GINKGO - GINKGO BILOBA

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Monograph: GINKGO <em>GINKGO BILOBA</em> (English) (PDF Version - 36 K)

This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLA) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.

Notes

Date

January 27, 2023

Proper name(s), Common name(s), Source information

Table 1. Proper name(s), Common name(s), Source information
Proper name(s) Common name(s) Source information
Source material(s) Part(s)
Ginkgo biloba
  • Ginkgo
  • Ginkgo biloba
  • Maidenhair tree
  • Baiguo
  • Icho
 Ginkgo biloba Leaf

References: Proper name: USDA 2018; Common names: USDA 2018, McGuffin et al. 2000, WHO 1999, Source information: Birks and Evans 2007.

Route(s) of administration

Oral

Dosage form(s)

This monograph excludes foods or food-like dosage forms as indicated in the Compendium of Monographs Guidance Document.

Acceptable dosage forms for oral use are indicated in the dosage form drop-down list of the web-based Product Licence Application form for Compendial applications.

Use(s) or Purpose(s)

The following combined use(s) or purpose(s) is/are also acceptable:

Dose(s)

Subpopulation(s)

Adults 18 years and older

Quantity(ies)

Methods of Preparation: Standardized Extracts (Dry extract)

80 - 240 milligrams of extract, per day (50:1; quantity crude equivalent 4 - 12 grams of dried leaves), standardized to 22-27% flavonoid glycosides and 5-7% terpene lactones; and providing at least 80 milligrams of extract per single dose (Crew et al. 2005; Cieza et al. 2003; Santos et al. 2003; Mix and Crews 2002; Blumenthal et al. 2000; Kennedy et al. 2000; Pittler and Ernst 2000; WHO 1999).

Direction(s) for use

No statement required.

Duration of use

Products providing 80 mg to less than 120 mg of extract (4 g to less than 6 g dried leaves), per day

Consult a health care practitioner/health care provider/health care professional/doctor/physician for use beyond 8 months (Santos et al. 2003; Le Bars et al. 1997; Grassel 1992).

Products providing 120 mg to 180 mg of extract (6 g to 9 g dried leaves), per day

Consult a health care practitioner/health care provider/health care professional/doctor/physician for use beyond 6 weeks (Elsabagh et al. 2005; Mix and Crews 2002; Mix and Crews 2000).

Products providing more than 180 mg to 240 mg of extract (more than 9 g to 12 g dried leaves), per day

Consult a health care practitioner/health care provider/health care professional/doctor/physician for use beyond 4 weeks (Cieza et al. 2003).

Risk information

Caution(s) and warning(s)

Contraindication(s)

Do not use this product if you are taking health products that affect blood coagulation as this may increase the risk of spontaneous bleeding (Brinker 2018; Bent 2005).

Known adverse reaction(s)

No statement required.

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage conditions

Must be established in accordance with the requirements described in the Natural Health Products Regulations (NHPR).

Specifications

References cited

References reviewed