Chemical Substance - Methylene chloride

NHPID name:
Methylene chloride

Reference:
CHEMID

Proper name(s):
Methylene chloride

Common name(s):

Category:
Approved Chemical Name
CAS registry number:
75-09-2



Additional details

Detail:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


Toxicity restriction

Upper limit:
6.0

Units:
Milligrams/24 hour

Detail:
Permitted daily exposure as residual solvent up to 6 mg/day, equivalent to a concentration limit of 6000 ppm when assuming a product mass of 10 g administered daily. This limit applies to all dosage forms and routes of administration.

Reference:
ICH


Roles

Non-medicinal

Purposes:
Solvent
Restrictions:

General

Detail:
Not permitted in aerosol products.

Reference:
CIH