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Drugs and Health Products

Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on January 10, 2017.

ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest version of the e-PLA, namely version 2.3.1, which is available for downloading from e-PLA 2.3.1


New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Ethylhexyl hydroxystearate benzoate

Role:
Non-medicinal


NHPID Name:
Gamma-glutamyl phenylalanine

Role:
No role


NHPID Name:
Potassium glutarate

Role:
No role


NHPID Name:
Manganese(II) fumarate

Role:
No role


NHPID Name:
Potassium succinate

Role:
No role


NHPID Name:
Manganese (II) succinate

Role:
No role


NHPID Name:
Carica Papaya (Papaya) Leaf extract

Role:
Non-medicinal


NHPID Name:
Strongylocentrotus droebachiensis

Role:
Medicinal


NHPID Name:
Pseudowintera colorata

Role:
Medicinal


NHPID Name:
Ampelopsis grossedentata

Role:
Medicinal


Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

No Changes.


Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

Old NHPID Name:
Methyl furoate

New NHPID Name:
Methyl 2-furoate


Old NHPID Name:
Pentyl 2-furoate

New NHPID Name:
Amyl 2-furoate


Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Benzophenone

Removed Common Name(s):
Alpha-Oxodiphenylmethane; Benzoylbenzene; Diphenyl Ketone; diphenylmethanone; Phenyl ketone


NHPID Name:
Benzophenone

New Common Name(s):
Benzophenone


NHPID Name:
Furfural

Removed Proper Name(s):
Furfural


NHPID Name:
Furfural

New Proper Name(s):
2-Furancarboxaldehyde


NHPID Name:
Furfural

Removed Common Name(s):
2-Formylfuran; 2-furaldehyde; 2-Furancarboxaldehyde; 2-Furylcarboxaldehyde; Fural; Furaldehyde; furan-2-carbaldehyde; Furfuraldehyde; furfurol; pyromucic aldehyde


NHPID Name:
5-Methylfurfural

Removed Proper Name(s):
5-Methylfurfural


NHPID Name:
5-Methylfurfural

New Proper Name(s):
5-Methyl-2-furancarboxaldehyde


NHPID Name:
5-Methylfurfural

Removed Common Name(s):
2-Furaldehyde, 5-methyl-; 2-Furancarboxaldehyde, 5-methyl-; 5-Methyl-2-furaldehyde; 5-Methyl-2-furfural; 5-methylfuran-2-carbaldehyde; 5-Methyl furfural


NHPID Name:
5-Methylfurfural

New Common Name(s):
5-Methylfurfural


NHPID Name:
2-Phenyl-3-carbethoxyfuran

Removed Proper Name(s):
3-Furancarboxylic acid, 2-phenyl-, ethyl ester; Ethyl 2-Phenyl-3-furoate


NHPID Name:
2-Phenyl-3-carbethoxyfuran

New Common Name(s):
2-Phenyl-3-carbethoxyfuran


NHPID Name:
Methyl 2-furoate

Removed Common Name(s):
Methyl furoate


NHPID Name:
Methyl 2-furoate

New Common Name(s):
Methyl 2-furoate


NHPID Name:
Methyl 2-furoate

Removed Proper Name(s):
Furancarboxylic acid, methyl ester


NHPID Name:
Methyl 2-furoate

New Proper Name(s):
2-Furancarboxylic acid, methyl ester


NHPID Name:
Propyl 2-furoate

Removed Common Name(s):
2-Furancarboxylic acid, propyl ester; 2-Furoic acid, propyl ester; n-propyl pyromucate; propyl furan-2-carboxylate


NHPID Name:
Propyl 2-furoate

New Common Name(s):
Propyl 2-furoate


NHPID Name:
Propyl 2-furoate

Removed Proper Name(s):
Propyl 2-Furoate


NHPID Name:
Propyl 2-furoate

New Proper Name(s):
2-Furancarboxylic acid, propyl ester


NHPID Name:
Amyl 2-furoate

Removed Common Name(s):
2-furoic acid, pentyl ester; Amyl furan-2-carboxylate; Furancarboxylic acid, pentyl ester; Pentyl furan-2-carboxylate


NHPID Name:
Amyl 2-furoate

Removed Proper Name(s):
Pentyl 2-furoate


NHPID Name:
Amyl 2-furoate

New Proper Name(s):
Furancarboxylic acid, pentyl ester


NHPID Name:
Sodium PCA

New Proper Name(s):
5-Oxo-DL-Proline, Monosodium Salt


New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
Cetyl myristate

Old Role:
No role

New Role:
Non-medicinal


NHPID Name:
Ethyl lactate

Old Role:
Non-medicinal

New Role:
Medicinal & Non-medicinal


NHPID Name:
Sanguis Cervi

Old Role:
Medicinal

New Role:
Non-NHP


NHPID Name:
Clay

Old Role:
Medicinal

New Role:
Medicinal & Non-medicinal


Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Benzophenone-2

New Non-medicinal Restriction(s) added:
For topical use only, up to 0.4%.


