Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on June 11, 2013.

ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent versions of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest versions of the e-PLA, namely versions 1.4.4 and 2.2.0. Version 1.4.4, known as the Cfgm ePLA, is dedicated to applications of type Compendial from generated monographs (Cfgm), which are used when attesting to a generated single ingredient monograph. Version 2.2.0 is for all application types except for Compendial from generated monographs. The forms are available for downloading from http://www.hc-sc.gc.ca/dhp-mps/prodnatur/applications/online-enligne/guidance-reference-eng.php.


New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
PVM/MA Decadiene Crosspolymer

Role:
Non-medicinal


NHPID Name:
L-Carnitine fumarate

Role:
Medicinal & Non-NHP


NHPID Name:
Glycyrrhiza Inflata Root Extract

Role:
Non-medicinal


NHPID Name:
Ulva Lactuca Powder

Role:
Non-medicinal


NHPID Name:
Vilanterol

Role:
Non-NHP


NHPID Name:
Olodaterol

Role:
Non-NHP


NHPID Name:
Pertuzumab

Role:
Non-NHP


NHPID Name:
Brentuximab vedotin

Role:
Non-NHP


NHPID Name:
Regorafenib

Role:
Non-NHP


NHPID Name:
Ulipristal Acetate

Role:
Non-NHP


NHPID Name:
Madecassoside

Role:
Non-medicinal


NHPID Name:
Mango juice

Role:
Non-medicinal


NHPID Name:
Apricot Juice

Role:
Non-medicinal


NHPID Name:
Spinacia oleracea (Spinach) extract

Role:
Non-medicinal


NHPID Name:
Parthenium integrifolium

Role:
Medicinal


NHPID Name:
Concentrated ammonia solution

Role:
Non-medicinal


NHPID Name:
Carbomer homopolymer

Role:
Non-medicinal


NHPID Name:
Acetogenins

Role:
No role


Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

No Changes.


Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

Old NHPID Name:
N-stearoyl-DL--sphinganine

New NHPID Name:
N-stearoyl-DL-erythro-sphinganine


Old NHPID Name:
Origanum minutiflorum herb oil

New NHPID Name:
Origanum minutiflorum herb essential oil


Old NHPID Name:
Oryzin

New NHPID Name:
Aspergillus alkaline protease


Old NHPID Name:
Foeniculum vulgare. subsp. vulgare var. dulce

New NHPID Name:
Foeniculum vulgare subsp. vulgare var. dulce


Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
D&C Red No. 28

New Common Name(s):
C.I. 45410


NHPID Name:
Lithol Rubin B

New Common Name(s):
C.I. 15850


NHPID Name:
Citral

Removed Proper Name(s):
Citral


NHPID Name:
Citral

Removed Common Name(s):
2,6-Octadienal, 3,7-dimethyl-; 3,7-Dimethyl-2,6-octadienal; 3,7-dimethylocta-2,6-dienal; 3,7-Dimethyl-trans-2,6-octadienal


NHPID Name:
Citral

New Proper Name(s):
3,7-Dimethyl-2,6-octadienal


NHPID Name:
Citral

New Common Name(s):
Citral


NHPID Name:
Citronellyl acetate

Removed Proper Name(s):
Citronellyl acetate


NHPID Name:
Citronellyl acetate

Removed Common Name(s):
(1)-3,7-Dimethyloct-6-enyl acetate; 3,7-Dimethyl-6-octen-1-ol acetate; 3,7-Dimethyl-6-octen-1-yl Acetate; 3,7-Dimethyl-6-octen-1-yl ethanoate; 3,7-dimethyloct-6-enyl acetate; 6-Octen-1-ol, 3,7-dimethyl-, acetate; 6-Octen-l-ol, 3,7-dimethyl-, acetate; Acetic acid, citronellyl ester


NHPID Name:
Citronellyl acetate

New Proper Name(s):
(1)-3,7-Dimethyloct-6-enyl acetate; 6-Octen-1-ol, 3,7-dimethyl-, acetate


