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Drugs and Health Products

Nosodes

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredients.

Notes
  • Text in parentheses is additional optional information which can be included on the PLA and product label at the applicant's discretion.
  • The solidus (/) indicates that the terms and/or the statements are synonymous. Either term or statement may be selected by the applicant.
  • Use of the electronic Product License Application form (ePLA) is not possible for products associated with this monograph.

Date

July 16, 2015

Proper name(s) and Common name(s)

Proper name(s) Common name(s)
Anthracinum; Bacillus anthracis Anthracinum; Bacillus anthracis; Bacteridium anthracis
Aspergillus niger Aspergillus niger
Bacille of Morgan; Morganella morgannii Bacille of Morgan; Morgan; Morganella morganii
Bacillinum pulmo Bacillinum pulmo
BCG BCG
Botulinum Botulinum; Clostridium botulinum
Calcarea renalis Calcarea renalis; Lapis renalis; Renal calculi
Candida albicans Candida albicans; Monilla albicans
Candida parapsilosis Candida parapsilosis; Candida parakrusei; Monilla parapsilosis
Carcinosin Carcinosin
Chlamydia trachomatis Chlamydia trachomatis; Chlamydozoon trachomatis; Rickettsia trachomae; Rickettsia trachomatis
Colibacillinum cum natrum muriaticum Colibacillinum cum natrum muriaticum; Escherichia coli in isotonic sodium chloride solution
Ophiocordyceps sinensis Ophiocordyceps sinensis; Cordyceps; Chinese Caterpillar Fungus; Dong Chong Xia Cao
Coxsackie Coxsackie
Diphtherinum Diphtherinum; Potentized diphtheritic microbe; Corynebacterium diphtheriae
Eberthinum Eberthinum; Salmonella typhosa; Eberthella typhosa
Enterococcinum Enterococcinum; Mixed Enterococcus/Streptococcus stock
Epstein-Barr Epstein-Barr Virus; HHV-4
Friedlander Bacillus of Pneumonia; Klebsiella pneumoniae Friedlander Bacillus of Pneumonia; Klebsiella pneumoniae; Bacillus mucosus capsulatus; Friedlander; Pneumobacillus
Herpes simplex Herpes Simplex
Herpes zoster Herpes Zoster
Hippozaeninum; Hippozaenin Hippozaeninum; Hippozaenin; Farcin; Farcine; Glanderin; Glanderine; Mallein
Influenzinum; Influenza virus Influenzinum; Influenza virus; Vaccinum influenzae inactivum; Influenza; Inactivated influenza
Lyssin Lyssin; Hydrophobinum
Malandrinum Malandrinum
Malaria officinalis Malaria officinalis
Marmorek Marmorek
Medorrhinum Medorrhinum; Glinicum; Gonorrhoeal virus; Neisseria gonorrhoeae
Meningococcinum Meningococcinum; Neisseria meningitidis
Micrococcus tetragenus (Must be combined with Friedlander Bacillus of Pneumonia AND Mucotoxin) Peptostreptococcus tetradius
Mucotoxin Mucotoxin; Micrococcus catarrhalis
Mononucleosis Mononucleosis
Morbilinum Morbilinum
Mucor mucedo Mucor mucedo
Ourlianum Ourlianum
Pertussinum Pertussinum; Pertussin; Coqueluchin; Coqueluchinum
Pneumococcinum Pneumococcinum
Poliomyelitis Poliomyelitis
Proteus; Proteus inconstans; Proteus mirabilis; Proteus morgani; Proteus rettgeri; Proteus vulgaris Proteus; Proteus inconstans; Proteus mirabilis; Proteus morgani; Proteus rettgeri; Proteus vulgaris
Pseudomonas aeruginosa Pseudomonas aeruginosa; Pseudomonas
Psorinum Psorinum; Psoricum
Pyrogenium; Pyrogen Pyrogenium; Pyrogen
Salmonella typhi Salmonella typhi
Scarlatinum; Streptococcus pyogenes Scarlatinum; Streptococcus pyogenes
Sinusitisinum Sinusitisinum; Sinusitis nosode; Maxillary sinusitis nosode
Staphylococcinum; Staphylococcus; Staphylococcus aureus Staphylococcinum; Staphylococcus; Staphylococcus aureus; Staph;
Staphylotoxinum Staphylotoxinum
Streptococcinum; Streptococcus pyogenes Streptococcinum; Streptococcus pyogenes; Streptococcin; Pyogenic streptococcus
Syphilinum Syphilinum; Luesinum; Lueticum
Tetanotoxicum Tetanotoxicum
Tuberculinum; Tuberculin Tuberculinum; Tuberculin; Tuberculinum crudum; Old tuberculin
Tuberculinum bovinum; Bovine tuberculin Tuberculinum bovinum; Bovine tuberculin
Vaccinotoxinum; Smallpox Vaccinotoxinum; Smallpox; Vaccininum; variolae fluidum
Variolinum Variolinum

