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McGuffin et al. 2000
Mills and Bone 2005
Route Of Administration
Those suited to the allowable route(s) of administration. This monograph is not intended to include food-like dosage forms such as bars, chewing gums or beverages.
Use(s) or Purpose(s)
Statement(s) to the effect of:
Dry, Powder, Decoction & Infusion + All Non-Standardised Extracts
0.2 - 3 Grams
dried herb tops
See Appendix 1 for examples of appropriate dosage preparations and frequencies of use, according to cited references. The purpose of Appendix 1 is to provide guidance to industry.
Duration of use
No statement is required
Statement(s) to the effect of:
Caution(s) and Warning(s)
Consult a health care practitioner if symptoms persist.
Consult a health care practitioner if symptoms worsen.
Consult a health care practitioner prior to use if you are breastfeeding
(Brinker 2010, Mills and Bone 2005)
Consumption with alcohol, other medications or natural health products with sedative and/or analgesic properties is not recommended
(Mills and Bone 2005, Hoffmann 2003, Brinker 2001)
Consult a health care practitioner if sleeplessness persists continuously for more than 3 weeks (chronic insomnia)
(Berardi et al. 2002, DiPiro et al. 2002)
Do not use if you are pregnant
, Blumenthal et al. 2000
Known Adverse Reaction(s)
Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness
(Mills and Bone 2005
, Felter and Lloyd 1983
Must be chosen from the current Natural Health Products Ingredients Database and must meet the limitations outlined in the database.
- The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of Natural Health Products Guide.
- The medicinal ingredient must comply with the requirements outlined in the Natural Health Products Ingredient Database (NHPID).
Berardi RR, DeSimone EM, Newton GD, Oszko MA, Popovich NG, Rollins CJ, Shimp LA, Tietze KJ, editors. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 13th edition. Washington (DC): American Pharmaceutical Association; 2002.
Blumenthal M, Goldberg A, Brinckmann J, editors. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
Brinker F. 2001. Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications.
Brinker F. 2010. Online Updates and Additions to Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications. [Updated 2010 July 13; Accessed 2013 January 30]. Available from: http://www.eclecticherb.com/emp/updatesHCDI.html
Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy: a pathophysiologic approach, 5th edition. New York (NY): The McGraw-Hill Companies, Inc.; 2002.
Felter HW, Lloyd JU. 1983. King's American Dispensatory, Volume 2, 18th edition. Sandy (OR): Eclectic Medical Publications [Reprint of 1898 original].
Hoffmann D. 2003. Medical Herbalism: The Science and Practice of Herbal Medicine. Rochester (VT): Healing Arts Press.
McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. 2000. Herbs of Commerce, 2nd edition. Austin(TX): American Herbal Products Association.
Mills S, Bone K. 2005. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone.
USDA 2008: ARS, National Genetic Resources Program. Germplasm Resources Information Network (GRIN). National Germplasm Resources Laboratory, Beltsville (MD). [Accessed 2008-01-21]. Available at http://www.ars-grin.gov/cgi-bin/npgs/html/tax_search.pl
McGuffin M, Hobbs C, Upton R, Goldberg A, editors. 1997. American Herbal Products Association's Botanical Safety Handbook. Boca Raton (FL): CRC Press.
Moore M. Medicinal Plants of the Pacific West. Santa Fe (NM): Red Crane Books, Inc.; 1993.
Sayre LE. A Manuel of Organic Materia Medica and Pharmacognosy, 4th edition. Philadelphia (PA): P. Blakiston's Son & Co; 1917. [Accessed 2008-02-14]. Available from: http://www.swsbm.com/SayreMM/SayreMM.html
Appendix 1: Examples of appropriate dosage preparations, frequencies of use and directions for use.
- 1.5-3.0 g dried equivalent, per day
(1:2, 3-6 ml) (Mills and Bone 2005)
- 0.2-0.8 g dried equivalent, per day
(1:5, 1-4 ml, 25% ethanol) (Hoffmann 2003)
Directions for use:
Take once at night (Hoffmann 2003).