Natural Health Products Ingredients Database
WHAT'S NEW
What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on February 12, 2021.
- Announcements
- New Ingredients
- Removed Ingredients
- Revised NHPID Names
- Revised Proper and Common Names
- New Roles
- Revised Restrictions
- Other Ingredient Modifications
- Monograph Modifications
- AbLS Modifications
- Controlled Vocabulary Modifications
- Homeopathic Ingredient Modifications
- Previous What's New
ANNOUNCEMENTS
The updates to the NHPID listed below apply to the most recent version of the web-based Product Licence Application (web PLA) form. All new product licence application submissions must use the web PLA form.
New Ingredients
In this update, the following non-homeopathic ingredients were added.
NHPID Name:
Gaultheria Fragrantissima Leaf Oil
Role:
Non-medicinal
Removed Ingredients
In this update, the following non-homeopathic ingredients were removed.
NHPID Name:
Lotaustralin
Role:
No role
NHPID Name:
Alkyl (C12-15) Benzoate
Role:
Non-medicinal
Revised NHPID Names
In this update, the following non-homeopathic ingredients had their NHPID name revised.
Old NHPID Name:
Scaphium lychnophorum
New NHPID Name:
Scaphium affine
Old NHPID Name:
Lactobacillus brevis
New NHPID Name:
Levilactobacillus Brevis
Old NHPID Name:
Lactobacillus buchneri
New NHPID Name:
Lentilactobacillus Buchneri
Old NHPID Name:
Lactobacillus curvatus
New NHPID Name:
Latilactobacillus Curvatus
Old NHPID Name:
Lactobacillus farciminis
New NHPID Name:
Companilactobacillus Farciminis
Old NHPID Name:
Lactobacillus fermentum
New NHPID Name:
Limosilactobacillus Fermentum
Old NHPID Name:
Lactobacillus hilgardii
New NHPID Name:
Lentilactobacillus Hilgardii
Old NHPID Name:
Lactobacillus kefiri
New NHPID Name:
Lentilactobacillus Kefiri
Old NHPID Name:
Lactobacillus mucosae
New NHPID Name:
Limosilactobacillus Mucosae
Old NHPID Name:
Lactobacillus panis
New NHPID Name:
Limosilactobacillus Panis
Old NHPID Name:
Lactobacillus paraplantarum
New NHPID Name:
Lactiplantibacillus Paraplantarum
Old NHPID Name:
Lactobacillus pontis
New NHPID Name:
Limosilactobacillus Pontis
Old NHPID Name:
Lactobacillus salivarius
New NHPID Name:
Ligilactobacillus Salivarius
Old NHPID Name:
Lactobacillus sanfranciscensis
New NHPID Name:
Fructilactobacillus Sanfranciscensis
Old NHPID Name:
Lactobacillus paracasei
New NHPID Name:
Lacticaseibacillus Paracasei
Old NHPID Name:
Lactobacillus coryniformis
New NHPID Name:
Loigolactobacillus Coryniformis
Revised Proper and Common Names
In this update, the following non-homeopathic ingredients had their common or proper names revised.
NHPID Name:
Caulis Dendrobii
New Proper Name(s):
Dendrobium chrysotoxum
NHPID Name:
Fructus Mori
New Common Name(s):
Sang shen zi
NHPID Name:
Semen Juglandis
New Common Name(s):
Hu tao ren
NHPID Name:
Rhizoma Paridis
New Proper Name(s):
Paris polyphylla
NHPID Name:
Rhizoma Paridis
New Common Name(s):
Yunnan chong lou; Hua chong lou; Zao xiu
NHPID Name:
Semen Sterculiae Lychnophorae
New Proper Name(s):
Scaphium affine
NHPID Name:
Lactobacillus brevis
New Proper Name(s):
Levilactobacillus Brevis
NHPID Name:
Lactobacillus brevis
New Common Name(s):
Levilactobacillus Brevis
NHPID Name:
Lactobacillus buchneri
New Proper Name(s):
Lentilactobacillus Buchneri
NHPID Name:
Lactobacillus buchneri
New Common Name(s):
Lentilactobacillus Buchneri
NHPID Name:
Lactobacillus curvatus
New Proper Name(s):
Latilactobacillus Curvatus
NHPID Name:
Lactobacillus curvatus
New Common Name(s):
Latilactobacillus Curvatus
NHPID Name:
Lactobacillus farciminis
New Proper Name(s):