Source materials

Please refer to Appendix I.

Route(s) of administration

  • Oral
  • Sublingual
  • Nasal
  • Ophthalmic
  • Topical
  • Rectal

Dosage form(s)

Those pharmaceutical dosage forms suited to the routes of administration.

Use(s) or Purpose(s)

Statement(s) to the effect of

Nosodes preparation/remedy/medicine

Dose(s)

Subpopulation(s)

Adults (≥ 18 years) and adolescents (13-17 years)

Quantity(ies)

Note: The minimum homeopathic potency for each medicinal ingredient is listed in Appendix I.

Table 1 Dosage information for nosodes preparation.

Dosage form Maximum General Dosing Maximum Acute Dosing
Amount Frequency
Globules (small pellets, pilules) 1 whole unit dose (tube or container) Once per day 20 globules, 3 times per day
Granules (regular and large pellets) 5 granules 3 times per day Every 15-60 minutes (up to 12 times per day) or until improvement of symptoms. Then resume general dosing.
Tablets 4 tablets 4 times per day Every 15-60 minutes (up to 12 times per day) or until improvement of symptoms. Then resume general dosing.
Oral Drops 30 drops 3 times per day Every 15-60 minutes (up to 12 times per day) or until improvement of symptoms. Then resume general dosing
Liquid (Oral drinkable vials) 1 ampoule 3 times per day Up to three times per day.
Oral Solution (unit dose) 1 unit dose 3 times per day Give one unit dose upon onset of symptoms. Repeat two more times at 15-minute intervals. Repeat process up to 9 times per day if symptoms reappear.
Oral Syrup 1-2 tsp Every 4-6 hours Not applicable
Cream/Ointment Cover affected area As needed Not applicable
Nasal spray 2 sprays per nostril 5 times per day Not applicable
Suppositories 1 suppository 1-4 times per day Maximum 4 times per day

Method of preparation

The method of preparation must be one of the following:

  • HPUS Class I (Nosodes)
  • HAB Method 43 or 44 or 58a or 58b (Nosodes)
Directions of use

Take as directed by a health care practitioner.

Duration of use

Statement(s) to the effect of

No statement required.

Risk information

Statement(s) to the effect of

Caution(s) and warning(s)

  • If symptoms persist or worsen, consult a health care practitioner.
  • If you are pregnant or breastfeeding, consult a health care practitioner prior to use.

Contraindication(s)

This product is neither a vaccine nor an alternative to vaccination. This product has not been proven to prevent infection. Health Canada does not recommend its use in children and advises that your child receive all routine vaccinations.

Known adverse reaction(s)

No statement required.

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database NHPID and must meet the limitations outlined in the database.

Specifications

  • The finished product specifications must be established in accordance with the requirements described in the Natural and Non-Prescription Health Products Directorate Quality of Natural Health Products Guide.
  • The medicinal ingredient must comply with the requirements outlined in the NHPID .

References cited

Homeopathic Pharmacopeia of the United States (HPUS).

References reviewed

  • Encyclopedia of Homeopathic Pharmacopoeia (EHP).
  • Frans Vermeulen. Monera: Kingdom Bacteria and Viruses. Spectrum Materia Medica. Volume 1, Netherlands.
  • Frans Vermeulen. Fungi: Kingdom Fungi. Spectrum Materia Medica. Volume 2, Netherlands.
  • Hans-Heinrich Reckeweg. Materia Medica. Homoeopathia Antihomotoxica. Volume I. A Selective Pharmacology.
  • Robin Murphy. 1996. Lotus Materia Medica.
  • Rajkumar Mukherji. 2005. Julian's Materia Medica of Nosodes with Repertory. Treatise on Dynamised Micro-immnunotherapy.
  • William Boericke. Pocket Manual of Homoeopathic Materia Medica. 9th Ed.

