RESVERATROL

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.

Notes

Date

August 28, 2018

Proper name(s), Common name(s), Source material(s)

Table 1. Proper name(s), Common name(s), Source material(s)
Proper name(s) Common name(s) Source material(s)
Proper name(s) Part(s) Common name(s) Preparation(s)
  • (E)-5-(p-Hydroxystyryl) resorcinol
  • 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
  • trans-3,4',5-Trihydroxystilbene
  • trans-Resveratrol

Resveratrol

Reynoutria japonica

Root

N/A

N/A

Vitis vinifera

Fruit

N/A

N/A

N/A

N/A

Resveratrol

Synthetic

References: Proper names: PubChem 2018; O'Neil 2013, Common name: O'Neil 2013; Source materials: USDA 2018, O'Neil 2013, La Porte et al. 2010, Bertelli and Das 2009, Dani et al. 2007.

Route of Administration

Oral

Dosage Form(s)

This monograph excludes foods or food-like dosage forms as indicated in the Compendium of Monographs Guidance Document.

Acceptable dosage forms for the age category listed in this monograph and specified route of administration are indicated in the Compendium of Monographs Guidance Document.

Use(s) or Purpose(s)

(Provides) An antioxidant (Ghanim et al. 2010; Rocha et al. 2009).

Dose(s)

Subpopulation(s)

Adults 18 years and older

Quantity(ies)

Not to exceed 1 gram of resveratrol, per day (Cottart et al. 2013; Brown et al. 2010; Gaby 2006).

Direction(s) for use

No statement required.

Duration(s) of Use

Products providing more than 250 mg of resveratrol, per day

Consult a health care practitioner/health care provider/health care professional/doctor/physician for prolonged use (Vang et al. 2010).

Risk Information

Caution(s) and warning(s)

Contraindication(s)

No statement required.

Known adverse reaction(s)

Products providing 500 mg or more of resveratrol, per day

May cause nausea, abdominal pain, and/or diarrhea (Brown et al. 2010; Chow et al. 2010).

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage conditions

No statement required.

Specifications

References cited

References reviewed