Companilactobacillus Farciminis
NHPID Name:
Lactobacillus farciminis
New Common Name(s):
Companilactobacillus Farciminis
NHPID Name:
Lactobacillus fermentum
New Proper Name(s):
Limosilactobacillus Fermentum
NHPID Name:
Lactobacillus fermentum
New Common Name(s):
Limosilactobacillus Fermentum
NHPID Name:
Lactobacillus hilgardii
New Proper Name(s):
Lentilactobacillus Hilgardii
NHPID Name:
Lactobacillus hilgardii
New Common Name(s):
Lentilactobacillus Hilgardii
NHPID Name:
Lactobacillus kefiri
New Proper Name(s):
Lentilactobacillus Kefiri
NHPID Name:
Lactobacillus kefiri
New Common Name(s):
Lentilactobacillus Kefiri
NHPID Name:
Lactobacillus mucosae
New Proper Name(s):
Limosilactobacillus Mucosae
NHPID Name:
Lactobacillus mucosae
New Common Name(s):
Limosilactobacillus Mucosae
NHPID Name:
Lactobacillus panis
New Proper Name(s):
Limosilactobacillus Panis
NHPID Name:
Lactobacillus panis
New Common Name(s):
Limosilactobacillus Panis
NHPID Name:
Lactobacillus paraplantarum
New Proper Name(s):
Lactiplantibacillus Paraplantarum
NHPID Name:
Lactobacillus paraplantarum
New Common Name(s):
Lactiplantibacillus Paraplantarum
NHPID Name:
Lactobacillus pontis
New Proper Name(s):
Limosilactobacillus Pontis
NHPID Name:
Lactobacillus pontis
New Common Name(s):
Limosilactobacillus Pontis
NHPID Name:
Lactobacillus salivarius
New Proper Name(s):
Ligilactobacillus Salivarius
NHPID Name:
Lactobacillus salivarius
New Common Name(s):
Ligilactobacillus Salivarius
NHPID Name:
Lactobacillus sanfranciscensis
New Proper Name(s):
Fructilactobacillus Sanfranciscensis
NHPID Name:
Lactobacillus sanfranciscensis
New Common Name(s):
Fructilactobacillus Sanfranciscensis
NHPID Name:
Lactobacillus paracasei
New Proper Name(s):
Lacticaseibacillus Paracasei
NHPID Name:
Lactobacillus paracasei
New Common Name(s):
Lacticaseibacillus Paracasei
NHPID Name:
Lactobacillus coryniformis
New Proper Name(s):
Loigolactobacillus Coryniformis
NHPID Name:
Lactobacillus coryniformis
New Common Name(s):
Loigolactobacillus Coryniformis
NHPID Name:
C12-15 Alkyl Benzoate
Removed Proper Name(s):
Alkyl (C12-15) Benzoate
NHPID Name:
C12-15 Alkyl Benzoate
New Proper Name(s):
Benzoic acid, C12-15 alkyl esters
NHPID Name:
Ammonium Benzoate
Removed Proper Name(s):
Ammonium Benzoate
NHPID Name:
Ethylhexyl hydroxystearate benzoate
Removed Proper Name(s):
Ethylhexyl hydroxystearate benzoate
NHPID Name:
Ethylhexyl hydroxystearate benzoate
New Proper Name(s):
Octadecanoic acid, 12-(benzoyloxy)-, 2-ethylhexyl ester
NHPID Name:
Isopentyl benzoate
Removed Proper Name(s):
Isopentyl benzoate
NHPID Name:
Sodium salicylate
Old Role:
Medicinal & Non-medicinal
NHPID Name:
Wintergreen Oil
Non-medicinal Restriction(s) changed:
Revised Detail: Acceptable daily intake up to 0.5 mg/kg bw/day, expressed as methyl salicylate equivalents.
NHPID Name:
Wintergreen Oil
New Restriction Reference added:
WHO_JECFA
NHPID Name:
Wintergreen Oil
Non-medicinal Restriction(s) changed:
Revised Detail: Up to 1%, expressed as methyl salicylate equivalents.
NHPID Name:
Methyl salicylate
Non-medicinal Restriction(s) changed:
Upper Limit: 1.0
.
Units: Percent
NHPID Name:
Sodium salicylate
Non-medicinal Restriction(s) changed:
New Detail: For topical use only, up to 0.5% expressed as salicylic acid equivalents, when formulated to be non-irritating and non-sensitizing.
NHPID Name:
Benzyl alcohol
New Non-medicinal Restriction(s) added:
General
Detail: Must be declared as medicinal ingredient in throat lozenges in daily doses at or above 100 mg/day, and in anorectal products in concentrations at or above 1% w/w.
