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Drugs and Health Products

Monograph: Angelica

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Date: 2008-01-15

NHPID Name

Angelica archangelica (USDA 2008)

Proper Name(s)

Angelica archangelica L. (Apiaceae) ( USDA 2008 )

Common Name(s)

Source Material


Route Of Administration

Oral

Dosage Form(s)

Those suited to the allowable route(s) of administration. This monograph is not intended to include food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s)

Statement(s) to the effect of:

Dose(s)

Adults:

Preparation: Dry, Powder, Decoction & Infusion + All Non-Standardised Extracts

Dose(s): Leaf: 0.4 - 5 Grams 3 times per day, dried leaf
Dose(s): Root and rhizome: 0.3 - 12 Grams per day, dried root and rhizome
Dose(s): Seed: 1 - 2 Grams 3 times per day, dried seed

See Appendix 1 for examples of appropriate dosage preparations and frequencies of use, according to cited references. The purpose of Appendix 1 is to provide guidance to industry.

Duration of use

Diuretic: For occasional use only  (Berardi et al. 2002, CPA 2002)

Risk Information

Statement(s) to the effect of:

Caution(s) and Warning(s):
  • Avoid prolonged exposure to sunlight, ultraviolet light (UV) or UV therapy  (Barnes et al. 2007, Brinker 2001, Blumenthal et al. 2000)
  • Consult a health care practitioner if symptoms persist.
  • Consult a health care practitioner if symptoms worsen.
  • Consult a health care practitioner prior to use if you are breastfeeding  (Barnes et al. 2007)
  • Consult a health care practitioner prior to use if you have a peptic ulcer  (Brinker 2001)

Contraindication(s):
Do not use if you are pregnant  (Barnes et al. 2007, Brinker 2001, Blumenthal et al. 2000)

Known Adverse Reaction(s):
No statement is required

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database and must meet the limitations outlined in the database.

Specifications

  • The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of Natural Health Products Guide.
  • The medicinal ingredient must comply with the requirements outlined in the Natural Health Products Ingredient Database (NHPID).

References cited

  • Barnes J, Anderson LA, Philipson JD. 2007. Herbal Medicines, 3rd edition. London (GB): Pharmaceutical Press.
  • Berardi RR, DeSimone EM, Newton GD, Oszko MA, Popovich NG, Rollins CJ, Shimp LA, Tietze KJ, editors. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 13th edition. Washington (DC): American Pharmaceutical Association; 2002.
  • BHP 1983: British Herbal Pharmacopoeia. Cowling (GB): British Herbal Medical Association; 1983.
  • Blumenthal M, Busse W, Goldberg A, Gruenwald J, Hall T, Riggins C, Rister R, editors. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin (TX): American Botanical Council; 1998.
  • Blumenthal M, Goldberg A, Brinckmann J, editors. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
  • Bradley PR, editor. British Herbal Compendium: A Handbook of Scientific Information on Widely Used Plant Drugs, Volume 2. Bournemouth (UK): British Herbal Medicine Association; 2006.
  • Brinker F. 2001. Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications.
  • CPA 2002: Canadian Pharmacists Association. Patient Self-Care. Helping Patients Make Therapeutic Choices. Ottawa (ON): Canadian Pharmacists Association; 2002.
  • Felter HW, Lloyd JU. King's American Dispensatory, Volume 1, 18th edition. Sandy (OR): Eclectic Medical Publications; 1983 [Reprint of 1898 original].
  • Grieve M. 1971. A Modern Herbal, Volume 1. New York (NY): Dover Publications [Reprint of 1931 Harcourt, Brace & Company publication].
  • Hoffmann D. 2003. Medical Herbalism: The Science and Practice of Herbal Medicine. Rochester (VT): Healing Arts Press.
  • McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. 2000. Herbs of Commerce, 2nd edition. Austin(TX): American Herbal Products Association.
  • Mills S. The Dictionary of Modern Herbalsim. Wellingborough (UK): Thorsons Publishers Ltd; 1985.
  • USDA 2008: ARS, National Genetic Resources Program. Germplasm Resources Information Network (GRIN). National Germplasm Resources Laboratory, Beltsville (MD). [Accessed 2008-01-21]. Available at http://www.ars-grin.gov/cgi-bin/npgs/html/tax_search.pl
  • Wichtl M, editor. Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis, 3rd edition. Stuttgart (D): Medpharm GmbH Scientific Publishers; 2004.

References reviewed

  • Barnes J, Anderson LA, Philipson JD. 2002. Herbal Medicines: A Guide for Healthcare Professionals, 2nd edition. London (GB): The Pharmaceutical Press.
  • McGuffin M, Hobbs C, Upton R, Goldberg A, editors. 1997. American Herbal Products Association's Botanical Safety Handbook. Boca Raton (FL): CRC Press.
  • Mills S, Bone K. 2000. Principles and Practice of Phytotherapy. Toronto (ON): Churchill Livingstone.
  • Moerman DE . 1998. Native American Ethnobotany. Portland (OR): Timber Press.
  • Williamson EM, Evans FJ, Wren RC. Potter's New Cyclopaedia of Botanical Drugs and Preparations. Saffron Walden (GB): C.W. Daniel Company Limited; 1988.

Appendix 1: Examples of appropriate dosage preparations, frequencies of use and directions for use

Root and rhizome:

Dried root and rhizome:

  • 0.6-2 g, 3 times per day (Bradley 2006)
  • 4.5 g, per day (Blumenthal et al. 2000)
  • 1-2 g, 3 times per day (Blumenthal et al. 2000; Mills 1985)

Infusion:

  • 1-2 g dried root and rhizome, 3 times per day (Barnes et al. 2007)
  • 0.6-2 g dried root and rhizome, 3 times per day (Bradley 2006)
  • 2-4 g dried root and rhizome, 3 times per day (Blumenthal et al. 2000)

Directions for use:

Pour 150 ml of boiling water on dried root and rhizome and steep for approximately 10 minutes. Drink warm, one half-hour before meal times ( Blumenthal et al. 2000) .

Decoction:

1.5 g dried root and rhizome, 3 times per day ( Blumenthal et al. 2000 )

Directions for use:

Place dried root and rhizome in 150-250 ml of cold water, bring to a boil and simmer for approximately 10 minutes in a covered vessel. Drink warm, one half-hour before meal times ( Blumenthal et al. 2000 ) .

Fluidextract:

  • 0.5-2 g dried equivalent, 3 times per day
    (1:1, 25% alcohol, 0.5-2 ml) (Bradley 2006)
  • 1.5-3 g dried equivalent, per day
    (1:1, 1.5-3 ml) (Blumenthal 1998)

Tincture:

  • 100-400 mg dried equivalent, 3 times per day
    (1:5, 50% alcohol, 0.5-2 ml) (Bradley 2006)
  • 300 mg dried equivalent, per day
    (1:5, 1.5 ml) (Blumenthal et al. 1998)

Leaf:

Dried leaf:

2-5 g, 3 times per day (BHP 1983)

Infusion:

2-5 g dried leaf, 3 times per day (BHP 1983)

Fluidextract:

2-5 g dried equivalent, 3 times per day (1:1, 25% alcohol, 2-5 ml) (BHP 1983)

Tincture:

0.4-1 g dried equivalent, 3 times per day (1:5, 45% alcohol, 2-5 ml) (BHP 1983)

Seed (fruit):

Dried seed:

1-2 g, 3 times per day (Mills 1985)