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Drugs and Health Products

Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on November 29, 2016.

ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest version of the e-PLA, namely version 2.3.1, which is available for downloading from e-PLA 2.3.1


New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Polyquaternium-22

Role:
Non-medicinal


NHPID Name:
Sour apple flavour

Role:
Non-medicinal


NHPID Name:
Chocolate sandwich cookie flavour

Role:
Non-medicinal


NHPID Name:
Whipped cream flavour

Role:
Non-medicinal


NHPID Name:
Cinnamon bun flavour

Role:
Non-medicinal


NHPID Name:
Cookie dough flavour

Role:
Non-medicinal


NHPID Name:
Sweet dough flavour

Role:
Non-medicinal


NHPID Name:
Nephelium Lappaceum Peel Extract

Role:
Non-medicinal


NHPID Name:
PPG-3 Isostearyl Methyl Ether

Role:
Non-medicinal


NHPID Name:
Calebin-A

Role:
Medicinal


NHPID Name:
Marrubium Vulgare Extract

Role:
Non-medicinal


NHPID Name:
Silybum Marianum Fruit Extract

Role:
Non-medicinal


NHPID Name:
Flueggea suffruticosa

Role:
Medicinal


NHPID Name:
Bambusa Arundinacea Stem Extract

Role:
Non-medicinal


NHPID Name:
Nonoxynol-30

Role:
Non-medicinal


NHPID Name:
Ethylhexyl Acrylate

Role:
Non-medicinal


NHPID Name:
Diethylenetriaminepenta(methylenephosphonic) acid

Role:
Non-medicinal


NHPID Name:
Herba Strigae

Role:
Medicinal


NHPID Name:
Coriander seed essential oil

Role:
Medicinal


NHPID Name:
Mono- and diglycerides of fatty acids

Role:
Non-medicinal


NHPID Name:
Houttuynia Cordata Extract

Role:
Non-medicinal


NHPID Name:
Primula veris root extract

Role:
Medicinal


NHPID Name:
Bacillus clausii

Role:
Medicinal


NHPID Name:
Bacillus indicus

Role:
Medicinal


Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

No Changes.


Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

Old NHPID Name:
Methyl sulfide

New NHPID Name:
Dimethyl sulfide


Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Ceramide 2

New Common Name(s):
Ceramide NG, Ceramide NS


NHPID Name:
Dimethyl sulfide

New Proper Name(s):
1,1'-Thiobismethane


NHPID Name:
Methyl sulfide

Removed Proper Name(s):
Methane, 1,1'-thiobis-


NHPID Name:
Dimethyl sulfide

New Common Name(s):
Dimethyl sulfide


NHPID Name:
Dibenzyl disulfide

Removed Proper Name(s):
Dibenzyl disulfide


NHPID Name:
Dibenzyl disulfide

New Proper Name(s):
Bis(phenylmethyl) disulfide


NHPID Name:
Dibenzyl disulfide

Removed Common Name(s):
1,4-Diphenyl-1,2,3-dithiobutane; 1,4-Diphenyl-2,3-dithiobutane; 4,4'-Biphenyldiglyoxal disodium bisulfite; alpha-(benzyldithio)toluene; alpha-Benzyldithio toluene; BDS; benzyldisulfanylmethylbenzene; Bis(phenylmethyl) disulfide; Bis(phenylmethyl) disulfide; di(phenylmethyl)disulfide; Disulfide, bis(phenylmethyl); Disulfide, dibenzyl


NHPID Name:
p-Menth-1-ene-8-thiol

New Common Name(s):
Grapefruit mercaptan


NHPID Name:
PEG/PPG-17/6 Copolymer

New Common Name(s):
PEG/PPG-17/6 Copolymer


NHPID Name:
Stannous fluoride

New Proper Name(s):
Stannous fluoride


NHPID Name:
Laminaria digitat

Removed Common Name(s):
Brown Seaweed, Anguiller


NHPID Name:
Macrocystis pyrifera

Removed Common Name(s):
Brown Seaweed; Brown algae


NHPID Name:
Lutein

New Common Name(s):
Xanthophyll


New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
Aluminum chloride hexahydrate

Old Role:
No role

New Role:
Medicinal


Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Dibenzyl disulfide

Medicinal Restriction(s) Changed :
Flavouring agent only, up to 0.0012 mg/kg bw/day.


NHPID Name:
p-Menth-1-ene-8-thiol

Non-medicinal Restriction(s) changed:
Flavouring agent only, up to 0.00056 mg/kg bw/day.


NHPID Name:
Aluminum sesquichlorohydrex PEG

Non-medicinal Restriction(s) changed:
For topical use only.


NHPID Name:
Aluminum sesquichlorohydrex PG

Non-medicinal Restriction(s) changed:
For topical use only.


