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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.



August 5, 2019

Proper name(s), Common name(s), Source material(s)

Table 1. Proper name(s), Common name(s), Source material(s)
Proper name(s) Common name(s) Source material(s)
Proper name(s) Part(s) Preparation

Active hexose correlated compound

  • Active hexose correlated compound
  • AHCC

Lentinula edodes



References: Proper name: Spierings et al. 2007, Matsui et al. 2002; Common names: Spierings et al. 2007, Matsui et al. 2002; Source material: Fujii et al. 2011, Sumiyoshi et al. 2010.

Route of Administration


Dosage Form(s)

The acceptable dosage form is limited to powder.

This monograph excludes foods or food-like dosage forms as indicated in the Compendium of Monographs Guidance Document.

Use(s) or Purpose(s)

Source of/Provides antioxidants (Ye et al. 2004, 2003; Wang et al. 2001).



Adults 18 years and older


Method of preparation: Isolate

Not to exceed 3.6 grams of Active hexose correlated compound powder (AHCC-FD), per day (Fujii et al. 2011; Cowawintaweewat et al. 2006; Uno et al. 2000).

Direction(s) for use

Mix product well in at least 240 milliliters of liquid (e.g. water, milk, fruit juice or similar aqueous beverage) immediately before consumption.

Duration(s) of Use

No statement required.

Risk Information

Caution(s) and warning(s)

No statement required.


No statement required.

Known adverse reaction(s)

Stop use if symptoms such as nausea and diarrhea occur (Sumiyoshi et al. 2010; Matsui et al. 2002).

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage conditions

No statement required.


References Cited

References Reviewed