Monograph: Propolis - Oral

Date: 2018-07-31

NHPID name

Propolis ( Integrated Taxonomic Information System )

Proper name(s)

Common name(s)

Propolis - Oral

Source material

Route Of administration

Oral

Dosage form(s)

• The acceptable pharmaceutical dosage forms include, but are not limited to capsules, chewables (e.g. gummies, tablets), liquids, powders, strips or tablets.
• This monograph is not intended to include foods or food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or purpose(s)

Statement(s) to the effect of:

• Source of/Provides antioxidants.  (Jasprica et al. 2007, Lofty 2006, PRC 2005, Kwon et al. 2004, Ichikawa et al. 2002, Tilgner 1999)
• (Traditionally) used in Herbal Medicine to help relieve sore throat and/or other mouth and throat infections.  (PRC 2005, Castalado and Capasso 2002, Mills and Bone 2000, Tilgner 1999)

Dose(s)

Duration of use

Consult a health care practitioner/health care provider/health care professional/doctor/physician for use beyond 1 month.  (Jasprica et al. 2007)

Risk information

Statement(s) to the effect of:

Caution(s) and Warning(s):

• Consult a health care practitioner/health care provider/health care professional/doctor/physician if symptoms persist or worsen.
• Consult a health care practitioner/health care provider/health care professional/doctor/physician prior to use if you are pregnant or breastfeeding or if you are allergic to bee products, poplar tree products, or balsam of Peru.

Contraindication(s): No statement is required Known Adverse Reaction(s): Stop use immediately if hypersensitivity/allergy occurs.

Non-medicinal ingredients

Must be chosen from the current Natural health products ingredients database and must meet the limitations outlined in the database.

Specifications

• The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of natural health products guide.
• The medicinal ingredient must comply with the requirements outlined in the Natural health products ingredient database (NHPID).
• The medicinal ingredient may comply with the specifications outlined in the Propolis monograph published in the Pharmacopoeia of the People's Republic of China.

References cited

• Brinker F. 2001. Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications.
• Castalado S, Capasso F. 2002. Propolis, an old remedy used in modern medicine. Fitotherapia 73(S1):S1-S6
• Hausen BM et al. 1987. Propolis allergy (II): the sensitizing properties of 1,1-dimethylallyl caffeic acid ester. Contact Dermatitis 17:171-177.
• Hsu CY, Chiang WC, Weng TI, Chen WJ, Yuan A. 2004. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. American Journal of Emergency Medicine 22(5):432-433.
• Ichikawa H, Satoh K, Tobe K, Yasuda I, Ushio F, Matsumoto K, Endo K, Ookubo C. 2002. Free radical scavenging activity of propolis. Redox Report 7(5): 347-350.
• Jasprica I, Mornar A, Debeljak Z, Molcic-Bubalo A, Medic-Saric M, Mayer L, Romic Z, Bucan K, Balog T, Sobocanec S, Sverko V. 2007. In vivo study of propolis supplementation effects on antioxidative status and red blood cells. Journal of Ethnopharmacology 110:548-554.
• Kwon YS, Park DH, Shin EJ, Kwon MS, Ko KH, Kim WK, Jhoo JH, Hjoo WK, Wie MB, Jung BD, Kim HC. 2004. Antioxidant propolis attenuates kainite-induced neurotoxicity via adenosine A1 receptor modulation in the rat. Neuroscience Letters; 355:231-235.
• Lotfy M. 2006. Review: Biological activity of bee propolis in health and disease. Asian Pacific Journal of Cancer Prevention 7:22-31.
• Machackova J. 1988. The incidence of allergy to propolis in 605 consecutive patients patch tested in Prague. Contact Dermatitis 18:210-212.
• Marcucci MC. 1995. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie 26:83-89.
• Melli MC, Giorgini S, Sertoli A. 1983. Occupational dermatitis in a bee-keeper. Contact Dermatitis 9(5):427-428.
• Mills S, Bone K. 2000. Principles and Practice of Phytotherapy. Toronto (ON): Churchill Livingstone.
• Peirce A. Practical Guide to Natural Medicines. New York (NY): The Stonesong Press, Inc; 1999.
• PPRC 2005: Pharmacopoeia of the People's Republic of China, Volume I. Beijing (CN): Chinese Pharmacopoeia Commission.
• Ramos AFN, Miranda JL. 2007. Propolis: a review of its anti-inflammatory and healing actions. J. Venom. Anim. Toxins incl. Trop. Dis. 13(4):697-710.
• Rudzki E, Grzywa Z. 1983. Dermatitis from propolis. Contact Dermatitis 9(1):40-45.
• Salatino A, Teixeira EW, Negri G, Message D. 2005. Review: Origin and chemical variation of Brazilian propolis. Oxford University Press eCAM 2(1):33-38.
• Samet N, Laurent C, Susarla SM, Samet-Rubinsteen N. 2007. The effect of bee propolis on recurrent aphthous stomatitis: a pilot study. Clinical Oral Investigation 11:143-147.
• Scully C. 2006. Propolis: A background (Letter). British Dental Journal 200(7):359-360.
• Teraki Y and Shiohara T. 2001. Propolis-induced granulomatous contact dermatitis accompanied by marked lymphadenopathy. British Journal of Dermatology 144:1277-1278.
• Tilgner S. Herbal Medicine from the Heart of the Earth. Creswell (OR): Wise Acre Press; 1999.
• Valsecchi R, Cainelli T. 1984. Dermatitis from propolis. Contact Dermatitis 11(5):317.

References reviewed

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• Burdock GA. 1998. Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology 36:347-363.
• Cairo do Amaral R, Gomes RT, Rocha WMS, Abreu SLR, Santos VR. 2006. Periodontitis treatment with Brazilian green propolis gel. Pharmacologyonline 3:336-341.
• Coelho LG, Bastos EMAF, Resende CC, Paula e Silva CM, Sanches BSF, Castro FJ, Moretzsohn LD, Vieira WLS, Trinidade OR. 2007. Brazilian green propolis on Helicobacter pylori infection. A pilot clinical study. Helicobacter 12:572-574.
• Crisan I, Zaharia CN, Popovici F, Jucu V, Belu O, Dascalu C, Mutiu A, Petrescu A. 1995. Natural propolis extract NIVCRISOL in the treatment of acute and chronic rhinopharyngitis in children. Romanian Journal of Virology 46(3-4):115-133.
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• Fuliang HU, Hepburn HR, Xuan H, Chen M, Daya S, Radloff SE. 2005. Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus. Pharmacological Research 51:147-152.
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• ITIS 2009: Integrated Taxonomic Information System, Canadian Biodiversity Information Facility, Government of Canada [Accessed 2009-10-21]. Available from: http://www.cbif.gc.ca/pls/itisca/taxaget?p_ifx=cbif
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• Khayyal MT, El-Ghazaly MA, El-Khatib AS, Hatem AM, de Vries PJF, El-Shafei S, Khattab MM. 2003. A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Fundamental and Clinical Pharmacology 17:93-102.
• Koo H, Cury JA, Rosalen PL, Ambrosano GMB, Ikegaki M, Park YK. 2002. Effect of a mouthrinse containing selected propolis on 3-day dental plaque accumulation and polysaccharide formation. Caries Research 36(6):445-448.
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