NHPID Name:
Benzophenone-4

New Non-medicinal Restriction(s) added:
For topical use only, up to 0.1%, if not contributing to the product`s claim(s).


NHPID Name:
Furfural

Non-medicinal Restriction(s) changed:
Acceptable daily intake up to 0.5 mg/kg bw/day.


NHPID Name:
Cinnamomum Zeylanicum Bark Oil

New Non-medicinal Restriction(s) added:
Maximum concentration permitted for topical uses Fragrance ingredient and Masking agent: 0.07% (IFRA2009; Tisserand and Young 2014).


NHPID Name:
Sanguis Cervi

Medicinal Restriction(s) removed:
Deer blood is sourced from an animal susceptible to Transmissible Spongiform Encephalopathy (TSE). In order to minimize the risk of TSEs, please ensure the following procedures are in place: Source animals are fit for human consumption; materials can be traced back to source (herd or animal); avoidance of cross contamination with high-infectivity tissues during sourcing; and manufacturing procedures that are known to reduce infectivity (if any) are implemented (e.g. procedures that are in accordance with Chapter 5.2.8 of the European Pharmacopoeia).


NHPID Name:
Edetic acid

Non-medicinal Restriction(s) changed:
The concentration of nitrilotriacetic acid in EDTA should not exceed 0.3%.


NHPID Name:
Edetate calcium disodium

Non-medicinal Restriction(s) changed:
Up to 25 mg/kg body weight per day. Not acceptable in products with a disinfectant claim above 0.05%. The concentration of nitrilotriacetic acid in Edetate calcium disodium should not exceed 0.1%.


NHPID Name:
Disodium EDTA

Non-medicinal Restriction(s) changed:
Up to 25 mg/kg body weight per day, expressed as Edetate calcium disodium. The concentration of nitrilotriacetic acid in Disodium edetate should not exceed 0.1%.


Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Beta vulgaris

New Sub-ingredient(s) added:
Potassium


NHPID Name:
Benzophenone

New Toxicity restriction added:
Tolerable daily intake up to 0.03 mg/kg bw/day.


NHPID Name:
5-Methylfurfural

New Toxicity restriction added:
Acceptable daily intake up to 0.14 mg/kg bw/day, expressed as 5-hydroxymethylfurfural equivalents.


NHPID Name:
2-Benzofurancarboxaldehyde

New Toxicity restriction added:
Acceptable daily intake up to 0.25 mg/kg bw/day.


NHPID Name:
2-Phenyl-3-carbethoxyfuran

New Toxicity restriction added:
Acceptable daily intake up to 0.13 mg/kg bw/day.


NHPID Name:
Furfuryl alcohol

Toxicity Restriction changed:
Acceptable daily intake up to 0.5 mg/kg bw/day, expressed in furfural equivalents.


NHPID Name:
Furfuryl acetate

Toxicity Restriction changed:
Acceptable daily intake up to 0.5 mg/kg bw/day, expressed in furfural equivalents.


NHPID Name:
Furfuryl propionate

New Toxicity restriction added:
Acceptable daily intake up to 0.5 mg/kg bw/day, expressed in furfural equivalents.


NHPID Name:
Furfuryl valerate

New Toxicity restriction added:
Acceptable daily intake up to 0.5 mg/kg bw/day, expressed in furfural equivalents.


NHPID Name:
Furfuryl octanoate

New Toxicity restriction added:
Acceptable daily intake up to 0.5 mg/kg bw/day, expressed in furfural equivalents.


NHPID Name:
Furfuryl isovalerate

Toxicity Restriction changed:
Acceptable daily intake up to 0.5 mg/kg bw/day, expressed in furfural equivalents.


