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Monograph: Glucosamine sulfate

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient. It is a referenced document to be used as a labelling standard. Note: Text in parentheses is additional optional information which can be included on the Product Licence Application and product labels at the applicants' discretion. The solidus (/) indicates that the terms are synonyms or that the statements are synonymous. Either term or statement may be selected by the applicant.

Date: 2018-08-27


Glucosamine sulfate (USNLM 2007)

Proper Name(s)

2-Amino-2-deoxy-D-glucose sulfate ( NLM 2009 )

Common Name(s)

Glucosamine sulfate ( USP 2008 , Sweetman 2007 , Towheed et al. 2007 )

Source Material

Route Of Administration


Dosage Form(s)

  • The acceptable pharmaceutical dosage forms include, but are not limited to capsules, chewables (e.g. gummies, tablets), liquids, powders, strips or tablets.
  • This monograph is not intended to include foods or food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s)

Statement(s) to the effect of:



Dose(s): 1 Day per day

Duration of use

Use for at least 4 weeks to see beneficial effects.

Risk Information

Statement(s) to the effect of:

Caution(s) and Warning(s):
  • Consult a health care practitioner/health care provider/health care professional/doctor/ physician if symptoms worsen.
  • Consult a health care practitioner/health care provider/health care professional/doctor/ physician prior to use if you are pregnant or breastfeeding.

No statement is required

Known Adverse Reaction(s):
No statement is required

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database and must meet the limitations outlined in the database.


  • The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of Natural Health Products Guide.
  • The medicinal ingredient must comply with the requirements outlined in the Natural Health Products Ingredient Database (NHPID).
  • The medicinal ingredient may comply with the specifications outlined in the Glucosamine Tablets, Glucosamine Sulfate Potassium Chloride and Glucosamine Sulfate Sodium Chloride monographs published in the U.S. Pharmacopoeia.

References cited

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  • Houpt JB, McMillan R, Wein C, Paget-Dellio SD. 1999. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. Journal of rheumatology 26(11):2423-2430
  • ITIS 2009: Integrated Taxonomic Information System, Canadian Biodiversity Information Facility, Government of Canada [Accessed 2009-10-21]. Available from:
  • Kralovec A, Barrow CJ. 2008. Glucosamine Production and Health Benefits. Dans: Marine Nutraceuticals and Functional Foods. Colin Barrow and Fereidoon Shahidi, éditeurs, pp198-227. Boca Raton (FL): CRC Press, Taylor and Francis Group
  • Mehta K, Gala J, Bhasale S, Naik S, Modak M, Thakur H, Deo N, Miller JM. 2007. Comparison of glucosamine sulphate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial. BMC Complementary and alternative Medicine 31(7):34
  • NLM 2009: United States National Library of Medicine. ChemIDplus advanced [online]. Chemical name. RN: 000-00-0. Bethesda (MD): Specialized Information Services, United States National Library of Medicine, National Institutes of Health, United States Department of Health & Human Services. [Accessed 2009 May 19]. Available from:
  • Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. 2002. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Archives of Internal Medicine 162(18):2113-2123.
  • Qiu GX, Gao SN, Giocovelli G, Rovati L, Stenikar I. 1998. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimmittelforschung 48:460-474
  • Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JA, Gossett C. 2001. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. The Lancet 357:251-256
  • Sivojelezova A, Koren G, Einarson A. 2007. Glucosamine Use in Pregnancy: An Evaluation of Pregnancy Outcome. Journal of Women's Health 16(3):345-348
  • Sweetman SC , editor. Martindale: The Complete Drug Reference, 35th edition. London (UK): Pharmaceutical Press; 2007.
  • Thie NM, Prasad NG, Major PW. 2001. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temperomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. The Journal of Rheumatology 28:1347-1355
  • Towheed, TE, Anastassiades T. 2007. Glucosamine Therapy for Osteoarthritis: An Update. The Journal of Rheumatology 34(9):1787-1790
  • Usha PR, Naidu MUR. 2004. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug Investigation 24(6):353-363.
  • USP 32 : United States Pharmacopeial Convention. 2009. United States Pharmacopeia and the National Formulary (USP 32 - NF 27). Rockville (MD): The United States Pharmacopeial Convention.

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