NHPID Name:
Methyl benzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
New Roles
In this update, the roles of the following non-homeopathic ingredients were changed.
NHPID Name:
Ethyl benzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
Revised Restrictions
In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.
NHPID Name:
Isobutyl benzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
NHPID Name:
Glyceryl tribenzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
NHPID Name:
C12-15 Alkyl Benzoate
Non-medicinal Restriction(s) changed:
New Detail: For topical use only.
NHPID Name:
Ammonium Benzoate
Non-medicinal Restriction(s) changed:
Detail:
For topical use only, up to 0.5%, expressed as benzoic acid equivalents.
NHPID Name:
Ethylhexyl benzoate
Non-medicinal Restriction(s) changed:
Detail:
For topical use only, up to 4%.
NHPID Name:
Ethylhexyl hydroxystearate benzoate
Non-medicinal Restriction(s) changed:
Detail:
For topical use only.
NHPID Name:
Geranyl benzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
NHPID Name:
Glycereth-7 Benzoate
Non-medicinal Restriction(s) changed:
Route Of Administration:
Topical
.
Detail:
For topical use only.
NHPID Name:
Hex-3-enyl benzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
NHPID Name:
Hexyl benzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
NHPID Name:
Passiflora incarnata
New Sub-ingredient(s) added:
Vitexin
NHPID Name:
Gaultheria fragrantissima
New Name Reference added:
GRIN
NHPID Name:
Gaultheria fragrantissima
Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 1 (a plant or a plant material) of the Natural Health Products Regulations.
NHPID Name:
Wintergreen Oil
Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 2 (an extract) of the Natural Health Products Regulations.
NHPID Name:
Wintergreen Oil
New NMI Purpose(s):
Fragrance Ingredient
NHPID Name:
Methyl salicylate
Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.
NHPID Name:
Methyl salicylate
Toxicity Restriction changed:
Revised Detail: Acceptable daily intake up to 0.5 mg/kg bw/day.
NHPID Name:
Rhizoma Paridis
New Source Material(s) added:
Paris polyphylla - Rhizome
NHPID Name:
Semen Sterculiae Lychnophorae
New Source Material(s) added:
Scaphium affine - Seed
NHPID Name:
Semen Sterculiae Lychnophorae
New Taxonomical Synonym(s) added:
Scaphium lychnophorum
NHPID Name:
Scaphium lychnophorum
New Source Material(s) added:
Scaphium affine - Whole plant
NHPID Name:
Lactobacillus brevis
New Source Material(s) added:
Levilactobacillus Brevis - Whole cell
NHPID Name:
Lactobacillus brevis
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus brevis now being considered as a taxonomical synonym of Levilactobacillus brevis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus brevis or Levilactobacillus brevis, following which Lactobacillus brevis will no longer be available for selection and only represented as a taxonomical synonym of Levilactobacillus brevis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus buchneri
New Source Material(s) added:
Lentilactobacillus Buchneri - Whole cell
NHPID Name:
Lactobacillus buchneri
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus buchneri now being considered as a taxonomical synonym of Lentilactobacillus buchneri. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus buchneri or Lentilactobacillus buchneri, following which Lactobacillus buchneri will no longer be available for selection and only represented as a taxonomical synonym of Lentilactobacillus buchneri. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus curvatus
New Source Material(s) added:
Latilactobacillus Curvatus - Whole cell
NHPID Name:
Lactobacillus curvatus
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus curvatus now being considered as a taxonomical synonym of Latilactobacillus curvatus. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus curvatus or Latilactobacillus curvatus, following which Lactobacillus curvatus will no longer be available for selection and only represented as a taxonomical synonym of Latilactobacillus curvatus. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus farciminis
New Source Material(s) added:
Companilactobacillus Farciminis - Whole cell
NHPID Name:
Lactobacillus farciminis
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus farciminis now being considered as a taxonomical synonym of Companilactobacillus farciminis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus farciminis or Companilactobacillus farciminis, following which Lactobacillus farciminis will no longer be available for selection and only represented as a taxonomical synonym of Companilactobacillus farciminis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus fermentum
New Source Material(s) added:
Limosilactobacillus Fermentum - Whole cell
Other Ingredient Modifications
In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.
