Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on August 28, 2012.

ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent versions of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest versions of the e-PLA, namely versions 1.4.4 and 2.0.1. Version 1.4.4, known as the Cfgm ePLA, is dedicated to applications of type Compendial from generated monographs (Cfgm), which are used when attesting to a generated single ingredient monograph. Version 2.0.1 is for all application types except for Compendial from generated monographs. The forms are available for downloading from http://www.hc-sc.gc.ca/dhp-mps/prodnatur/applications/online-enligne/guidance-reference-eng.php.


New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Calcium nitrate

Role:
NA


NHPID Name:
Calcite

Role:
NA


NHPID Name:
Picea Abies Leaf Oil

Role:
Medicinal and Non-medicinal


NHPID Name:
Rubus Chamaemorus Seed Oil

Role:
Non-medicinal


NHPID Name:
Callitris Introtropica Wood Oil

Role:
Non-medicinal


NHPID Name:
Fish Protein Hydrolysate

Role:
Medicinal


NHPID Name:
Periostracum Serpentis

Role:
Medicinal


NHPID Name:
Rhizoma Bolbostematis

Role:
Medicinal


NHPID Name:
Vinpocetine

Role:
Medicinal


NHPID Name:
Caulis Dendrobii

Role:
Medicinal


NHPID Name:
Lapis Micae Aureus

Role:
Medicinal


NHPID Name:
Ext. D&C Violet No. 2

Role:
Non-medicinal


Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

NHPID Name:
Radix Ligustici Chuanxiong

Role:
Medicinal


NHPID Name:
Green 5

Role:
Non-medicinal


NHPID Name:
Red 6

Role:
Non-medicinal


NHPID Name:
Red 33

Role:
Non-medicinal


NHPID Name:
Violet 2

Role:
Non-medicinal


Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

Old NHPID Name:
Medium chain triglycerides

New NHPID Name:
Medium-chain triglycerides


Old NHPID Name:
Bergamot Oil Coldpressed

New NHPID Name:
Bergamot Essential Oil


Old NHPID Name:
FD&C Blue No. 1 aluminum lake

New NHPID Name:
FD&C Blue No. 1 Aluminum Lake


Old NHPID Name:
Red 30 Lake

New NHPID Name:
D&C Red No. 30 Aluminum Lake


Old NHPID Name:
Red 7 Lake

New NHPID Name:
D&C Red No. 7 Aluminum Lake


Old NHPID Name:
Red 33 Lake

New NHPID Name:
D&C Red No. 33 Aluminum Lake


Old NHPID Name:
CI 18965

New NHPID Name:
C.I. 18965


Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Medium-chain triglycerides

New Proper Name(s):
Medium-chain triglycerides


NHPID Name:
Medium-chain triglycerides

Removed Proper Name(s):
Medium chain triglycerides


NHPID Name:
Dendrobium nobile

Removed Common Name(s):
Dendrobium; Shihu


NHPID Name:
Bergamot Essential Oil

Removed Proper Name(s):
Citrus aurantium


NHPID Name:
Bergamot Essential Oil

New Proper Name(s):
Citrus bergamia


NHPID Name:
Bergamot Essential Oil

Removed Common Name(s):
Neroli bigarde; Bergamot Oil Coldpressed


NHPID Name:
Bergamot Essential Oil

New Common Name(s):
Bergamot Essential Oil; Bergamot Essential Oil Coldpressed


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Fruit Oil

Removed Proper Name(s):
Citrus aurantium


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Fruit Oil

New Proper Name(s):
Citrus bergamia


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Fruit Oil

Removed Common Name(s):
Bergamot Oil; Citrus Aurantium Bergamia (Bergamot) Fruit Oil


