Monograph: Glucosamine sulfate

Date: 2022-03-11

NHPID name

Glucosamine sulfate ( ChemIDplus Advanced )

Proper name(s)

2-Amino-2-deoxy-D-glucose sulfate ( NLM 2009 )

Common name(s)

Glucosamine sulfate ( USP 2008 , Sweetman 2007 , Towheed et al. 2007 )

Source material

• Crab - Exoskeleton (ITIS 2009, Kralovec and Barrow 2008)
• Lobster - Exoskeleton (ITIS 2009, Kralovec and Barrow 2008)
• Prawn - Exoskeleton (Unavailable)
• Shrimp - Exoskeleton (Unavailable)

Route Of administration

Oral

Dosage form(s)

• The acceptable pharmaceutical dosage forms include, but are not limited to capsules, chewables (e.g. gummies, tablets), liquids, powders, strips or tablets.
• This monograph is not intended to include foods or food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or purpose(s)

Statement(s) to the effect of:

• Helps protect against the deterioration of cartilage and relieve joint pain associated with osteoarthritis.
• Helps to relieve joint pain associated with osteoarthritis.  (Herrero-Beaumont et al. 2007, Usha and Naidu 2004, Pavelka et al. 2002, Reginster et al. 2001, Thie et al. 2001)
• Helps to relieve pain associated with osteoarthritis of the knee.  (Herrero-Beaumont et al. 2007, Usha and Naidu 2004, Pavelka et al. 2002, Reginster et al. 2001)
• Helps to protect against the deterioration of cartilage.  (Pavelka et al. 2002, Reginster et al. 2001)
• A factor in maintaining good cartilage and/or joint health.  (Towheed et al. 2007, Pavelka et al. 2002, Reginster et al. 2001)

Dose(s)

Adults:

Duration of use

Use for at least 4 weeks to see beneficial effects.

Risk information

Statement(s) to the effect of:

Caution(s) and Warning(s):

• Consult a health care practitioner/health care provider/health care professional/doctor/ physician if symptoms worsen.
• Consult a health care practitioner/health care provider/health care professional/doctor/ physician prior to use if you are pregnant or breastfeeding.

Contraindication(s): No statement is required Known Adverse Reaction(s): No statement is required

Non-medicinal ingredients

Must be chosen from the current Natural health products ingredients database and must meet the limitations outlined in the database.

Specifications

• The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of natural health products guide.
• The medicinal ingredient must comply with the requirements outlined in the Natural health products ingredient database (NHPID).
• The medicinal ingredient may comply with the specifications outlined in the Glucosamine Tablets, Glucosamine Sulfate Potassium Chloride and Glucosamine Sulfate Sodium Chloride monographs published in the U.S. Pharmacopoeia.

References cited

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• Herrero-Beaumont G, Ivorra JAR, Trabado MC, Blanco FJ, Benito P, Martín-Mola E, Paulino J, Marenco JL, Porto A, Laffon A, Araújo D, Figueroa M, Branco J. 2007. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms- a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis and Rheumatism 56(2):555-567
• Houpt JB, McMillan R, Wein C, Paget-Dellio SD. 1999. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. Journal of rheumatology 26(11):2423-2430
• ITIS 2009: Integrated Taxonomic Information System, Canadian Biodiversity Information Facility, Government of Canada [Accessed 2009-10-21]. Available from: http://www.cbif.gc.ca/pls/itisca/taxaget?p_ifx=cbif
• Kralovec A, Barrow CJ. 2008. Glucosamine Production and Health Benefits. Dans: Marine Nutraceuticals and Functional Foods. Colin Barrow and Fereidoon Shahidi, éditeurs, pp198-227. Boca Raton (FL): CRC Press, Taylor and Francis Group
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• NLM 2009: United States National Library of Medicine. ChemIDplus advanced [online]. Chemical name. RN: 000-00-0. Bethesda (MD): Specialized Information Services, United States National Library of Medicine, National Institutes of Health, United States Department of Health & Human Services. [Accessed 2009 May 19]. Available from: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?CHEM
• Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. 2002. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Archives of Internal Medicine 162(18):2113-2123.
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• Thie NM, Prasad NG, Major PW. 2001. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temperomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. The Journal of Rheumatology 28:1347-1355
• Towheed, TE, Anastassiades T. 2007. Glucosamine Therapy for Osteoarthritis: An Update. The Journal of Rheumatology 34(9):1787-1790
• Usha PR, Naidu MUR. 2004. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug Investigation 24(6):353-363.
• USP 32 : United States Pharmacopeial Convention. 2009. United States Pharmacopeia and the National Formulary (USP 32 - NF 27). Rockville (MD): The United States Pharmacopeial Convention.

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