Monograph: Globe artichoke

Help on accessing alternative formats, such as Portable document format (PDF), Microsoft word and PowerPoint (PPT) files, can be obtained in the alternate format help section.

Date: 2018-12-18

NHPID name

Cynara cardunculus ( Germplasm Resources Information Network Taxonomy )

Proper name(s)

Cynara cardunculus ( USDA 2008 )

Common name(s)

Source material

Leaf ( Bradley 2006 , ESCOP 2003 , Blumenthal et al. 2000 )

Route Of administration

Oral

Dosage form(s)

Those suited to the allowable route(s) of administration. This monograph is not intended to include food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or purpose(s)

Statement(s) to the effect of:

Dose(s)

Adults:

Dose(s):

1 Day per day

See Appendix 1 for examples of appropriate dosage preparations and frequencies of use, according to cited references. The purpose of Appendix 1 is to provide guidance to industry.

Duration of use

No statement is required

Risk information

Statement(s) to the effect of:

Caution(s) and Warning(s): Contraindication(s): Do not use this product if you have a bile duct obstruction.  (Brinker 2010, Bradley 2006, ESCOP 2003, Blumenthal et al. 2000) Known Adverse Reaction(s): Stop use if hypersensitivity/allergy occurs.  (Brinker 2010, Bradley 2006, ESCOP 2003, Blumenthal et al. 2000)

Non-medicinal ingredients

Must be chosen from the current Natural health products ingredients database and must meet the limitations outlined in the database.

Specifications

References cited

References reviewed

Sinayoko L, Mennecier D, El Jahir Y, Corberand D, Harnois F, Thiolet C, Farret O. [Acute hepatic injury secondary to ingestion of artichoke extracts (Hepanephrol).] Atteinte hépatique aiguë secondaire à la prise d'extraits d'artichaut (Hépanéphrol®). Gastroentérologie clinique et biologique 2007; 31(11):1039-1040 (in French).

Appendix 1: Examples of appropriate dosage preparations and frequencies of use

Dried leaf:

6 g, per day (Blumenthal et al. 2000)

Infusion:

5-10 g dried leaf, per day (ESCOP 2003)

Tincture:

1.5-4 g dried equivalent, per day
(1:2, 3-8 ml) (Mills and Bone 2005)

Dry aqueous extract: