the herbal materials can vary, the thujone content should be determined for each batch during production of the product.

NHPID Name:
Pinelliae Fermentata

New Medicinal Restriction(s) added :
In order to reduce toxicity, the seeds of Prunus armeniaca must be processed before use as medicinal ingredients in Massa Medicata Fermentata: The skin of Prunus armeniaca seeds must be removed and the seeds stir-baked in order to break down amygdalin, a cyanogenic glycoside.


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Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Harpagoside

New Source Material(s) added:
Harpagophytum zeyheri (Parts: Root)

NHPID Name:
Harpagophytum zeyheri

Modification:
New Source material Constituent(s): Root

NHPID Name:
Harpagophytum zeyheri

New Sub-ingredient(s) added:
Harpagoside

NHPID Name:
Uridine

New Source Ingredient(s) added:
5'-Uridylic acid

NHPID Name:
5'-Uridylic acid

New Sub-ingredient(s) added:
Uridine

NHPID Name:
Cod Liver Oil

Modification:
Removed Included Genus Species: Melanogrammus aeglefinus; Gadus chalcogrammus; Arctogadus glacialis; Gadus macrocephalus; Gadus morhua; Gadus ogac; Pollachius virens

NHPID Name:
Cod Liver Oil

New Group organism(s) added:
Gadidae

NHPID Name:
Massa Medicata Fermentata

Source Material(s) removed:
Artemisia annua (Part: Whole plant) ; Persicaria hydropiper (Part: Whole plant) ; Xanthium sibiricum (Part: Whole plant)

NHPID Name:
Massa Medicata Fermentata

New Source Material(s) added:
Artemesia annua (Part: Herb top) ; Persicaria hydropiper (Part: Herb top) ; Xanthium sibiricum (Part: Leaf)

NHPID Name:
Massa Medicata Fermentata

New Method(s) of Preparation added:
Fermentation

NHPID Name:
Massa Medicata Fermentata

Method(s) of Preparation removed:
Decoction ; Decoction concentrate ; Dry ; Extract dry ; Powdered

NHPID Name:
Massa Medicata Fermentata

Additional Details removed:
The six ingredients of Massa Medicata Fermentata are listed in the State Drug Standard (SDS) Shenqu monograph WS3-B-3555-98 (in Chinese), available at: http://www.newdruginfo.com/ypbz/zybb/bbzl0109.htm. These six ingredients must be displayed as source materials in the web PLA form.

NHPID Name:
Massa Medicata Fermentata

New Additional Details added :
As this ingredient is a Traditional Chinese Medicine (TCM) ingredient, it may only be used in accordance with the conditions of use outlined in Traditional Chinese Medicine (TCM) referenced texts (e.g. methods of preparations, source materials, doses, directions for use, durations of use, combinations of medicinal ingredients, risk statements, and the theory of TCM). Massa Medicata Fermentata must be prepared according to the State Drug Standard (SDS) Liu Shen Qu monograph WS3-B-3555-98 available at http://www.newdruginfo.com/ypbz/zybb/bbzl0109.htm (in Chinese). When submitting a Product Licence Application form including Massa Medicata Fermentata, all 7 ingredients of Massa Medicata Fermentata must be listed a source materials. Note that wheat bran and wheat flour can be represented as one source material (Triticum aestivum husk and seed).

NHPID Name:
Pinelliae Fermentata

Group organism(s) removed:
Pinelliae Fermentata Ingredients

NHPID Name:
Pinelliae Fermentata

Modification:
Removed Parts: Whole

NHPID Name:
Pinelliae Fermentata

New Source Material(s) added:
Pinellia ternata (Part: Tuber) ; Artemisia annua (Part: Herb top) ; Persicaria hydropiper (Part: Herb top) ; Prunus armeniaca ((Part: Seed) ; Triticum aestivum (Part: Seed , Husk) ; Vigna umbellata (Part: Seed) ; Xanthium sibiricum (Part: Leaf); Zingiber officinale (Part: rhizome)

NHPID Name:
Pinelliae Fermentata

Method(s) of Preparation removed:
Decoction; Decoction concentrate; Extract dry; Juice powdered

NHPID Name:
Pinelliae Fermentata

New Method(s) of Preparation added:
Fermentation


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Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

Modification:
Turmeric - Curcuma Longa - Oral

Modification:
L-Arginine

Modification:
Joint Health Products

Modification:
Willow bark

Modification:
Grape seed extract

Modification:
Caffeine

Modification:
Chaste Tree - Vitex Agnus-castus

Modification:
Fruit Bromelain/Stem Bromelain

Modification:
Cod Liver Oil

Modification:
Creatine Monohydrate

Modification:
Fish Oil

Modification:
Fixed Oil Products - Oral

Modification:
Hydrolyzed Collagen


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AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


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Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


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Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.

RemIng
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