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Drugs and Health Products

Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on November 25, 2022.

ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the web-based Product Licence Application (web PLA) form. All new product licence application submissions must use the web PLA form.


New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Cassia Hydroxypropyltrimonium Chloride

Role:
Non-Medicinal


NHPID Name:
Chondroitin Sulfate Oligosaccharides

Role:
Medicinal


NHPID Name:
Propanediol caprylate

Role:
No role


NHPID Name:
Carya Illinoinensis (Pecan) Shell Extract

Role:
Non-medicinal


NHPID Name:
Hydrotalcite

Role:
Medicinal


NHPID Name:
Fish Cartilage Hydrolysate

Role:
Medicinal


NHPID Name:
Silica Caprylyl Silylate

Role:
Non-medicinal


Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

No Changes.


Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

Old NHPID Name:
Dibenzoyl thiamine hydrochloride

New NHPID Name:
Bentiamine hydrochloride


Old NHPID Name:
All-trans retinol

New NHPID Name:
all-trans-Retinol


Old NHPID Name:
Vitamin A acetate

New NHPID Name:
all-trans-Retinyl acetate


Old NHPID Name:
Vitamin A palmitate

New NHPID Name:
all-trans-Retinyl palmitate


Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Bentiamine hydrochloride

Removed Proper Name(s):
Dibenzoyl thiamine hydrochloride


NHPID Name:
Bentiamine hydrochloride

New Proper Name(s):
O,S-Dibenzoyl thiamine hydrochloride


NHPID Name:
Bentiamine hydrochloride

New Common Name(s):
Bentiamine hydrochloride


NHPID Name:
Sulbutiamine

Removed Proper Name(s):
Sulbutiamine


NHPID Name:
Sulbutiamine

New Proper Name(s):
Thiamine disulfide O,O-diisobutyrate


NHPID Name:
Sulbutiamine

Removed Common Name(s):
Thiamine disulfide O,O-diisobutyrate


NHPID Name:
Sulbutiamine

New Common Name(s):
Sulbutiamine


NHPID Name:
Thiamine Disulfide

New Common Name(s):
Thiamine disulfide


NHPID Name:
Vitamin A

Removed Common Name(s):
Retinol


NHPID Name:
all-trans-Retinol

Removed Proper Name(s):
All-trans retinol


NHPID Name:
all-trans-Retinol

New Proper Name(s):
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol


NHPID Name:
all-trans-Retinol

Removed Common Name(s):
All-trans retinol


NHPID Name:
all-trans-Retinol

New Common Name(s):
Retinol


NHPID Name:
all-trans-Retinyl palmitate

Removed Common Name(s):
All-trans retinyl palmitate


NHPID Name:
Conductase

Removed Proper Name(s):
Pyridoxine alpha-Ketoglutarate


NHPID Name:
Conductase

New Common Name(s):
Pyridoxine alpha-ketoglutarate


NHPID Name:
Pyridoxamine

Removed Proper Name(s):
Pyridoxamine


NHPID Name:
Pyridoxamine

New Proper Name(s):
4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol


NHPID Name:
Pyridoxamine 5'-phosphate

Removed Proper Name(s):
Pyridoxamine 5'-phosphate


NHPID Name:
Pyridoxamine 5'-phosphate

New Proper Name(s):
4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol 3-(dihydrogen phosphate)


NHPID Name:
Pyridoxine 5'-phosphate

Removed Proper Name(s):
Pyridoxine 5'-phosphate


NHPID Name:
Pyridoxine 5'-phosphate

New Proper Name(s):
5-Hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate


NHPID Name:
Cyanocobalamin

Removed Proper Name(s):
Cyanocobalamin


NHPID Name:
Cyanocobalamin

New Proper Name(s):
Cobinamide cyanide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole inner salt


NHPID Name:
Vitamin C

Removed Common Name(s):
Ascorbic acid


NHPID Name:
Potassium iodate

Removed Proper Name(s):
Potassium iodate


NHPID Name:
Potassium iodate

New Proper Name(s):
Iodic acid (HIO3) potassium salt (1:1)


NHPID Name:
D-Pantothenic acid

Removed Common Name(s):
D-Pantothenic acid


NHPID Name:
Calcium D-pantothenate

Removed Common Name(s):
Calcium d-pantothenate; Calcium pantothenate; Pantothenic acid calcium salt


