Monograph: St. John's Wort - Oral

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLA) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient. It is a referenced document to be used as a labelling standard. Note: (i) Text in parentheses is additional optional information which can be included on the PLA and product labels at the applicant's discretion. The solidus (/) indicates that the terms are synonyms or that the statements are synonymous. Either term or statement may be selected by the applicant. (ii) Claims for traditional use must include the term "Herbal Medicine".
Date: 2023-01-27

NHPID name

Hypericum perforatum ( Germplasm Resources Information Network Taxonomy )

Proper name(s)

Hypericum perforatum ( USDA 2008 )

Common name(s)

Source material

Herb top ( Bradley 2006 , Mills and Bone 2005 , Hoffmann 2003 , Blumenthal et al. 2000 , Felter and Lloyd 1983[1898] , Wren 1907 )

Route Of administration


Dosage form(s)

Use(s) or purpose(s)

Statement(s) to the effect of:




1 Day per day

See Appendix 1 for examples of appropriate dosage preparations and frequencies of use, according to cited references. The purpose of Appendix 1 is to provide guidance to industry.

Duration of use

Risk information

Statement(s) to the effect of:

Caution(s) and Warning(s): Contraindication(s): Do not use this product if you are taking anti-cancer, antidepressant [e.g. selective serotonin reuptake inhibitors (SSRI)], cardiovascular, contraceptive medications, blood thinners, anti-HIV agents and/or medications to suppress the immune system (immunosuppressive medications). Known Adverse Reaction(s): See Appendix 2 to find the references of the Caution and Contraindication statements about medication use.

Non-medicinal ingredients

Must be chosen from the current Natural health products ingredients database and must meet the limitations outlined in the database.


References cited

References reviewed

Appendix 1: Examples of appropriate dosage preparations, frequencies of use and directions for use


Dried aerial parts:

2-4 g, per day (Blumenthal et al. 2000; BHP 1983)


Fluid extract:

2-4 g dried equivalent, 3 times per day (1:1, 25% alcohol, 2-4 ml)(BHP 1983)


Dry hydroalcoholic extract/solild hydroalcoholic extract:


Appendix 2: Examples of classes of medications that can be affected by St. John's wort