Appendix I

Acceptable Potencies and Source Material(s) for Nosodes preparations

Proper name Common name Quantity Source Material
Anthracinum; Bacillus anthracis Anthracinum; Bacillus anthracis; Bacteridium anthracis 6X Sterilized lysate of liver of rabbit infected with Bacillus anthracis
Aspergillus niger Aspergillus niger 12CH Black mould
Bacille of Morgan; Morganella morgannii Bacille of Morgan; Morgan; Morganella morganii 12CH Bacteria isolated from faeces of man
Bacillinum pulmo Bacillinum pulmo 12CH Bacteria isolated from human lung tissue infected with Mycobacterium tuberculosis or Mycobacterium bovis
BCG BCG 12CH Dried living culture of Mycobacterium tuberculosis var. bovis
Botulinum Botulinum; Clostridium botulinum 12CH Bacteria isolated from contaminated food with with Clostridium botulinum
Calcarea renalis Calcarea renalis; Lapis renalis; Renal calculi 12CH Renal calculi
Candida albicans Candida albicans; Monilla albicans 12X Yeast cells from digestive system of man and animals
Candida parapsilosis Candida parapsilosis; Candida parakrusei; Monilla parapsilosis 12X Yeast cells from digestive system of man and animals
Carcinosin Carcinosin 12CH Cancer nosode from carcinoma
Chlamydia trachomatis Chlamydia trachomatis; Chlamydozoon trachomatis; Rickettsia trachomae; Rickettsia trachomatis 12CH Chlamydia trachomatis
Colibacillinum cum natrum muriaticum Colibacillinum cum natrum muriaticum; Escherichia coli in isotonic sodium chloride solution 8X Sterilized suspension of Escherichia coli in isotonic sodium chloride
Ophiocordyceps sinensis Ophiocordyceps sinensis; Cordyceps; Chinese Caterpillar Fungus; Dong Chong Xia Cao 12CH Ophiocordyceps sinensis (fungus)
Coxsackie Coxsackie 12CH Inactivated Coxsackie viruses of sub-groups A9 and B4
Diphtherinum Diphtherinum; Potentized diphtheritic microbe; Corynebacterium diphtheriae 12CH Diphtheria infected membrane
Eberthinum Eberthinum; Salmonella typhosa; Eberthella typhosa 12CH Stools from patients suffering from typhoid
Enterococcinum Enterococcinum; Mixed Enterococcus/Streptococcus stock 12CH Mixed Enterococcus/Streptococcus stock
Epstein barr Epstein Barr Virus; HHV-4 12CH Epstein-Barr Virus
Friedlander Bacillus of Pneumonia; Klebsiella pneumoniae Friedlander Bacillus of Pneumonia; Klebsiella pneumoniae; Bacillus mucosus capsulatus; Friedlander; Pneumobacillus 12CH Bacteria isolated from the bowel of man, soil, and/or water
Herpes simplex Herpes Simplex 12CH Herpes simplex secretion obtained by opening the vesicles
Herpes zoster Herpes Zoster 12CH Excretion obtained from shingles vesicles in various locations and at various stages
Hippozaeninum; Hippozaenin Hippozaeninum; Hippozaenin; Farcin; Farcine; Glanderin; Glanderine; Mallein 12CH Discharge from nose or skin lesions of untreated equine animals or humans with Pseudomonas mallei
Influenzinum; Influenza virus Influenzinum; Influenza virus; influenzae inactivum; Influenza; Inactivated influenza 8X Inactivated influenza virus type A and B individually or combined, from chicken embryo
Lyssin Lyssin; Hydrophobinum 12CH Saliva of rabid dog
Malandrinum Malandrinum 12CH Malanders (psoriasis of the bend of knees) of the horse
Malaria officinalis Malaria officinalis 12CH Dissolved gases from decomposed vegetable matter taken from marshes when malaria toxin is most active
Marmorek Marmorek 12CH Serum of tuberculosis induced in the horses
Medorrhinum Medorrhinum; Glinicum; Gonorrhoeal virus; Neisseria genethceae 12CH Purulent urethral secretions containing Neisseria gonorrhoeae
