WILLOW BARK

Help on accessing alternative formats, such as Portable Document Format (PDF), Microsoft Word and PowerPoint (PPT) files, can be obtained in the alternate format help section.

This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.

Notes

Date

October 28, 2022

Proper name(s), common name(s), Source information

Table 1: Proper name(s), common name(s), Source information
Proper name(s) Common name(s) Source information
Source material(s) Part(s) Preparation(s)

Willow Bark

Willow Bark

  • Salix alba
  • Salix daphnoides
  • Salix purpurea
  • Salix x fragilis

Young branch bark

Dry

References: Proper name: Blumenthal et al. 2000, Bradley 1992; Common name: Blumenthal et al. 2000, Bradley 1992; Source information: USDA 2019, Wichtl 2004, ESCOP 2003, Blumenthal et al. 2000.

Route of administration

Oral

Dosage form(s)

Use(s) or Purpose(s)

The following combined use(s) or purpose(s) is/are also acceptable:

(Traditionally) used in Herbal Medicine to relieve minor joint pain (due to osteoarthritis), headache pain and for short-term relief of low back pain (EMA 2017; ESCOP 2003).

Note
Claims for traditional use must include the term "Herbal Medicine", "Traditional Chinese Medicine", or "Ayurveda".

Dose(s)

Subpopulation(s)

Adults 18 years and older

Quantity(ies)

Methods of preparation: Dry, Powdered, Non-Standardized Extracts (Dry extract, Tincture, Fluid extract, Decoction, Infusion)

3- 9 grams of dried young branch bark per day in divided doses: Not to exceed 3 grams per single dose (EMA 2017; ESCOP 2003; Barnes et al. 2002; Blumenthal et al. 2000)

Methods of preparation: Standardized extracts (Dry extract, Tincture, Fluid extract, Decoction, Infusion)

Extract providing up to 15% total salicin equivalent to 45 - 240 milligrams of total salicin per day in divided doses: Not to exceed 120 milligrams of salicin per single dose (EMA 2017; WHO 2009; Wichtl 2004; ESCOP 2003; Barnes et al. 2002; Blumenthal et al. 2000)

Direction(s) for use

No statement required

Duration(s) of use

Consult a health care practitioner/health care provider/health care professional/doctor/physician for prolonged use (EMA 2017; Beer and Wegener 2008; Biegert et al. 2004; Chrubasik 2000).

Risk information


Caution(s) and warning(s)

Contraindication(s)

Known adverse reaction(s)

Some people may experience gastrointestinal discomfort/disturbances (EMA 2017; Brinker 2010; Wichtl 2004; ESCOP 2003; Barnes et al. 2002; Blumenthal et al. 2000)

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage conditions

Must be established in accordance with the requirements described in the Natural Health Products Regulations (NHPR).

Specifications

References cited