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Drugs and Health Products

Monograph: Boldo

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Date: 2008-01-15

NHPID Name

Peumus boldus (USDA 2008)

Proper Name(s)

Peumus boldus Molina (Monimiaceae) ( USDA 2008 )

Common Name(s)

Boldo ( McGuffin et al. 2000 , Wiersema and León 1999 )

Source Material

Leaf ( Blumenthal et al. 2000 )

Route Of Administration

Oral

Dosage Form(s)

Those suited to the allowable route(s) of administration. This monograph is not intended to include food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s)

Statement(s) to the effect of:

Dose(s)

Adults:

Preparation: Dry, Powder, Decoction & Infusion + All Non-Standardised Extracts

Dose(s): 150 - 5000 Milligrams per day, dried leaf

See Appendix 1 for examples of appropriate dosage preparations and frequencies of use, according to cited references. The purpose of Appendix 1 is to provide guidance to industry.

Duration of use

Consult a health care practitioner for use beyond 4 weeks  (ESCOP 2003)

Risk Information

Statement(s) to the effect of:

Caution(s) and Warning(s):
  • Consult a health care practitioner if symptoms persist.
  • Consult a health care practitioner if symptoms worsen.
  • Consult a health care practitioner prior to use if you have impaired kidney or liver function  (Barnes et al. 2007, Bradley 2006, Brinker 2001)

Contraindication(s):
Do not use if you are pregnant or breastfeeding  (Brinker 2007, Bradley 2006, Mills and Bone 2005)

Known Adverse Reaction(s):
No statement is required

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database and must meet the limitations outlined in the database.

Specifications

  • The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of Natural Health Products Guide.
  • The medicinal ingredient must comply with the requirements outlined in the Natural Health Products Ingredient Database (NHPID).

References cited

  • Barnes J, Anderson LA, Philipson JD. 2007. Herbal Medicines, 3rd edition. London (GB): Pharmaceutical Press.
  • Blumenthal M, Goldberg A, Brinckmann J, editors. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
  • Bradley PR, editor. British Herbal Compendium: A Handbook of Scientific Information on Widely Used Plant Drugs, Volume 2. Bournemouth (UK): British Herbal Medicine Association; 2006.
  • Brinker F. 2001. Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications.
  • Brinker F. Online Updates and Additions to Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications; 2007. [Accessed 2007-11-21]. Available from: http://www.eclecticherb.com/emp/updatesHCDI.html
  • ESCOP 2003: ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products, 2nd edition. Exeter (UK): European Scientific Cooperative on Phytotherapy and Thieme; 2003.
  • Felter HW, Lloyd JU. King's American Dispensatory, Volume 1, 18th edition. Sandy (OR): Eclectic Medical Publications; 1983 [Reprint of 1898 original].
  • Hoffmann D. 2003. Medical Herbalism: The Science and Practice of Herbal Medicine. Rochester (VT): Healing Arts Press.
  • McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. 2000. Herbs of Commerce, 2nd edition. Austin(TX): American Herbal Products Association.
  • Mills S, Bone K. 2005. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone.
  • USDA 2008: ARS, National Genetic Resources Program. Germplasm Resources Information Network (GRIN). National Germplasm Resources Laboratory, Beltsville (MD). [Accessed 2008-01-21]. Available at http://www.ars-grin.gov/cgi-bin/npgs/html/tax_search.pl
  • Wiersema J, León B. 1999. World Economic Plants: A Standard Reference. Boca Raton (FL): CRC Press LLC.
  • Wren RC. 1907. Potter's Cyclopedia of Botanical Drugs and Preparations. London (GB): Potter and Clark.

References reviewed

  • Barnes J, Anderson LA, Philipson JD. 2002. Herbal Medicines: A Guide for Healthcare Professionals, 2nd edition. London (GB): The Pharmaceutical Press.
  • BHP 1983: British Herbal Pharmacopoeia. Cowling (GB): British Herbal Medical Association; 1983.
  • Bisset NG, Wichtl M, editors. Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis, 2nd edition. Stuttgart (D): Medpharm GmbH Scientific Publishers; 2001.
  • Grieve M. 1971. A Modern Herbal, Volume 1. New York (NY): Dover Publications [Reprint of 1931 Harcourt, Brace & Company publication].
  • Wichtl M, editor. Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis, 3rd edition. Stuttgart (D): Medpharm GmbH Scientific Publishers; 2004.

Appendix 1: Examples of appropriate dosage preparations, frequencies of use and directions for use

Dried leaf:

  • 60-200 mg, 3 times per day (Bradley 2006)
  • 200-3,000 mg, per day (Mills and Bone 2005)
  • 200-600 mg, per day (ESCOP 2003)
  • 3,000 mg, per day (Blumenthal et al. 2000)

Infusion:

  • 60-200 mg dried leaf, 3 times per day (Bradley 2006)
  • 200-3,000 mg, dried leaf, per day (Mills and Bone 2005)
  • 2,000-5,000 mg dried leaf, per day (ESCOP 2003)
  • 3,000 mg dried leaf, per day (Blumenthal et al. 2000)

Directions for use:

Pour 150 ml of boiling water on dried leaf and steep for 10 minutes (Blumenthal et al. 2000).

Fluidextract:

  • 100-300 mg dried equivalent, 3 times per day
    (1:1, 45% alcohol, 0.1-0.3 ml) (Bradley 2006)
  • 300-900 mg dried equivalent, per day
    (1:1, 0.3-0.9 ml) (Mills and Bone 2005)
  • 500-1,000 mg dried equivalent, per day
    (1:1, 80% ethanol, 0.5-1.0 ml) (ESCOP 2003)
  • 3,000 mg dried equivalent, per day
    (1:1, 3 ml) (Blumenthal et al. 2000)

Tincture:

  • 50-200 mg dried equivalent, 3 times per day
    (1:10, 60% alcohol, 0.5-2 ml) (Bradley 2006)
  • 350-1,000 mg dried equivalent, per day
    (1:2, 0.7-2 ml) (Mills and Bone 2005)
  • 300-1,200 mg dried equivalent, per day
    (1:5, 1.5-6 ml) (Mills and Bone 2005)
  • 180-600 mg dried equivalent, per day
    (1:10, 1.8-6 ml) (Mills and Bone 2005)
  • 200-600 mg dried equivalent, per day
    (1:5, 80% ethanol, 1-3 ml) (ESCOP 2003)
  • 200-400 mg dried equivalent, 3 times per day
    (1:5, 60% alcohol, 1-2 ml) (Hoffmann 2003)
  • 3,000 mg dried equivalent, per day
    (1:5, 15 ml) (Blumenthal et al. 2000)