NHPID Name:
Citronellyl acetate

New Common Name(s):
Citronellyl acetate


NHPID Name:
Epimedium sagittatum

New Common Name(s):
Sagittate epimedium


NHPID Name:
Fungal protease

New Common Name(s):
Aspergillus acid protease


NHPID Name:
Senegalia catechu

New Common Name(s):
Acacia catechu


NHPID Name:
Honey

Removed Common Name(s):
Feng mi


NHPID Name:
Leptospermum scoparium Honey

New Proper Name(s):
Leptospermum scoparium Honey


NHPID Name:
Leptospermum scoparium Honey

Removed Common Name(s):
Apis mellifera


NHPID Name:
Foeniculum vulgare subsp. vulgare var. dulce

New Proper Name(s):
Foeniculum vulgare subsp. vulgare var. dulce


NHPID Name:
Foeniculum vulgare subsp. vulgare var. dulce

Removed Common Name(s):
Foeniculum vulgare subsp. vulgare var. dulce


New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
L-Lactic acid

Old Role:
Non-medicinal

New Role:
Medicinal & Non-medicinal


NHPID Name:
Choline bitartrate

Old Role:
Medicinal

New Role:
Medicinal & Non-medicinal


NHPID Name:
alpha-Linolenic acid

Old Role:
Medicinal

New Role:
Medicinal & Non-medicinal


NHPID Name:
Wheatgrass

Old Role:
Non-medicinal

New Role:
Medicinal & Non-medicinal


Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Sage Essential Oil Dalmation

Restriction Reference removed:
FCC


NHPID Name:
Sage Essential Oil Dalmation

Non-medicinal Restriction(s) removed:
Flavour Enhancer


NHPID Name:
Honey

New Route(s) of Adminstration added:
Route Of Administration: Oral


NHPID Name:
Honey

New Route(s) of Adminstration added:
Route Of Administration: Topical


NHPID Name:
Acorus calamus

New Medicinal Restriction(s) added :
Toxic limits for beta-asarone: No more than (NMT) 10 mg/kg beta-asarone in dried rhizome of Acorus gramineus or NMT 115 mcg/day of beta-asarone in finished products.


NHPID Name:
Arthrospira maxima

New Medicinal Restriction(s) added :
As Spirulina species contain predominantly pseudo-vitamin B12, potencies of vitamin B12 are only acceptable if the supporting assays are based on the amount of bioactive, rather than bioavailable, vitamin B12.


NHPID Name:
Arthrospira platensis

Medicinal Restriction(s) Changed :
As Spirulina species contain predominantly pseudo-vitamin B12, potencies of vitamin B12 are only acceptable if the supporting assays are based on the amount of bioactive, rather than bioavailable, vitamin B12.


NHPID Name:
Borago officinalis

New Medicinal Restriction(s) added :
Leaves, stems and extracts of Borago officinalis must be tested to ensure absence of unsaturated pyrrolizidine alkaloids.


NHPID Name:
Equisetum arvense

New Medicinal Restriction(s) added :
Testing must be performed to ensure absence of thiaminase-like activity in Equisetum arvense.


NHPID Name:
Eupatorium perfoliatum

New Medicinal Restriction(s) added :
Testing must be performed to ensure the absence of pyrrolizidine alkaloids in Eupatorium purpureum.


NHPID Name:
Hydrangea arborescens

New Medicinal Restriction(s) added :
Testing must be performed to ensure absence of cyanogenic glycosides in Hydrangea arborescens.


NHPID Name:
Origanum minutiflorum

New Medicinal Restriction(s) added :
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


NHPID Name:
Origanum majorana

New Medicinal Restriction(s) added :
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


NHPID Name:
Origanum onites

New Medicinal Restriction(s) added :
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


NHPID Name:
Origanum syriacum

New Medicinal Restriction(s) added :
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


NHPID Name:
Origanum vulgare

New Medicinal Restriction(s) added :
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


NHPID Name:
Origanum vulgare subsp hirtum

New Medicinal Restriction(s) added :
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


NHPID Name:
Origanum vulgare subsp vulgare

New Medicinal Restriction(s) added :
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


NHPID Name:
Thymus serpyllum

New Medicinal Restriction(s) added :
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


NHPID Name:
Thymus vulgaris

New Medicinal Restriction(s) added :
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


NHPID Name:
Petasites hybridus

New Medicinal Restriction(s) added :
Testing must be performed to ensure the absence of pyrrolizidine alkaloids in Petasites hybridus


NHPID Name:
Piper methysticum

New Medicinal Restriction(s) added :
The amount of kavalactones in Piper methysticum should be provided for the Safety and Efficacy assessment of Product Licence Applications.