NHPID Name:
Dexpanthenol

New Proper Name(s):
(2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide


NHPID Name:
Sodium D-pantothenate

Removed Common Name(s):
Pantothenic acid, sodium salt; Sodium pantothenate


New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
Vitamin C

Old Role:
Non-Medicinal

New Role:
No Role


NHPID Name:
Ascorbic acid

Old Role:
No Role

New Role:
Non-Medicinal


NHPID Name:
Sulbutiamine

Old Role:
Medicinal

New Role:
No Role


NHPID Name:
Thiamine diphosphate

Old Role:
Medicinal

New Role:
No Role


NHPID Name:
Vitamin A

Old Role:
Non-Medicinal

New Role:
No Role


NHPID Name:
all-trans-Retinol

Old Role:
No role

New Role:
Non-medicinal


NHPID Name:
Vitamin A acetate

Old Role:
Medicinal

New Role:
No Role


NHPID Name:
all-trans-Retinyl palmitate

Old Role:
Medicinal

New Role:
No Role


NHPID Name:
Pyridoxal

Old Role:
Medicinal

New Role:
No Role


NHPID Name:
Pyridoxal 5'-phosphate

Old Role:
Medicinal

New Role:
No Role


NHPID Name:
Vitamin B12

Old Role:
Non-Medicinal

New Role:
No Role


NHPID Name:
Vitamin B12

Old Role:
No Role

New Role:
Non-NHP


NHPID Name:
Cyanocobalamin

Old Role:
No Role

New Role:
Non-medicinal


NHPID Name:
Methylcobalamin

Old Role:
Medicinal

New Role:
No role


NHPID Name:
Ascorbic acid 2-O-glucoside

Old Role:
Medicinal

New Role:
No Role


NHPID Name:
Manganese (II) ascorbate

Old Role:
Medicinal

New Role:
No Role


NHPID Name:
Zinc ascorbate

Old Role:
Medicinal

New Role:
No Role


NHPID Name:
Potassium iodate

Old Role:
No role

New Role:
Non-medicinal


NHPID Name:
Calcium DL-pantothenate

Old Role:
Non-medicinal

New Role:
No role


NHPID Name:
Dexpanthenol

Old Role:
Medicinal

New Role:
No role


NHPID Name:
D-Pantethine

Old Role:
Medicinal

New Role:
No role


Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Ascorbic acid 2-O-glucoside

New Route(s) of Adminstration added:
Topical


NHPID Name:
Ascorbic acid 2-O-glucoside

New Non-medicinal Restriction(s) added:
For topical use only, up to 5%.


NHPID Name:
Ascorbic acid

New Route(s) of Adminstration added:
Topical


NHPID Name:
Ascorbic acid

New Non-medicinal Restriction(s) added:
Allowed Purposes: Preservative Antioxidant; Skin-Conditioning Agent


NHPID Name:
Ascorbic acid

New Non-medicinal Restriction(s) added:
Detail:Up to 10%.


NHPID Name:
Ascorbic acid

New Route(s) of Adminstration added:
Oral


NHPID Name:
Ascorbic acid

New Non-medicinal Restriction(s) added:
Allowed Purposes:Preservative Antioxidant


NHPID Name:
Ascorbic acid

New Non-medicinal Restriction(s) added:
Detail:Up to 0.1%.


NHPID Name:
Ascorbic acid

New Non-medicinal Restriction(s) added:
Allowed Purposes:Flavour Enhancer


NHPID Name:
Ascorbic acid

New Non-medicinal Restriction(s) added:
Detail:Up to 8.87 ppm.


NHPID Name:
Hydrolyzed elastin

New Route(s) of Adminstration added:
Topical


NHPID Name:
Hydrolyzed elastin

New Non-medicinal Restriction(s) added:
Detail:For topical use only, up to 5%.


NHPID Name:
Ginkgo biloba

New Non-medicinal Restriction(s) added:
Detail:In order to reduce toxicity, the following must be processed before use as a Traditional Chinese Medicine ingredient: Ginkgo biloba seeds must be either dry-fried or baked at a medium temperature until they turn deep yellow in order to break down ginkgotoxin.


NHPID Name:
Ascorbyl methylsilanol pectinate

New Non-medicinal Restriction(s) added:
Detail:For topical use only.


NHPID Name:
Thiamine diphosphate

New Route(s) of Adminstration added:
Topical


NHPID Name:
Thiamine diphosphate

New Non-medicinal Restriction(s) added:
For topical use only.


NHPID Name:
Thiamine hydrochloride

New Non-medicinal Restriction(s) added:
For topical use only.