NHPID Name:
Lactobacillus fermentum
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus fermentum now being considered as a taxonomical synonym of Limosilactobacillus fermentum. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus fermentum or Limosilactobacillus fermentum, following which Lactobacillus fermentum will no longer be available for selection and only represented as a taxonomical synonym of Limosilactobacillus fermentum. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus hilgardii
New Source Material(s) added:
Lentilactobacillus Hilgardii - Whole cell
NHPID Name:
Lactobacillus hilgardii
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus hilgardii now being considered as a taxonomical synonym of Lentilactobacillus hilgardii. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus hilgardii or Lentilactobacillus hilgardii, following which Lactobacillus hilgardii will no longer be available for selection and only represented as a taxonomical synonym of Lentilactobacillus hilgardii. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus kefiri
New Source Material(s) added:
Lentilactobacillus Kefiri - Whole cell
NHPID Name:
Lactobacillus kefiri
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus kefiri now being considered as a taxonomical synonym of Lentilactobacillus kefiri. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus kefiri or Lentilactobacillus kefiri, following which Lactobacillus kefiri will no longer be available for selection and only represented as a taxonomical synonym of Lentilactobacillus kefiri. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
.
.
NHPID Name:
Lactobacillus mucosae
New Source Material(s) added:
Limosilactobacillus Mucosae - Whole cell
NHPID Name:
Lactobacillus mucosae
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus mucosae now being considered as a taxonomical synonym of Limosilactobacillus mucosae. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus mucosae or Limosilactobacillus mucosae, following which Lactobacillus mucosae will no longer be available for selection and only represented as a taxonomical synonym of Limosilactobacillus mucosae. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus panis
New Source Material(s) added:
Limosilactobacillus Panis - Whole cell
NHPID Name:
Lactobacillus panis
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus panis now being considered as a taxonomical synonym of Limosilactobacillus panis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus panis or Limosilactobacillus panis, following which Lactobacillus panis will no longer be available for selection and only represented as a taxonomical synonym of Limosilactobacillus panis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus paraplantarum
New Source Material(s) added:
Lactiplantibacillus Paraplantarum - Whole cell
NHPID Name:
Lactobacillus paraplantarum
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus paraplantarum now being considered as a taxonomical synonym of Lactiplantibacillus paraplantarum. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus paraplantarum or Lactiplantibacillus paraplantarum, following which Lactobacillus paraplantarum will no longer be available for selection and only represented as a taxonomical synonym of Lactiplantibacillus paraplantarum. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus pontis
New Source Material(s) added:
Limosilactobacillus Pontis - Whole cell
NHPID Name:
Lactobacillus pontis
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus pontis now being considered as a taxonomical synonym of Limosilactobacillus pontis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus pontis or Limosilactobacillus pontis, following which Lactobacillus pontis will no longer be available for selection and only represented as a taxonomical synonym of Limosilactobacillus pontis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus salivarius
New Source Material(s) added:
Ligilactobacillus Salivarius - Whole cell
NHPID Name:
Lactobacillus salivarius
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus salivarius now being considered as a taxonomical synonym of Ligilactobacillus salivarius. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus salivarius or Ligilactobacillus salivarius, following which Lactobacillus salivarius will no longer be available for selection and only represented as a taxonomical synonym of Ligilactobacillus salivarius. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus sanfranciscensis
New Source Material(s) added:
Fructilactobacillus Sanfranciscensis - Whole cell
NHPID Name:
Lactobacillus sanfranciscensis
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus sanfranciscensis now being considered as a taxonomical synonym of Fructilactobacillus sanfranciscensis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus sanfranciscensis or Fructilactobacillus sanfranciscensis, following which Lactobacillus sanfranciscensis will no longer be available for selection and only represented as a taxonomical synonym of Fructilactobacillus sanfranciscensis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus paracasei
New Source Material(s) added:
Lacticaseibacillus Paracasei - Whole cell
NHPID Name:
Lactobacillus paracasei
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus paracasei now being considered as a taxonomical synonym of Lacticaseibacillus paracasei. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus paracasei or Lacticaseibacillus paracasei, following which Lactobacillus paracasei will no longer be available for selection and only represented as a taxonomical synonym of Lacticaseibacillus paracasei. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Lactobacillus coryniformis
New Source Material(s) added:
Loigolactobacillus Coryniformis - Whole cell
NHPID Name:
Lactobacillus coryniformis
New Additional Details added :
Based on Zheng et al. (2020), the Lactobacillus genus has been reclassified into 25 genera, resulting in Lactobacillus coryniformis now being considered as a taxonomical synonym of Loigolactobacillus coryniformis. The Natural and Non-prescription Health Products Directorate is therefore in the process of transitioning these names in accordance with this new taxonomic status, including in its Probiotics monograph. Until such time that the revised monograph is published, applicants can select and represent their medicinal ingredient as either Lactobacillus coryniformis or Loigolactobacillus coryniformis, following which Lactobacillus coryniformis will no longer be available for selection and only represented as a taxonomical synonym of Loigolactobacillus coryniformis. Product licence holders are encouraged to transition their labelling and therefore their licence(s) accordingly.