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Fruit Oil

New Common Name(s):
Citrus Aurantium Bergamia (Bergamot) Fruit Essential Oil


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Leaf Oil

Removed Proper Name(s):
Citrus aurantium


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Leaf Oil

New Proper Name(s):
Citrus bergamia


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Leaf Oil

Removed Common Name(s):
Citrus Aurantium Bergamia (Bergamot) Leaf Oil


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Leaf Oil

New Common Name(s):
Citrus Aurantium Bergamia (Bergamot) Leaf Essential Oil


NHPID Name:
Rhizoma Chuanxiong

Removed Proper Name(s):
Ligusticum sinense


NHPID Name:
Rhizoma Chuanxiong

New Proper Name(s):
Ligusticum sinense cv. chuanxiong


NHPID Name:
Alizarin cyanine green F

New Common Name(s):
C.I. 61570, D&C Green No. 5


NHPID Name:
Lithol Rubin B

New Common Name(s):
D&C Red No. 6, Lithol Rubin B


NHPID Name:
Lithol Rubin B Ca

New Common Name(s):
D&C Red No. 7, Lithol Rubin B Ca


NHPID Name:
D&C Red No. 7 Aluminum Lake

Removed Proper Name(s):
Red 7 Lake


NHPID Name:
D&C Red No. 7 Aluminum Lake

New Proper Name(s):
D&C Red No. 7 Aluminum Lake


NHPID Name:
C.I. Acid Red 33, disodium salt

New Common Name(s):
Acid Fuchsin D, C.I. 17200, D&C Red No. 33


NHPID Name:
D&C Red No. 33 Aluminum Lake

Removed Proper Name(s):
Red 33 Lake


NHPID Name:
D&C Red No. 33 Aluminum Lake

New Proper Name(s):
D&C Red No. 33 Aluminum Lake


NHPID Name:
D&C Violet No. 2

New Proper Name(s):
D&C Violet No. 2


NHPID Name:
D&C Violet No. 2

Removed Common Name(s):
Acid violet 43, C.I. No. 60730


NHPID Name:
D&C Violet No. 2

New Common Name(s):
C.I. 60725


NHPID Name:
Pigment Yellow 13

Removed Common Name(s):
CI 21100


NHPID Name:
Pigment Yellow 13

New Common Name(s):
C.I. 21100


NHPID Name:
C.I. 18965

Removed Proper Name(s):
CI 18965


NHPID Name:
C.I. 18965

New Proper Name(s):
Acid yellow 17


NHPID Name:
C.I. 18965

Removed Common Name(s):
Food Yellow 5


NHPID Name:
C.I. 18965

New Common Name(s):
C.I. 18965, Acid yellow 17


NHPID Name:
Copper phthalocyanine

Removed Common Name(s):
CI 74160


NHPID Name:
Copper phthalocyanine

New Common Name(s):
C.I. 74160


NHPID Name:
D&C Red No. 36

Removed Common Name(s):
C.I. No. 12085


NHPID Name:
D&C Red No. 36

New Common Name(s):
C.I. 12085


NHPID Name:
Fast Green FCF

Removed Common Name(s):
C.I. No. 42053


NHPID Name:
Fast Green FCF

New Common Name(s):
C.I. 42053


NHPID Name:
Iron Oxides

Removed Common Name(s):
CI 77491, CI 77492, CI 77499


NHPID Name:
Iron Oxides

New Common Name(s):
C.I. 77491, C.I. 77492, C.I. 77499


NHPID Name:
Zinc ascorbate

New Proper Name(s):
L-Ascorbic acid, zinc salt


NHPID Name:
Magnesium Phosphate, tribasic

New Common Name(s):
Magnesium phosphate anhydrous


NHPID Name:
Magnesium phosphate tribasic pentahydrate

New Common Name(s):
Magnesium phosphate pentahydrate


New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

No Changes.


Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Fragaria Chiloensis (Strawberry) Fruit Juice

Route(s) of Adminstration removed:
Topical


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Fruit Oil

New Route(s) of Adminstration added:
Topical


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Leaf Oil

New Route(s) of Adminstration added:
Topical


NHPID Name:
Lithol Rubin B

New Non-medicinal Restriction(s) added:
Colouring agent only. In oral products, the combined total of D&C Red No. 6 and D&C Red No. 7 must not exceed 5 milligrams per daily dose of the product.


NHPID Name:
Lithol Rubin B Ca

New Non-medicinal Restriction(s) added:
Colouring agent only. In oral products, the combined total of D&C Red No. 6 and D&C Red No. 7 must not exceed 5 milligrams per daily dose of the product.


NHPID Name:
C.I. Acid Red 33, disodium salt

New Non-medicinal Restriction(s) added:
Colouring agent only. In oral products, up to 0.75 mg per day.