NHPID Name:
Methyl 2-furoate

Toxicity Restriction changed:
Acceptable daily intake up to 0.5 mg/kg bw/day, expressed in furfural equivalents.


NHPID Name:
Propyl 2-furoate

Toxicity Restriction changed:
Acceptable daily intake up to 0.5 mg/kg bw/day, expressed in furfural equivalents.


NHPID Name:
Amyl 2-furoate

Toxicity Restriction changed:
Acceptable daily intake up to 0.5 mg/kg bw/day, expressed in furfural equivalents.


NHPID Name:
Hexyl 2-furoate

Toxicity Restriction changed:
Acceptable daily intake up to 0.5 mg/kg bw/day, expressed in furfural equivalents.


NHPID Name:
Octyl 2-furoate

Toxicity Restriction changed:
Flavouring agent only Acceptable daily intake up to 0.5mg/kg body weight daily(JECFA, 2000)


NHPID Name:
Vigna unguiculata subsp. Cylindrica

New Sub-ingredient(s) added:
Gamma-glutamyl phenylalanine


NHPID Name:
Piper betle

New Sub-ingredient(s) added:
Polyphenols


NHPID Name:
Manganese

New Source Material(s) added:
Manganese(II) fumarate


NHPID Name:
Shark cartilage

New Sub-ingredient(s) added:
Glucosamine sulfate


NHPID Name:
DL-Lactic acid

New Source Material(s) added:
Ethyl lactate


NHPID Name:
Mustard oil

New Additional Details added :
The presence of the ingredient "allyl isothiocyanate", the main constituent of mustard oil, as a prohibited substance on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient cannot be used as a non-medicinal ingredient in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/index-eng.php


NHPID Name:
Allyl isothiocyanate

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient cannot be used as a non-medicinal ingredient in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/index-eng.php


NHPID Name:
Strongylocentrotus droebachiensis

New Sub-ingredient(s) added:
Fucoxanthinol


NHPID Name:
Strongylocentrotus droebachiensis

New Source Material(s) added:
Intestine


NHPID Name:
Strongylocentrotus droebachiensis

New Sub-ingredient(s) added:
Fucoxanthin


NHPID Name:
Sceletium tortuosum

New Source Material(s) added:
Leaf and Stem


NHPID Name:
Sceletium tortuosum

New Sub-ingredient(s) added:
Total alkaloids


NHPID Name:
Selenium aspartate

Additional Details removed:
The presence of this ingredient without conditions on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient cannot be used in topical natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/person/cosmet/info-ind-prof/_hot-list-critique/prohibited-eng.php


NHPID Name:
Sodium borate

Additional Details changed:
This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in topical natural health products, unless additional evidence for safety is submitted. Included in the Hotlist for this ingredient under "Restrictions" are (1) the risk statement "Do not use on broken or abraded skin" (required on the PLA (Product Licence Application) form and label), (2) a subpopulation of "children over 3 years of age" and (3) a maximum concentration of 5%.


NHPID Name:
Boric Acid

Additional Details changed:
This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in topical natural health products, unless additional evidence for safety is submitted. Included in the Hotlist for this ingredient under "Restrictions" are (1) the risk statement "Do not use on broken or abraded skin" (required on the PLA (Product Licence Application) form and label), (2) a subpopulation of "children over 3 years of age" and (3) a maximum concentration of 5%.


NHPID Name:
Potassium borate

Additional Details changed:
This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in topical natural health products, unless additional evidence for safety is submitted. Included in the Hotlist for this ingredient under "Restrictions" are (1) the risk statement "Do not use on broken or abraded skin" (required on the PLA (Product Licence Application) form and label), (2) a subpopulation of "children over 3 years of age" and (3) a maximum concentration of 5%.


NHPID Name:
Pullulan

New NMI Purpose(s):
Encapsulating Agent


NHPID Name:
Sodium caprylate

New Sub-ingredient(s) added:
Octanoic acid


NHPID Name:
Clay

New NMI Purpose(s):
Viscosity Increasing Agent


NHPID Name:
Mustard oil

New Additional Details added :
The presence of the ingredient "allyl isothiocyanate", the main constituent of mustard oil, as a prohibited substance on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient cannot be used as a non-medicinal ingredient in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/index-eng.php


NHPID Name:
Allyl isothiocyanate

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient cannot be used as a non-medicinal ingredient in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/index-eng.php


Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

No Changes.


AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.


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