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Drugs and Health Products

Monograph: Globe artichoke

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Date: 2008-04-10


Cynara cardunculus (USDA 2008)

Proper Name(s)

Common Name(s)

Source Material

Leaf ( Bradley 2006 , ESCOP 2003 , Blumenthal et al. 2000 )

Route Of Administration


Dosage Form(s)

Those suited to the allowable route(s) of administration. This monograph is not intended to include food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s)

Statement(s) to the effect of:



Preparation: Dry, Powder, Decoction & Infusion + All Non-Standardised Extracts

Dose(s): 1.5 - 10 Grams per day, dried leaf

See Appendix 1 for examples of appropriate dosage preparations and frequencies of use, according to cited references. The purpose of Appendix 1 is to provide guidance to industry.

Duration of use

No statement is required

Risk Information

Statement(s) to the effect of:

Caution(s) and Warning(s):


Known Adverse Reaction(s):
Hypersensitivity (e.g. allergy) has been known to occur; in which case, discontinue use  (Brinker 2010, Bradley 2006, ESCOP 2003, Blumenthal et al. 2000)

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database and must meet the limitations outlined in the database.


  • The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of Natural Health Products Guide.
  • The medicinal ingredient must comply with the requirements outlined in the Natural Health Products Ingredient Database (NHPID).
  • The medicinal ingredient may comply with the specifications outlined in the Artichoke Leaf Monograph published in the British Pharmacopoeia.

References cited

  • Barnes J, Anderson LA, Philipson JD. 2007. Herbal Medicines, 3rd edition. London (GB): Pharmaceutical Press.
  • Blumenthal M, Goldberg A, Brinckmann J, editors. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
  • Bradley PR, editor. British Herbal Compendium: A Handbook of Scientific Information on Widely Used Plant Drugs, Volume 2. Bournemouth (UK): British Herbal Medicine Association; 2006.
  • Brinker F. 2001. Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications.
  • Brinker F. 2010. Online Updates and Additions to Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications. [Updated 2010 July 13; Accessed 2013 January 30]. Available from:
  • ESCOP 2003: ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products, 2nd edition. Exeter (UK): European Scientific Cooperative on Phytotherapy and Thieme; 2003.
  • Hoffmann D. 2003. Medical Herbalism: The Science and Practice of Herbal Medicine. Rochester (VT): Healing Arts Press.
  • McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. 2000. Herbs of Commerce, 2nd edition. Austin(TX): American Herbal Products Association.
  • Mills S, Bone K. 2005. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone.
  • USDA 2008: ARS, National Genetic Resources Program. Germplasm Resources Information Network (GRIN). National Germplasm Resources Laboratory, Beltsville (MD). [Accessed 2008-01-21]. Available at

References reviewed

Sinayoko L, Mennecier D, El Jahir Y, Corberand D, Harnois F, Thiolet C, Farret O. [Acute hepatic injury secondary to ingestion of artichoke extracts (Hepanephrol).] Atteinte hépatique aiguë secondaire à la prise d'extraits d'artichaut (Hépanéphrol®). Gastroentérologie clinique et biologique 2007; 31(11):1039-1040 (in French).

Appendix 1: Examples of appropriate dosage preparations and frequencies of use

Dried leaf:

6 g, per day (Blumenthal et al. 2000)


5-10 g dried leaf, per day (ESCOP 2003)


1.5-4 g dried equivalent, per day
(1:2, 3-8 ml) (Mills and Bone 2005)

Dry aqueous extract:

  • 4.5-9 g dried equivalent, per day (Bradley 2006)
  • 5-10 g dried equivalent, per day (ESCOP 2003)