Monograph: Bilberry - Oral
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NHPID name
Vaccinium myrtillus ( Germplasm Resources Information Network Taxonomy )Proper name(s)
Vaccinium myrtillus ( USDA 2008 )Common name(s)
- Bilberry ( McGuffin et al. 2000 )
- European blueberry ( Unavailable )
- Huckleberry ( Unavailable )
- Whortleberry ( Unavailable )
Source material
Fruit ( Blumenthal et al. 2000 )Route Of administration
OralDosage form(s)
Use(s) or purpose(s)
Statement(s) to the effect of:
- (Traditionally) used in Herbal Medicine as an astringent to help relieve diarrhoea.
- Source of/ Provides antioxidants.
- Used in Herbal Medicine to help slow the progression of disorders of the eye, such as diabetic and hypertensive retinopathy, and macular degeneration.
- Used in Herbal Medicine to help relieve symptoms related to non-complicated chronic venous insufficiency (CVI), such as sensation of swelling, heaviness and tingling of the legs.
Dose(s)
Adults:
Preparation:
1.8 - 75 Grams per day, dried fruit
Duration of use
No statement is requiredRisk information
Statement(s) to the effect of:
Caution(s) and Warning(s): Consult a health care practitioner/health care provider/health care professional/doctor/physician if symptoms persist or worsen. Contraindication(s): No statement is required Known Adverse Reaction(s): No statement is requiredNon-medicinal ingredients
Must be chosen from the current Natural health products ingredients database and must meet the limitations outlined in the database.Specifications
- The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of natural health products guide.
- The medicinal ingredient must comply with the requirements outlined in the Natural health products ingredient database (NHPID).
- The medicinal ingredient may comply with the specifications outlined in the following pharmacopoeial monographs: 'Dried Bilberry' in BP, 'Bilberry Fruit, Dried' and 'Fresh Bilberry Fruit Dry Extract, Refined and Standardised' in Ph. Eur., 'Powdered Bilberry Extract' in USP
References cited
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Barnes J, Anderson LA, Philipson JD. 2007. Herbal Medicines, 3rd edition. London (GB): Pharmaceutical Press.
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Blumenthal M, Goldberg A, Brinckmann J, editors. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
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Blumenthal M, Hall T, Goldberg A, Kunz T, Kinda K, editors. 2003. The ABC Clinical Guide to Herbs. Austin (TX): American Botanical Council
-
BP 2008: British Pharmacopoeia, Volume 1. Londron (UK): British Pharmacopoeia Commission. The Stationary Office.
-
ESCOP 2003: ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products, 2nd edition. Exeter (UK): European Scientific Cooperative on Phytotherapy and Thieme; 2003.
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European Pharmacopoeia, 6th edition. Strasbourg (France): Directorate for the Quality of Medicines and HealthCare of the Council of Europe (EDQM).; 2008
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Felter HW, Lloyd JU. 1983. King's American Dispensatory, Volume 2, 18th edition. Sandy (OR): Eclectic Medical Publications [Reprint of 1898 original].
-
Grieve M. 1971. A Modern Herbal, Volume 1. New York (NY): Dover Publications [Reprint of 1931 Harcourt, Brace & Company publication].
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McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. 2000. Herbs of Commerce, 2nd edition. Austin(TX): American Herbal Products Association.
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Mills S, Bone K. 2000. Principles and Practice of Phytotherapy. Toronto (ON): Churchill Livingstone.
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Mills S, Bone K. 2005. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone.
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Morazzoni P, Bombardelli E. 1996. Vaccinium myrtillus L. Fitoterapia 67(1):3-29.
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Upton R, editor. 2001. American Herbal Pharmacopoeia and Therapeutic Compendium: Bilberry Fruit Vaccinium mysrtillus L.: Standards of Analysis, Quality Control and Therapeutics. Santa Cruz (CA): American Herbal Pharmacopoeia
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USDA 2008: ARS, National Genetic Resources Program. Germplasm Resources Information Network (GRIN). National Germplasm Resources Laboratory, Beltsville (MD). [Accessed 2008-01-21]. Available at http://www.ars-grin.gov/cgi-bin/npgs/html/tax_search.pl
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USP 32 : United States Pharmacopeial Convention. 2009. United States Pharmacopeia and the National Formulary (USP 32 - NF 27). Rockville (MD): The United States Pharmacopeial Convention.
References reviewed
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Brinker F. 2001. Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications.
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Canter PH, Ernst E. 2004. Anthocyanosides of Vaccinium myritillus (bilberry) for night vision - a systematic review of placebo-controled trials. Survey of Opthalmology 49(1):38-50.
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Jang YP, Zhou J, Nakanishi K, Sparrow JR. 2005. Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. Photochemistry and Photobiology 81(3):529-536.
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Lee J, Lee HK, Kim Y, Hong YJ, Choe CM, You TW and Seong J. 2005. Purified high-dose anthocyanoside oligomer improves nocturnal vision and clinical symptoms in myopia subjects. British Journal of Nutrition 93:895-899.
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Levy Y, Glovinski Y. 1998. The effect of anthocyanosides on night vision. Eye 12:967-969.
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McGuffin M, Hobbs C, Upton R, Goldberg A, editors. 1997. American Herbal Products Association's Botanical Safety Handbook. Boca Raton (FL): CRC Press.
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Muth ER, Laurent JM and Purcell Jasper. 2000. The effect of bilberry nutritional supplementation on night vision acuity and contrast sensitivity. Alternative Medecine Review 5:164-73.
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Sparrow JR, Vollmer-Snarr HR, Zhou J, Jang PY, Jockusch. 2003. A2E-epoxides damage DNA in retinal pigment epithelial cells. Journal of Biological Chemistry 278(20):18207-18213.
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Steigwalt RD Jr, Gianni B, Paolo M, Bombardelli E, Burki C, Schönlau F. 2008. Effects of Mirtogenol® on ocular blood flow and intraocular hypertension in asymptomatic subjects. Molecular Vision 14:1288-1292.
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Zadok D, Levy Y, Glovinski Y. 1999. The effect of anthocyanosides in multiple oral dose on night vision. Eye 13:734-736.
Appendix 1: Examples of appropriate dosage preparations, frequencies of use and directions for use
ORAL:
Dried fruit:
- 20 - 60 g, per day (ESCOP 2003)
- 4 g, per day (Grieve 1971 [1931])
Decoction:
5 - 10 g dried fruit, 4-6 times per day (Blumenthal et al. 2000)
Directions for use:
Place crushed dried fruit in 150 ml of cold water. Bring to a boil for approximately 10 minutes. Strain while hot. Drink cold several times per day (Blumenthal et al. 2000)
Fluid extract:
- 2 - 4 g dried equivalent, 3 times per day (1:1, 2-4 ml) (Blumenthal et al. 2000)
- 3-6 g dried equivalent, per day (1:1, 3-6 ml) (Mills and Bone 2000)
- 1.8-7.4 g dried equivalent, per day (1:1, 1.8-7.4 ml (0.5-2 drachms)) (Grieve 1971 [1931])
Cold macerate:
5 - 10 g dried fruit, 4 - 6 times per day (Blumenthal et al. 2000)
Directions for use:
Soak crushed dried fruit in 150 ml cold water for 2 hours, allowing the fruit to swell. Drink cold several times per day (Blumenthal et al. 2000).