NHPID Name:
Sodium salicylate
Modification:
Removed Schedule 1: Isolate
NHPID Name:
Benzyl alcohol
Toxicity Restriction changed:
Revised Detail: Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
NHPID Name:
Methyl benzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Ethyl benzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Isobutyl benzoate
New Source Material(s) added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Glyceryl tribenzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Dipropylene glycol dibenzoate
Removed NMI purpose(s):
Plasticizer
NHPID Name:
Ethylhexyl hydroxystearate benzoate
New CAS Registry Number(s) added:
199277-69-5
NHPID Name:
Geranyl benzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Hex-3-enyl benzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Hexyl benzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Poloxamer 105 Benzoate
New NMI Purpose(s):
Emulsifying Agent; Surfactant - Solubilizing Agent
NHPID Name:
Isopentyl benzoate
New Proper Name(s):
Benzoic acid, isopentyl ester
NHPID Name:
Isopentyl benzoate
Removed Common Name(s):
1-Butanol, 3-methyl-, benzoate; 3-methylbutyl benzoate; Benzoic acid, isopentyl ester; Isopentyl alcohol, benzoate
NHPID Name:
Isopentyl benzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Isopentyl benzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
NHPID Name:
Isopropyl benzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Isopropyl benzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
NHPID Name:
Isostearyl benzoate
Non-medicinal Restriction(s) changed:
Route Of Administration:
Topical
.
Detail:
For topical use only, up to 1%
NHPID Name:
Laureth-2 benzoate
Non-medicinal Restriction(s) changed:
Route Of Administration:
Topical
.
Detail:
For topical use only.
NHPID Name:
Lauryl/Myristyl Benzoate
Non-medicinal Restriction(s) changed:
Detail:
For topical use only.
NHPID Name:
Linalyl benzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Linalyl benzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
NHPID Name:
Phenethyl Benzoate
Non-medicinal Restriction(s) changed:
Detail:
For topical use only.
NHPID Name:
Poloxamer 105 Benzoate
Removed NMI purpose(s):
Emulsifying Agent; Lubricant; Solubilizing Agent; Suspending Agent - Nonsurfactant; Wetting Agent
NHPID Name:
Poloxamer 105 Benzoate
Non-medicinal Restriction(s) changed:
Route Of Administration:
Topical
.
Detail:
For topical use only.
NHPID Name:
Benzoate de PPG-15 stéaryl éther
Non-medicinal Restriction(s) changed:
Detail:
For topical use only.
NHPID Name:
Propyl Benzoate
Removed Proper Name(s):
Propyl Benzoate
NHPID Name:
Propyl Benzoate
New Proper Name(s):
Benzoic acid, propyl ester
NHPID Name:
Propyl Benzoate
Removed Common Name(s):
Benzoic acid, propyl ester; n-propyl benzenecarboxylate; Propyl phenyl methanoate
NHPID Name:
Propyl Benzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
NHPID Name:
Propyl Benzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only. / Pour usage oral seulement.
NHPID Name:
Propylene glycol dibenzoate
New Toxicity restriction added:
Toxicity Restriction
Upper Limit:
5.0
.
Units:
Milligrams/kilogram body weight/day
.
Detail:
Acceptable daily intake up to 5 mg/kg bw/day, expressed as benzoic acid equivalents.
.
Reference:
GOC_2019_ASSESS_BENZ
.
.
NHPID Name:
Propylene glycol dibenzoate
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
• Revised Detail: For oral use only.
NHPID Name:
Benzophenone
Removed Proper Name(s):
Benzophenone
NHPID Name:
Benzophenone
New Proper Name(s):
Diphenylmethanone
NHPID Name:
Benzophenone
Removed Common Name(s):
Methanone, diphenyl-
NHPID Name:
Benzophenone
Non-medicinal Restriction(s) changed:
Removed Allowed Purposes: Flavour Enhancer
Revised Detail: For oral use only, up to 3.27 ppm.
Monograph Modifications
In this update, the following single ingredient or product monographs were added or modified.
No Changes.
AbLS Modifications
In this update, the following abbreviated labelling standards were added or modified.
No Changes.
Controlled Vocabulary Modifications
In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.
No Changes.
Homeopathic Ingredient Modifications
In this update, the following homeopathic ingredients were added or modified.
No Changes.
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