Meningococcinum Meningococcinum; Neisseria meningitidis 12CH Bacteria isolated from cerebral fluid of patients with meningitis
Micrococcus tetragenus (Must be combined with Friedlander Bacillus of Pneumonia AND Mucotoxin) Peptostreptococcus tetradius 12CH Lysate of culture of Mucotoxin, Friedlander Bacillus of Pneumonia and Micrococcus tetragenus
Mucotoxin Mucotoxin; Micrococcus catarrhalis 12CH Bacteria isolated from nasal discharge of patients suffering from pneumonia-like catarrh
Mononucleosis Mononucleosis 12CH Saliva from patients infected with Pfeiffer's disease (Mononucleosis) caused by the Epstein Barr Virus
Morbilinum Morbilinum 12CH Buccopharyngeal exudates from humans infected with measles
Mucor mucedo Mucor mucedo 12CH Whole fungus
Ourlianum Ourlianum 12CH Lysate from the saliva of patients suffering from mumps
Pertussinum Pertussinum; Pertussin; Coqueluchin; Coqueluchinum 12CH Sterilized lysate of the expectoration of untreated patients infected by Bordetella pertussin
Pneumococcinum Pneumococcinum 12CH Bacteria extracted from the saliva, nasal mucosa, mucosa of pharynx and conjunctiva of healthy person
Poliomyelitis Poliomyelitis 12CH Cerebrospinal fluid of poliomyelitis patients, obtained by lumbar puncture
Proteus; Proteus inconstans; Proteus mirabilis; Proteus morgani; Proteus rettgeri; Proteus vulgaris Proteus; Proteus inconstans; Proteus mirabilis; Proteus morgani; Proteus rettgeri; Proteus vulgaris 12CH Enterobacteria isolated from patients with gastroenteritis and urinary tract infections
Pseudomonas aeruginosa Pseudomonas aeruginosa; Pseudomonas 12CH Pseudomonas aeruginosa
Psorinum Psorinum; Psoricum 12CH Serous fluids from scabies lesions caused by itch mite Sarcoptes scabiei of untreated patients
Pyrogenium; Pyrogen Pyrogenium; Pyrogen 12X Lysate of ox flesh
Salmonella typhi Salmonella typhi 12CH Washings of a culture of Salmonella typhi
Scarlatinum; Streptococcus pyogenes Scarlatinum; Streptococcus pyogenes 12CH Whole bacteria sourced from man, animals, skin or air
Sinusitisinum Sinusitisinum; Sinusitis nosode; Maxillary sinusitis nosode 12X Mucous substances from inflamed sinus cavities of patients with acute sinusitis maxillaries
Staphylococcinum; Staphylococcus; Staphylococcus aureus Staphylococcinum; Staphylococcus; Staphylococcus aureus; Staph 12CH Sourced from mixed culture of Staphylococcus epidermidis, Staphylococcus haemolyticus, and Staphylococcus simulans
Staphylotoxinum Staphylotoxinum 12CH Anatoxin of staphylococcus
Streptococcinum; Streptococcus pyogenes Streptococcinum; Streptococcus pyogenes; Streptococcin; Pyogenic streptococcus 12CH From pure cultures of Streptococcus pyogenes free from antimicrobial agents
Syphilinum Syphilinum; Luesinum; Lueticum 12CH Extractions from syphlitic cankers of untreated patients
Tetanotoxicum Tetanotoxicum 12CH Tetanus toxin
Tuberculinum; Tuberculin Tuberculinum; Tuberculin; Tuberculinum crudum; Old tuberculin 12CH Solution from the concentrated soluble products of growth of the tubercle bacillus (Mycobacterium tuberculosis)
Tuberculinum bovinum; Bovine tuberculin Tuberculinum bovinum; Bovine tuberculin 12CH Solution from the concentrated soluble products of growth of the bovine tubercle bacillus (Mycobacterium bovis)
Vaccinotoxinum; Smallpox Vaccinotoxinum; Smallpox; Vaccininum; Variolae fluidum 12CH Living virus of vaccinia from strain of approved origin and grown on skin of vaccinated bovine calf
Variolinum Variolinum 12CH Lymph from small-pox pustule