GLOBE ARTICHOKE - CYNARA CARDUNCULUS
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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.
Notes
- Text in parentheses is additional optional information which can be included on the PLA and product label at the applicant's discretion.
- The solidus (/) indicates that the terms and/or statements are synonymous. Either term or statement may be selected by the applicant.
Date
December 18, 2018
Proper name(s), Common name(s), Source material(s)
Proper name(s) | Common name(s) | Source material(s) | ||
---|---|---|---|---|
Proper name(s) | Part(s) | Preparation | ||
Cynara cardunculus |
|
Cynara cardunculus |
Leaf |
Dried |
References: Proper name: USDA 2018; Common names: McGuffin et al. 2000; Source material: Bradley 2006, ESCOP 2003, Blumenthal et al. 2000.
Route of Administration
Oral
Dosage Form(s)
This monograph excludes foods or food-like dosage forms as indicated in the Compendium of Monographs Guidance Document.
Acceptable dosage forms for the age category listed in this monograph and specified route of administration are indicated in the Compendium of Monographs Guidance Document.
Use(s) or Purpose(s)
- Used in Herbal Medicine to help relieve digestive upset, such as indigestion (Bradley 2006; ESCOP 2003; Blumenthal et al. 2000).
- Used in Herbal Medicine to help increase bile flow (choleretic) (Bradley 2006; Mills and Bone 2005; ESCOP 2003; Hoffmann 2003; Blumenthal et al. 2000).
The following combined use(s) or purpose(s) is/are also acceptable:
Used in Herbal Medicine to help relieve digestive upset, such as indigestion and help increase bile flow (choleretic) (Bradley 2006; Mills and Bone 2005; ESCOP 2003; Hoffmann 2003; Blumenthal et al. 2000).
Dose(s)
Subpopulation(s)
Adults 18 years and older
Quantity(ies)
Methods of preparation: Dry, Powder, Non-Standardised Extracts (Dry extract, Tincture, Fluid extract, Decoction, Infusion)
1.5 - 10 grams of dried leaf, per day (Bradley 2006; Mills and Bone 2005; ESCOP 2003; Blumenthal et al. 2000).
Direction(s) for use
No statement required.
Duration(s) of Use
No statement required.
Risk Information
Caution(s) and warning(s)
- Consult a health care practitioner/health care provider/health care professional/doctor/ physician if symptoms persist or worsen.
- Consult a health care practitioner/health care provider/health care professional/doctor/ physician prior to use if you are pregnant or have gall stones (Barnes et al. 2007; Mills and Bone 2005; ESCOP 2003; Brinker 2010; Blumenthal et al. 2000).
Contraindication(s)
Do not use this product if you have a bile duct obstruction (Brinker 2010; Bradley 2006; ESCOP 2003; Blumenthal et al. 2000).
Known adverse reaction(s)
Stop use if hypersensitivity/allergy occurs (Brinker 2010; Bradley 2006; ESCOP 2003; Blumenthal et al. 2000).
Non-medicinal ingredients
Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.
Storage conditions
No statement required.
Specifications
- The finished product specifications must be established in accordance with the requirements described in the Natural and Non-prescription Health Products Directorate (NNHPD) Quality of Natural Health Products Guide.
- The medicinal ingredient must comply with the requirements outlined in the NHPID.
References Cited
- Barnes J, Anderson LA, Philipson JD. Herbal Medicines, 3rd edition. London (UK): The Pharmaceutical Press; 2007.
- Blumenthal M, Goldberg A, Brinkmann J, editors. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
- Bradley PR, editor. British Herbal Compendium: A Handbook of Scientific Information on Widely Used Plant Drugs, Volume 2. Bournemouth (UK): British Herbal Medicine Association; 2006.
- Brinker F. Herb Contraindications and Drug Interactions, 4th edition. Sandy (OR): Eclectic Medical Publications; 2010.
- ESCOP 2003: ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products, 2nd edition. Exeter (UK): European Scientific Cooperative on Phytotherapy and Thieme; 2003.
- Hoffmann D. Medical Herbalism. Rochester (VT): Healing Arts Press; 2003.
- McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. Herbs of Commerce, 2nd edition. Silver Spring (MD): American Herbal Products Association; 2000.
- Mills S, Bone K. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone; 2005.
- USDA 2018: ARS, National Genetic Resources Program. Germplasm Resources Information Network (GRIN). Cynara cardunculus L. National Germplasm Resources Laboratory, Beltsville (MD). [Accessed 2018 September 27]. Available from: https://npgsweb.ars-grin.gov/gringlobal/taxonomydetail.aspx?id=12839
References Reviewed
- Sinayoko L, Mennecier D, El Jahir Y, Corberand D, Harnois F, Thiolet C, Farret O. [Acute hepatic injury secondary to ingestion of artichoke extracts (Hepanephrol).] Atteinte hépatique aiguë secondaire à la prise d'extraits d'artichaut (Hépanéphrol®). Gastroentérologie clinique et biologique 2007; 31(11):1039-1040 (in French).