NHPID Name:
Senecio scandens

New Medicinal Restriction(s) added :
Testing must be performed to ensure the absence of pyrrolizidine alkaloids in Senecio scandens.


NHPID Name:
Symphytum officinale

Medicinal Restriction(s) removed:
Safety issues raised by the Canadian Poisonous Plant Information System need to be taken into consideration.


NHPID Name:
Symphytum officinale

Medicinal Restriction(s) removed:
Testing must be performed to ensure the absence of pyrrolizidine alkaloids (e.g. Echimidine) in Symphytum officinale


NHPID Name:
Tussilago farfara

New Medicinal Restriction(s) added :
Testing must be performed to ensure the absence of pyrrolizidine alkaloids in Tussilago farfara


NHPID Name:
Viscum album

New Medicinal Restriction(s) added :
Testing must be performed on Viscum album to ensure a maximum level of viscotoxin in the finished product of 17 µg/mL (or µg/g


NHPID Name:
Glycerol

Route(s) of Adminstration removed:
Rectal


NHPID Name:
Glycerol

New Route(s) of Adminstration added:
Oral


NHPID Name:
Shark cartilage

New Medicinal Restriction(s) added :
Testing must be performed to ensure absence of beta-N-Methylamino-L-alanine (BMAA) in shark cartilage.


NHPID Name:
Origanum majorana leaf oil; Oleoresin Marjoram Sweet; Origanum vulgare leaf extract; Origanum vulgare leaf oil; Sweet marjoram essential oil; Thymus Vulgaris (Thyme) Leaf Extract; Origanum minutiflorum herb essential oil

New Non-medicinal Restriction(s) added:
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


NHPID Name:
European Oregano Essential Oil; Greek Oregano Essential Oil; Oleoresin Marjoram Sweet; Oregano Oil; Origanum Oil Spanish; Sweet marjoram essential oil; Turkish Oregano Essential Oil

New Medicinal Restriction(s) added :
The quantity or concentration of carvacrol in all applicable essential oils or extracts must be declared.


Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
PEG-6 Caprylic/Capric Glycerides

New NMI Purpose(s):
Emulsifying Agent; Surfactant


NHPID Name:
Ammonio methacrylate copolymer dispersion

New Additional Details added :
Ammonio methacrylate copolymer dispersion is an aqueous dispersion of Ammonio methacrylate copolymer Type A or B in water (USP).


NHPID Name:
Sage Essential Oil Dalmation

New NMI Purpose(s):
Fragrance Ingredient


NHPID Name:
Sage Essential Oil Dalmation

Additional Details removed:
Flavouring agent only


NHPID Name:
Vilanterol

New Source Ingredient(s) added:
Vilanterol trifenatate


NHPID Name:
Olodaterol

New Source Ingredient(s) added:
Olodaterol hydrochloride


NHPID Name:
Terpineol

New NMI Purpose(s):
Fragrance Ingredient


NHPID Name:
Carboxypolymethylene

New CAS Registry Number(s) added:
9003-01-04


NHPID Name:
Bioflavonoids

New Source Material(s) added:
Scutellaria baicalensis


NHPID Name:
Bioflavonoids

New Source Material(s) added:
Senegalia catechu


NHPID Name:
(+)-Catechin

New Source Material(s) added:
Senegalia catechu


NHPID Name:
Sodium bicarbonate

New Additional Details added :
Sodium is an electrolyte, not a nutrient. As a medicinal ingredient sodium does not contribute to the maintenance of good health since there is likely to be excess sodium from the diet, not a deficiency. The safety and efficacy of the sodium bicarbonate as a source of sodium must be assessed under the recommended conditions of use.


NHPID Name:
Wheatgrass

New Method(s) of Preparation added:
Fresh


NHPID Name:
alpha-Hydroxyisocaproic acid

New Source Ingredient(s) added:
alpha-Hydroxyisocaproic acid


NHPID Name:
Glycyrrhiza glabra (Root)

New Sub-ingredient(s) added:
Licochalcone A


NHPID Name:
Glycyrrhiza inflata (Root)

New Sub-ingredient(s) added:
Licochalcone A


Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

Modification:
Posting for consultaion of:
  • Chitosan
  • Phaseolus vulgaris (Kidney bean)
  • L-carnitine
  • Oat beta glucan
  • Inulin
  • Cayenne


Modification:
Final posting of the folllowing monographs: melatonin- Oral and sublingual


AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.


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