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Drugs and Health Products

Monograph: Pantothenic Acid

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Date: 2007-08-16


D-Pantothenic acid (USNLM 2007)

Proper Name(s)

D-Pantothenic acid ( Sweetman 2007 )

Common Name(s)

Source Material

The slash (/) indicates that the terms are synonyms. Either term may be selected by the applicant

Route Of Administration


Dosage Form(s)

  • The acceptable pharmaceutical dosage forms include, but are not limited to capsules, chewables (e.g. gummies, tablets), liquids, powders, strips or tablets.
  • This monograph is not intended to include foods or food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s)

Statement(s) to the effect of:

A factor in the maintenance of good health  (IOM 2006, IOM 1998)


For products providing daily doses of Pantothenic Acid at or above the Adequate Intake (AI):
Helps to prevent pantothenic acid deficiency  (IOM 2006, Shils et al. 2006, Groff and Gropper 2000, IOM 1998)


Children and adolescents 1 - 13 years:

Dose(s): 0.2 - 500 Milligrams per day

Adults and adolescents 14 and over:

Dose(s): 0.4 - 500 Milligrams per day

  • Adults includes pregnant and breastfeeding women.
  • Conversion factors (USP 30) --- Table 2: Conversion of pantothenic acid source material quantity into pantothenic acid quantity: Source material (1 mg) = Pantothenic acid quantity (mg) * d-Pantothenic acid (1 mg) = 1.00 mg of pantothenic acid * d-Panthenol (1 mg) = 1.07 mg of pantothenic acid * Calcium-d-pantothenate (1 mg) = 0.92 mg of pantothenic acid * dl-Pantothenic acid (1 mg) = 0.50 mg of pantothenic acid * dl-Panthenol (1 mg) = 0.54 mg of pantothenic acid * Calcium-dl-pantothenate (1 mg) = 0.46 mg of pantothenic acid
  • The daily minimum doses are based on approximately 5% of the highest RDA (IOM 2006). See Appendix 1 for definitions and Table 3 in Appendix 2 for RDA values.
  • The maximum daily doses are supported by the following reference: HC 2006.

Duration of use

No statement is required

Risk Information

Statement(s) to the effect of:

Caution(s) and Warning(s):
No statement is required

No statement is required

Known Adverse Reaction(s):
No statement is required

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database and must meet the limitations outlined in the database.


  • The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of Natural Health Products Guide.
  • The medicinal ingredient must comply with the requirements outlined in the Natural Health Products Ingredient Database (NHPID).

References cited

  • Groff J, Gropper S. Advanced Nutrition and Human Metabolism, 3rd edition. Belmont (CA): Wadsworth/Thomson Learning; 2000.
  • HC 2006: Health Canada. NHPD Expert Advisory Committee Issue Analysis Summary: What is an appropriate maximum daily dose for pantothenic acid? Ottawa (ON): Natural Health Products Directorate, Health Canada; 2006.
  • IOM 1998: Institute of Medicine. Panel on Folate, other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline. Washington (DC): National Academies Press; 1998.
  • IOM 2003: Institute of Medicine. Committee on Food Chemicals Codex, Food and Nutrition Board, Institute of Medicine. Food Chemicals Codex, 5th edition. Washington (DC): National Academies Press; 2003.
  • IOM 2006: Institute of Medicine. Otten JJ, Pitzi Hellwig J, Meyers LD, editors. Institute of Medicine. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington (DC): National Academies Press; 2006.
  • O'Neil MJ, Smith A, Heckelman PE, Budavari S, editors. The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 13th edition. Whitehouse Station (NJ): Merck & Co., Inc.; 2001.
  • Shils ME, Olson JA, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern Nutrition in Health and Disease, 10th edition. Philadelphia (PA): Lippincott Williams & Wilkins; 2006.
  • Sweetman SC , editor. Martindale: The Complete Drug Reference, 35th edition. London (UK): Pharmaceutical Press; 2007.
  • USP 30: United States Pharmacopeia and the National Formulary (USP 30 - NF 25). Rockville (MD): United States Pharmacopeial Convention, Inc.; 2007.

Appendix 1: Definitions

Adequate Intake (AI):

The recommended average daily intake level based on observed or experimentally determined approximations or estimates of nutrient intake by a group (or groups) of apparently healthy people that are assumed to be adequate; used when a Recommended Dietary Allowance (RDA) cannot be determined (IOM 2006).

Recommended Dietary Allowances (RDA):

The average daily dietary nutrient intake level sufficient to meet the nutrient requirements of nearly all (97-98%) healthy individuals in a particular life stage and gender group (IOM 2006).

Appendix 2: AI Values

The AI values for pantothenic acid are provided below. For the purpose of this monograph, these values are intended to:

  • provide targets for setting appropriate supplement dosage levels;
  • provide the minimum dose for the use of the dose-specific use or purpose: "Helps to prevent pantothenic acid deficiency";
  • facilitate the optional labelling of % AI values.

Table 3: Adequate Intake values for pantothenic acid based on life stage group (IOM 2006)

Table 1: Adequate Intake values for pantothenic acid based on life stage group (IOM 2006)
Life stage group Pantothenic acid (mg/day)
Children 1-3 y 2
4-8 y 3
Adolescents 9-13 y 4
14-18 y 5
Adults ≥ 19 y 5
Pregnancy 14-50 y 6
Breastfeeding 14-50 y 7