NHPID Name:
all-trans-Retinyl palmitate

Route(s) of Adminstration removed:
Oral


NHPID Name:
Pyridoxine

New Route(s) of Adminstration added:
Topical


NHPID Name:
Pyridoxine hydrochloride

New Non-medicinal Restriction(s) added:
Detail:For topical use only.


NHPID Name:
Cyanocobalamin

New Route(s) of Adminstration added:
Topical


NHPID Name:
Potassium iodate

New Route(s) of Adminstration added:
Topical


NHPID Name:
Dexpanthenol

New Non-medicinal Restriction(s) added:
For topical use only, up to 6%.


NHPID Name:
D-Pantethine

New Non-medicinal Restriction(s) added:
For topical use only.


NHPID Name:
Riboflavin

New Route(s) of Adminstration added:
Topical


NHPID Name:
Riboflavin 5'-phosphate sodium

Non-medicinal Restriction(s) changed:
Allowed Purposes: Colour Additive, Skin-Conditioning Agent


NHPID Name:
PEG-15/Lauryl Dimethicone Crosspolymer

New Non-medicinal Restriction(s) added:
Skin-Conditioning Agent


Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Ginkgo biloba

New Additional Details added :
Ginkgolic acids: Testing must be performed to ensure that the finished product meets the toxicity restrictions for Ginkgolic acids of not more than 5 ppm [USP 43-NF38; Ph.eur. 11th edition 2022 (11.1); Boateng and Yang 2022; Boateng 2022].


NHPID Name:
Ginkgo biloba-Phosphatidylcholine complex

New Additional Details added :
Ginkgolic acids: Testing must be performed to ensure that the finished product meets the toxicity restrictions for Ginkgolic acids of not more than 5 ppm [USP 43-NF38; Ph.eur. 11th edition 2022 (11.1); Boateng and Yang 2022; Boateng 2022].


NHPID Name:
Folium Ginkgo

Additional Details changed:
Ginkgolic acids: Testing must be performed to ensure that the finished product meets the toxicity restrictions for Ginkgolic acids of not more than 5 ppm [USP 43-NF38; Ph.eur. 11th edition 2022 (11.1); Boateng and Yang 2022; Boateng 2022].


NHPID Name:
Semen Ginkgo

Additional Details changed:
Ginkgolic acids: Testing must be performed to ensure that the finished product meets the toxicity restrictions for Ginkgolic acids of not more than 5 ppm [USP 43-NF38; Ph.eur. 11th edition 2022 (11.1); Boateng and Yang 2022; Boateng 2022].


NHPID Name:
Harpagoside

New Source Material(s) added:
Harpagophytum procumbens ( Parts: Secondary root tuber )


NHPID Name:
Harpagophytum procumbens

Modification:
Added Source Material Constituent(s): Secondary root tuber


NHPID Name:
Thiamine

New Source Ingredient(s) added:
Thiamine disulfide


NHPID Name:
Sulbutiamine

Source Ingredient(s) removed:
Thiamine Disulfide


NHPID Name:
Thiamine Disulfide

Sub-ingredient(s) removed:
Sulbutiamine


NHPID Name:
Thiamine Disulfide

New Sub-ingredient(s) added:
Thiamine


NHPID Name:
all-trans-Retinol

New Additional Details added :
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in topical natural health products, unless additional evidence for safety is submitted.


NHPID Name:
Vitamin B12

Additional Details removed:
Vitamin B12 with Intrinsic Factor Concentrate is a non-NHP (as a combination) as it is listed in the Prescription Drug List (PDL).


NHPID Name:
Carbon dioxide

Removed NMI purpose(s):
PH Adjuster


NHPID Name:
Carbon dioxide

New NMI Purpose(s):
Carbonating Agent


NHPID Name:
Octanoic acid

New Sub-ingredient(s) added:
Propanediol caprylate


NHPID Name:
Hydrolyzed collagen type II

Source Material(s) removed:
Leucoraja naevus (Parts: Cartilage) ; Raja brachyura (Parts: Cartilage) ; Raja clavata (Parts: Cartilage)


Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

Modification:
Secondary Sunscreen Monograph


Modification:
Primary Sunscreen Monograph


Modification:
Stem bromelain


Modification:
Fruit bromelain


AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

Modification:
Hydrosol: Water charged, by distillation, with volatile plant principles.


Modification:
Capsule, liquid filled: solid preparation with hard or soft shell, of variable shape and capacity, usually containing a single dose of active ingredients for oral administration. The active ingredients are dissolved or suspended in a liquid vehicle.


Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.

RemIng

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