Monograph: Glucosamine hydrochloride

Date: 2019-07-01

NHPID name

Glucosamine hydrochloride ( ChemIDplus Advanced )

Proper name(s)

2-Amino-2-deoxy-beta-D-glucopyranose hydrochloride ( NLM 2009 )

Common name(s)

• Glucosamine HCl ( Unavailable )
• Glucosamine hydrochloride ( Kralovec and Barrow 2008 , USP 2008 , Sweetman 2007 )

Source material

• Aspergillus flavus var. oryzae - Whole (Unavailable)
• Aspergillus melleus - Whole (Unavailable)
• Aspergillus niger var. awamori - Whole (Unavailable)
• Aspergillus niger - Whole (Unavailable)
• Crab - Exoskeleton (ITIS 2009, Kralovec and Barrow 2008)
• Krill - Exoskeleton (Unavailable)
• Lobster - Exoskeleton (ITIS 2009, Kralovec and Barrow 2008)
• Monascus pilosus - Whole (Unavailable)
• Monascus purpureus - Whole (Unavailable)
• Prawn - Exoskeleton (ITIS 2009, Kralovec and Barrow 2008)
• Rhizopus orysae - Whole (Unavailable)
• Shrimp - Exoskeleton (ITIS 2009, Kralovec and Barrow 2008)

The specific organisms used as source material(s) must be indicated in the Animal Tissue Form (ATF) because simply indicating "crustaceans" is insufficient.

Route Of administration

Oral

Dosage form(s)

• The acceptable pharmaceutical dosage forms include, but are not limited to capsules, chewables (e.g. gummies, tablets), liquids, powders, strips or tablets.
• This monograph is not intended to include foods or food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or purpose(s)

Statement(s) to the effect of:

Helps to maintain healthy cartilage/joint health.

Dose(s)

Adults:

Duration of use

Use for at least 1 month to see beneficial effects.  (Mehta et al. 2007, Usha and Naidu 2004, Houpt et al. 1999, Qiu et al. 1998)

Risk information

Statement(s) to the effect of:

Caution(s) and Warning(s):

• Consult a health care practitioner/health care provider/health care professional/doctor/ physician if symptoms worsen.  (Sivojelezova et al. 2007)
• Consult a health care practitioner/health care provider/health care professional/doctor/ physician prior to use if you are pregnant or breastfeeding.

Contraindication(s): No statement is required Known Adverse Reaction(s): No statement is required

Non-medicinal ingredients

Must be chosen from the current Natural health products ingredients database and must meet the limitations outlined in the database.

Specifications

• The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of natural health products guide.
• The medicinal ingredient must comply with the requirements outlined in the Natural health products ingredient database (NHPID).
• The medicinal ingredient may comply with the specifications outlined in the Glucosamine Hydrochloride and Glucosamine Tablets monographs published in the U.S. Pharmacopoeia.

References cited

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• Houpt JB, McMillan R, Wein C, Paget-Dellio SD. 1999. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. Journal of rheumatology 26(11):2423-2430
• ITIS 2009: Integrated Taxonomic Information System, Canadian Biodiversity Information Facility, Government of Canada [Accessed 2009-10-21]. Available from: http://www.cbif.gc.ca/pls/itisca/taxaget?p_ifx=cbif
• Kralovec A, Barrow CJ. 2008. Glucosamine Production and Health Benefits. Dans: Marine Nutraceuticals and Functional Foods. Colin Barrow and Fereidoon Shahidi, éditeurs, pp198-227. Boca Raton (FL): CRC Press, Taylor and Francis Group
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• NLM 2009: United States National Library of Medicine. ChemIDplus advanced [online]. Chemical name. RN: 000-00-0. Bethesda (MD): Specialized Information Services, United States National Library of Medicine, National Institutes of Health, United States Department of Health & Human Services. [Accessed 2009 May 19]. Available from: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?CHEM
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• Thie NM, Prasad NG, Major PW. 2001. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temperomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. The Journal of Rheumatology 28:1347-1355
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• Usha PR, Naidu MUR. 2004. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug Investigation 24(6):353-363.
• USP 32 : United States Pharmacopeial Convention. 2009. United States Pharmacopeia and the National Formulary (USP 32 - NF 27). Rockville (MD): The United States Pharmacopeial Convention.

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