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Drugs and Health Products

Monograph: Rosemary - Oral

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Date: 2008-01-23

NHPID Name

Rosmarinus officinalis (USDA 2008)

Proper Name(s)

Rosmarinus officinalis L. (Lamiaceae) ( USDA 2008 )

Common Name(s)

Rosemary ( McGuffin et al. 2000 )

Source Material

Leaf ( Blumenthal et al. 2000 )

Route Of Administration

Oral ( ESCOP 2003 )

Dosage Form(s)

Those suited to the allowable route(s) of administration. This monograph is not intended to include food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s)

Statement(s) to the effect of:

Dose(s)

Adults:

Preparation: Dry, Powder, Decoction & Infusion + All Non-Standardised Extracts

Dose(s): 0.6 - 12 Grams per day, dried leaf

See Appendix 1 for examples of appropriate dosage preparations and frequencies of use, according to cited references. The purpose of Appendix 1 is to provide guidance to industry.

Duration of use

No statement is required

Risk Information

Statement(s) to the effect of:

Caution(s) and Warning(s):
  • Consult a health care practitioner if symptoms persist.
  • Consult a health care practitioner if symptoms worsen.

Contraindication(s):
Do not use if you are pregnant or breastfeeding  (Barnes et al. 2007, Brinker 2001, Blumenthal et al. 2000, McGuffin et al. 1997)

Known Adverse Reaction(s):
No statement is required

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database and must meet the limitations outlined in the database.

Specifications

  • The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of Natural Health Products Guide.
  • The medicinal ingredient must comply with the requirements outlined in the Natural Health Products Ingredient Database (NHPID).

References cited

  • Barnes J, Anderson LA, Philipson JD. 2007. Herbal Medicines, 3rd edition. London (GB): Pharmaceutical Press.
  • BHP 1983: British Herbal Pharmacopoeia. Cowling (GB): British Herbal Medical Association; 1983.
  • Blumenthal M, Goldberg A, Brinckmann J, editors. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
  • Bradley PR, editor. British Herbal Compendium: A Handbook of Scientific Information on Widely Used Plant Drugs, Volume 2. Bournemouth (UK): British Herbal Medicine Association; 2006.
  • Brinker F. 2001. Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications.
  • ESCOP 2003: ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products, 2nd edition. Exeter (UK): European Scientific Cooperative on Phytotherapy and Thieme; 2003.
  • Grieve M. 1971. A Modern Herbal, Volume 1. New York (NY): Dover Publications [Reprint of 1931 Harcourt, Brace & Company publication].
  • Hoffmann D. 2003. Medical Herbalism: The Science and Practice of Herbal Medicine. Rochester (VT): Healing Arts Press.
  • McGuffin M, Hobbs C, Upton R, Goldberg A, editors. 1997. American Herbal Products Association's Botanical Safety Handbook. Boca Raton (FL): CRC Press.
  • McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. 2000. Herbs of Commerce, 2nd edition. Austin(TX): American Herbal Products Association.
  • Mills S, Bone K. 2005. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone.
  • Tilgner S. Herbal Medicine from the Heart of the Earth. Creswell (OR): Wise Acre Press; 1999.
  • USDA 2008: ARS, National Genetic Resources Program. Germplasm Resources Information Network (GRIN). National Germplasm Resources Laboratory, Beltsville (MD). [Accessed 2008-01-21]. Available at http://www.ars-grin.gov/cgi-bin/npgs/html/tax_search.pl
  • Wichtl M, editor. Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis, 3rd edition. Stuttgart (D): Medpharm GmbH Scientific Publishers; 2004.
  • Williamson EM, Evans FJ, Wren RC. Potter's New Cyclopaedia of Botanical Drugs and Preparations. Saffron Walden (GB): C.W. Daniel Company Limited; 1988.

Appendix 1: Examples of appropriate dosage preparations, frequencies of use and directions for use

ORAL:

Dried leaf:

  • 4 - 6 g, per day (Barnes et al. 2007)
  • 6 - 12 g, per day (Mills and Bone 2005)
  • 4 - 6 g, per day (Blumenthal et al. 2000)
  • 2 - 4 g, 3 times per day (BHP 1983)

Infusion:

  • 6 - 12 g dried leaf, per day (Mills and Bone 2005)
  • 2 - 4 g dried leaf, per day (ESCOP 2003)
  • 2 g dried leaf, 3 times per day (Blumenthal et al. 2000)
  • 2 - 4 g dried leaf, 3 times per day (BHP 1983)

Directions for use:

Pour 150 ml of boiling water on dried leaf and infuse (Blumenthal et al. 2000).

Fluid extract:

  • 6 - 12 g dried equivalent, per day (1:1, 6-12 ml) (Mills and Bone 2005)
  • 1.5 - 3 g dried equivalent, per day (1:1, 45% ethanol, 1.5-3 ml) (ESCOP 2003)
  • 2 g dried equivalent, 3 times per day (1:1, 2 ml) (Blumenthal et al. 2000)
  • 2 - 4 g dried equivalent, 3 times per day (1:1, 45% alcohol, 2-4 ml) (BHP 1983)

Tincture:

  • 0.6 - 1.7 g dried equivalent, per day (1:5, 70% ethanol, 3-8.5 ml) (ESCOP 2003)
  • 0.2 - 0.4 g dried equivalent, 3 times per day (1:5, 40% ethanol, 1-2 ml) (Hoffmann 2003)
  • 2 g dried equivalent, 3 times per day (1:5, 10 ml) (Blumenthal et al. 2000)