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Drugs and Health Products

Monograph: Horseradish

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Date: 2008-02-15

NHPID Name

Armoracia rusticana (USDA 2008)

Proper Name(s)

Armoracia rusticana P. Gaertn. et al. (Brassicaceae) ( USDA 2008 )

Common Name(s)

Horseradish ( McGuffin et al. 2000 , Felter and Lloyd 1983[1898] )

Source Material

Root ( Barnes et al. 2007 , Blumenthal et al. 2000 , Grieve 1971[1931] , Wren 1907 )

Route Of Administration

Oral

Dosage Form(s)

Those suited to the allowable route(s) of administration. This monograph is not intended to include food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s)

Statement(s) to the effect of:

Dose(s)

Adults:

Preparation: Dry, Powder, Decoction & Infusion + All Non-Standardised Extracts

Dose(s): 2 - 20 Grams per day, root

See Appendix 1 for examples of appropriate dosage preparations and frequencies of use, according to cited references. The purpose of Appendix 1 is to provide guidance to industry.

Duration of use

Diuretic: For occasional use only  (Berardi et al. 2002, CPA 2002)

Risk Information

Statement(s) to the effect of:

Caution(s) and Warning(s):
  • Consult a health care practitioner if symptoms persist.
  • Consult a health care practitioner if symptoms worsen.
  • Consult a health care practitioner prior to use if you are breastfeeding  (Barnes et al. 2007, Blumenthal et al. 2000)
  • Consult a health care practitioner prior to use if you have excess stomach acid or gastroesophageal reflux or if you are taking antacids  (Brinker 2001)
  • Consult a health care practitioner prior to use if you have hypothyroidism or if you are taking thyroid replacement medications  (Barnes et al. 2007, Brinker 2001, Mills 1985)

Contraindication(s):

Known Adverse Reaction(s):
No statement is required

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database and must meet the limitations outlined in the database.

Specifications

  • The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of Natural Health Products Guide.
  • The medicinal ingredient must comply with the requirements outlined in the Natural Health Products Ingredient Database (NHPID).

References cited

  • Barnes J, Anderson LA, Philipson JD. 2007. Herbal Medicines, 3rd edition. London (GB): Pharmaceutical Press.
  • Berardi RR, DeSimone EM, Newton GD, Oszko MA, Popovich NG, Rollins CJ, Shimp LA, Tietze KJ, editors. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 13th edition. Washington (DC): American Pharmaceutical Association; 2002.
  • Blumenthal M, Goldberg A, Brinckmann J, editors. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
  • Brinker F. 2001. Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications.
  • Brinker F. Online Updates and Additions to Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications; 2007. [Accessed 2007-11-21]. Available from: http://www.eclecticherb.com/emp/updatesHCDI.html
  • CPA 2002: Canadian Pharmacists Association. Patient Self-Care. Helping Patients Make Therapeutic Choices. Ottawa (ON): Canadian Pharmacists Association; 2002.
  • Felter HW, Lloyd JU. King's American Dispensatory, Volume 1, 18th edition. Sandy (OR): Eclectic Medical Publications; 1983 [Reprint of 1898 original].
  • Grieve M. 1971. A Modern Herbal, Volume 1. New York (NY): Dover Publications [Reprint of 1931 Harcourt, Brace & Company publication].
  • McGuffin M, Hobbs C, Upton R, Goldberg A, editors. 1997. American Herbal Products Association's Botanical Safety Handbook. Boca Raton (FL): CRC Press.
  • McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. 2000. Herbs of Commerce, 2nd edition. Austin(TX): American Herbal Products Association.
  • Meyer JE. The Herbalist. Glenwood (IL): Meyerbooks; 1993.
  • Mills S. The Dictionary of Modern Herbalsim. Wellingborough (UK): Thorsons Publishers Ltd; 1985.
  • Moerman DE . 1998. Native American Ethnobotany. Portland (OR): Timber Press.
  • USDA 2008: ARS, National Genetic Resources Program. Germplasm Resources Information Network (GRIN). National Germplasm Resources Laboratory, Beltsville (MD). [Accessed 2008-01-21]. Available at http://www.ars-grin.gov/cgi-bin/npgs/html/tax_search.pl
  • Wren RC. 1907. Potter's Cyclopedia of Botanical Drugs and Preparations. London (GB): Potter and Clark.

References reviewed

  • Hoffmann D. 2003. Medical Herbalism: The Science and Practice of Herbal Medicine. Rochester (VT): Healing Arts Press.
  • Mills S, Bone K. 2000. Principles and Practice of Phytotherapy. Toronto (ON): Churchill Livingstone.
  • Williamson EM, Evans FJ, Wren RC. Potter's New Cyclopaedia of Botanical Drugs and Preparations. Saffron Walden (GB): C.W. Daniel Company Limited; 1988.
  • Williamson EM. Potter's Herbal Cyclopaedia: The Authoritative Reference work on Plants with a Known Medical Use. Saffron Walden (UK): The C.W. Daniel Company Limited; 2003.

Appendix 1: Examples of appropriate dosage preparations, frequencies of use and directions for use

Fresh root:

2-4 g, 3 times per day (Mills 1985)

Direction for use:

Take before meals (Mills 1985).

Fresh or dried root:

20 g, per day (Blumenthal et al. 2000)

Infusion:

2 g root, several times per day (Blumenthal et al. 2000)

Direction for use:

Pour 150 ml of boiling water over root and infuse for 5 minutes (Blumenthal et al. 2000).

Tincture:

2-4 g dried equivalent, per day (Grieve 1971 [1931]; Wren 1907)

Syrup:

2 g root, per day (Blumenthal et al. 2000)

Direction for use:

Prepare a concentrated infusion by steeping root in 150 ml of boiled water in a covered cup for two hours. Strain and add an equal amount of sugar (150 g) to liquid (150 ml) to thicken (Blumenthal et al. 2000).