Monograph: Globe artichoke
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Date:
2018-12-18
See Appendix 1 for examples of appropriate dosage preparations and frequencies of use, according to cited references. The purpose of Appendix 1 is to provide guidance to industry.
NHPID name
Cynara cardunculus ( Germplasm Resources Information Network Taxonomy )Proper name(s)
Cynara cardunculus ( USDA 2008 )Common name(s)
- Artichoke ( McGuffin et al. 2000 )
- Artichoke thistle ( McGuffin et al. 2000 )
- Cardoon ( McGuffin et al. 2000 )
- Cynara ( Unavailable )
- Garden artichoke ( Unavailable )
- Globe artichoke ( Unavailable )
- Scotch thistle ( Unavailable )
Source material
Leaf ( Bradley 2006 , ESCOP 2003 , Blumenthal et al. 2000 )Route Of administration
OralDosage form(s)
Those suited to the allowable route(s) of administration. This monograph is not intended to include food-like dosage forms such as bars, chewing gums or beverages.Use(s) or purpose(s)
Statement(s) to the effect of:
- Used in Herbal Medicine to help relieve digestive upset, such as indigestion. (Bradley 2006, ESCOP 2003, Blumenthal et al. 2000)
- Used in Herbal Medicine to help relieve digestive upset, such as indigestion and help increase bile flow (choleretic). (Unavailable)
- Used in Herbal Medicine to help increase bile flow (choleretic). (Bradley 2006, Mills and Bone 2005, ESCOP 2003, Hoffmann 2003, Blumenthal et al. 2000)
Dose(s)
Adults:
Dose(s):
1 Day per day
Duration of use
No statement is requiredRisk information
Statement(s) to the effect of:
Caution(s) and Warning(s):- Consult a health care practitioner/health care provider/health care professional/doctor/ physician if symptoms persist or worsen. (Barnes et al. 2007, Mills and Bone 2005, ESCOP 2003)
- Consult a health care practitioner/health care provider/health care professional/doctor/ physician prior to use if you are pregnant or have gall stones. (Mills and Bone 2005, ESCOP 2003, Brinker 2001, Blumenthal et al. 2000)
Non-medicinal ingredients
Must be chosen from the current Natural health products ingredients database and must meet the limitations outlined in the database.Specifications
- The finished product specifications must be established in accordance with the requirements described in the NHPD Quality of natural health products guide.
- The medicinal ingredient must comply with the requirements outlined in the Natural health products ingredient database (NHPID).
- The medicinal ingredient may comply with the specifications outlined in the Artichoke Leaf Monograph published in the British Pharmacopoeia.
References cited
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Barnes J, Anderson LA, Philipson JD. 2007. Herbal Medicines, 3rd edition. London (GB): Pharmaceutical Press.
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Blumenthal M, Goldberg A, Brinckmann J, editors. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
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Bradley PR, editor. British Herbal Compendium: A Handbook of Scientific Information on Widely Used Plant Drugs, Volume 2. Bournemouth (UK): British Herbal Medicine Association; 2006.
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Brinker F. 2001. Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications.
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Brinker F. 2010. Online Updates and Additions to Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications. [Updated 2010 July 13; Accessed 2013 January 30]. Available from: http://www.eclecticherb.com/emp/updatesHCDI.html
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ESCOP 2003: ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products, 2nd edition. Exeter (UK): European Scientific Cooperative on Phytotherapy and Thieme; 2003.
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Hoffmann D. 2003. Medical Herbalism: The Science and Practice of Herbal Medicine. Rochester (VT): Healing Arts Press.
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McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. 2000. Herbs of Commerce, 2nd edition. Austin(TX): American Herbal Products Association.
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Mills S, Bone K. 2005. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone.
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USDA 2008: ARS, National Genetic Resources Program. Germplasm Resources Information Network (GRIN). National Germplasm Resources Laboratory, Beltsville (MD). [Accessed 2008-01-21]. Available at http://www.ars-grin.gov/cgi-bin/npgs/html/tax_search.pl
References reviewed
Sinayoko L, Mennecier D, El Jahir Y, Corberand D, Harnois F, Thiolet C, Farret O. [Acute hepatic injury secondary to ingestion of artichoke extracts (Hepanephrol).] Atteinte hépatique aiguë secondaire à la prise d'extraits d'artichaut (Hépanéphrol®). Gastroentérologie clinique et biologique 2007; 31(11):1039-1040 (in French).
Appendix 1: Examples of appropriate dosage preparations and frequencies of use
Dried leaf:
6 g, per day (Blumenthal et al. 2000)
Infusion:
5-10 g dried leaf, per day (ESCOP 2003)
Tincture:
1.5-4 g dried equivalent, per day
(1:2, 3-8 ml) (Mills and Bone 2005)
Dry aqueous extract:
- 4.5-9 g dried equivalent, per day (Bradley 2006)
- 5-10 g dried equivalent, per day (ESCOP 2003)