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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.



December 30, 2022

Proper name(s), Common name(s), Source information

Table 1. Proper name(s), Common name(s), Source information
Proper name(s) Common name(s) Source information
Source ingredient(s) Preparation(s)
  • Dimethyl sulfone
  • Methylsulfonylmethane
  • Sulfonylbismethane
  • Methylsulfonylmethane
  • MSM

Dimethyl sulfone


References: Proper names: NLM 2009, O'Neil et al. 2006; Common names: NLM 2009, O'Neil et al. 2006; Source information: Zajac et al. 2003, Gennaro 2000.

Route of Administration


Dosage Form(s)

This monograph excludes foods or food-like dosage forms as indicated in the Compendium of Monographs Guidance Document.

Acceptable dosage forms for oral use are indicated in the dosage form drop-down list of the web-based Product Licence Application form for Compendial applications

Use(s) or Purpose(s)

Helps to relieve (joint) pain associated with osteoarthritis (of the knee) (Kim et al. 2005; Usha and Naidu 2004).



Adults 18 years and older


1,500 - 6,000 milligrams of MSM, per day; Not to exceed 2,000 milligrams per single dose (Kim et al. 2005; Usha and Naidu 2004)

Direction(s) for use

Products providing 1,500 mg or more of MSM, per day

Duration(s) of Use

Use for at least 1 month to see beneficial effects (Kim et al. 2005; Usha and Naidu 2004).

Risk Information

Caution(s) and warning(s)


No statement required.

Known adverse reaction(s)

Some people may experience gastrointestinal discomfort/disturbances (Kim et al. 2005).

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage conditions

Must be established in accordance with the requirements described in the Natural Health Products Regulations (NHPR).


References Cited

References Reviewed