NHPID Name:
D&C Violet No. 2

New Route(s) of Adminstration added:
Topical


NHPID Name:
D&C Violet No. 2

New Non-medicinal Restriction(s) added:
Topical use only


NHPID Name:
Pigment Yellow 13

New Route(s) of Adminstration added:
Topical


NHPID Name:
Pigment Yellow 13

New Non-medicinal Restriction(s) added:
Topical use only


NHPID Name:
D&C Red No. 36

New Non-medicinal Restriction(s) added:
In oral products, up to 1.0 mg per day, unless additional evidence for safety is submitted.


NHPID Name:
Iron Oxides

New Non-medicinal Restriction(s) added:
In oral products, up to 5 mg per day calculated as elemental iron


Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Fragaria Chiloensis (Strawberry) Fruit Juice

New NMI Purpose(s):
Skin-Conditioning Agent


NHPID Name:
Medium-chain triglycerides

New NMI Purpose(s):
Filler; Lubricant


NHPID Name:
Carthamus tinctorius

Additional Details changed:
A transgenetic form of Carthamus tinctorius cannot be a medicinal ingredient as a NHP. Drugs obtained by recombinant DNA procedures are listed in the Schedule D of the Food and Drugs Act. Schedule D substances are excluded from NHP regulations; therefore, drugs obtained by recombinant DNA procedures, including transgenic forms of any organisms, are not NHPs.


NHPID Name:
D&C Red No. 27 Aluminum Lake

Toxicity Restriction changed:
Acceptable daily intake is up to 1.25 mg/kg body weight for Tetrachlorotetrabromofluorescein and its derivatives, expressed as Tetrachlorotetrabromofluorescein (Environment Canada and Health Canada, http://www.ec.gc.ca/ese-ees/default.asp?lang=En&n=23C03477-1). Tolerable weekly intake for aluminium and its salts, is up to 1 mg/kg body weight, expressed as aluminium. (Scientific Opinion on the re-evaluation of Erythrosine (E 127) as a food additive, EFSA Journal 9(1):1854, 2011, http://www.efsa.europa.eu/en/efsajournal).


NHPID Name:
Magnesium

New Source Material(s) added:
Magnesium aspartate dihydrate; Magnesium aspartate tetrahydrate; L-Aspartic acid, magnesium salt (2:1); Magnesium aspartate hydrochloride trihydrate


NHPID Name:
Phytosterols

New Source Ingredient(s) added:
Tall oil


NHPID Name:
Bergamot Essential Oil

Method(s) of Preparation removed:
Oil, Essential (enfleurage) , Oil, Essential (enfleurage) Standardised , Oil, Essential (expression) , Oil, Essential (expression) Standardised , Oil, Essential (other methods of preparation) , Oil, Essential (other methods of preparation) Standardised , Oil, Essential (water steam distillation) , Oil, Essential (water steam distillation) Standardised


NHPID Name:
Bergamot Essential Oil

New Method(s) of Preparation added:
Oil, Essential (expression) , Oil, Essential (expression) Standardised


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Fruit Oil

New Additional Details added :
Topical use only.


NHPID Name:
Citrus Aurantium Bergamia (Bergamot) Leaf Oil

New Additional Details added :
Topical use only.


NHPID Name:
Pigment Yellow 13

New CAS Registry Number(s) added:
5102-83-0


NHPID Name:
C.I. 18965

New CAS Registry Number(s) added:
6359-98-4


NHPID Name:
Fast Green FCF

Toxicity Restriction removed:
External or internal use in pharmaceutical dosage forms (Part C.01.040.2)


NHPID Name:
Fast Green FCF

New Toxicity restriction added:
Acceptable daily intake up to 25 mg/kg body weight daily


NHPID Name:
Iron Oxides

New Toxicity restriction added:
Acceptable daily intake up to 0.5 mg/kg body weight daily


NHPID Name:
Protodioscin

CAS Registry Number(s) removed:
55056-80-9


NHPID Name:
Protodioscin

Name Reference removed:
ICID


NHPID Name:
Protodioscin

New Name Reference added:
J_PHARM_SCI_90(1752)


NHPID Name:
Protodioscin

New Source Material(s) added:
Tribulus terrestris (Part: Root)


NHPID Name:
Eicosapentaenoic acid

New Source Material(s) added:
Schizochytrium spp. (Parts: Whole)


Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

No Changes.


AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.


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