NHPID Name:
Aluminum zirconium octachlorohydrate, Aluminum zirconium octachlorohydrex glycine, Aluminum zirconium pentachlorohydrate, Aluminum zirconium pentachlorohydrex, Aluminum zirconium tetrachlorohydrate, Aluminium zirconium tetrachlorohydrex glycine, Aluminum zirconium tetrachlorohydrex PEG, Aluminum zirconium tetrachlorohydrex PG, Aluminum zirconium trichlorohydrate, Aluminum zirconium trichlorohydrex glycine

Non-medicinal Restriction(s) changed:
For topical use only.


NHPID Name:
Artemisia annua, Artemisia anomala, Artemisia capillaris, Artemisia dracunculus, Artemisia lactiflora, Artemisia scoparia, Artemisia vulgaris, Folium Artemisiae Argyi, Tarragon Essential Oil

New Medicinal Restriction(s) added :
Artemisia species contain thujone. For adults, the upper limit for total daily intake of thujone from health products is 6 mg. Product licence applications for oral products should include a copy of a certificate of analysis or any other equivalent document demonstrating that the thujone content of a daily dose of the product is acceptable. Because thujone content of the herbal materials can vary, the thujone content should be determined for each batch during production of the product.


NHPID Name:
Aluminum chlorohydrate

New Non-medicinal Restriction(s) added:
For topical use only.


NHPID Name:
Aluminum chlorohydrex PEG

New Non-medicinal Restriction(s) added:
For topical use only.


NHPID Name:
Aluminum chlorohydrex propylene glycol

Non-medicinal Restriction(s) changed:
For topical use only.


NHPID Name:
Aluminum dichlorohydrate

New Non-medicinal Restriction(s) added:
For topical use only.


NHPID Name:
Aluminum dichlorohydrex PEG

Non-medicinal Restriction(s) changed:
For topical use only.


NHPID Name:
Aluminum dichlorohydrex PG

Non-medicinal Restriction(s) changed:
For topical use only.


NHPID Name:
Aluminum sesquichlorohydrate

Non-medicinal Restriction(s) changed:
For topical use only.


NHPID Name:
Tagetes extract

Non-medicinal Restriction(s) changed:
Topical use only for the purposes Colour Additive and Skin-Conditioning Agent - Occlusive, as in the International Cosmetic Ingredient Dictionary.


Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Disodium ethylene dicocamide PEG-15 disulfate

New NMI Purpose(s):
Surfactant - Cleansing Agent


NHPID Name:
Trilinolenin

New NMI Purpose(s):
Emollient


NHPID Name:
Solanum lycopersicum

New Sub-ingredient(s) added:
Phytosterols, Phytoene, Phytofluene, Vitamin E


NHPID Name:
Sodium hydroxide

New NMI Purpose(s):
Buffering Agent


NHPID Name:
Laminaria Digitata Extract

New NMI Purpose(s):
Skin Protectant


NHPID Name:
Potassium cetyl phosphate

New NMI Purpose(s):
Surfactant


NHPID Name:
Terminalia bellirica

New Sub-ingredient(s) added:
Chebulagic acid, Chebulinic acid, Ellagic acid, Gallic acid, Tannins


NHPID Name:
Copaifera officinalis

New Source Material(s) added:
Copaifera officinalis - Trunk wood oleoresin


NHPID Name:
Copaifera officinalis

Source Material(s) removed:
Copaifera officinalis - Stem bark resin


NHPID Name:
Methoxydiglycol

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient cannot be used in topical natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php


NHPID Name:
Aluminum sesquichlorohydrex PEG

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum sesquichlorohydrex PEG

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Aluminum sesquichlorohydrex PG

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum sesquichlorohydrex PG

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Aluminum zirconium octachlorohydrate, Aluminum zirconium octachlorohydrex glycine, Aluminum zirconium pentachlorohydrate, Aluminum zirconium pentachlorohydrex, Aluminum zirconium tetrachlorohydrate, Aluminium zirconium tetrachlorohydrex glycine, Aluminum zirconium tetrachlorohydrex PEG, Aluminum zirconium tetrachlorohydrex PG, Aluminum zirconium trichlorohydrate, Aluminum zirconium trichlorohydrex glycine

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum zirconium octachlorohydrate, Aluminum zirconium octachlorohydrex glycine, Aluminum zirconium pentachlorohydrate, Aluminum zirconium pentachlorohydrex, Aluminum zirconium tetrachlorohydrate, Aluminium zirconium tetrachlorohydrex glycine, Aluminum zirconium tetrachlorohydrex PEG, Aluminum zirconium tetrachlorohydrex PG, Aluminum zirconium trichlorohydrate, Aluminum zirconium trichlorohydrex glycine

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Fragaria vesca, Rubus idaeus, Vaccinium myrtillus

New Sub-ingredient(s) added:
Polyphenols


NHPID Name:
Tagetes extract

New NMI Purpose(s):
Skin-Conditioning Agent - Occlusive


NHPID Name:
Hydrolyzed collagen

New Source Material(s) added:
Bovine ( Parts: Bovine skin/hide split )


NHPID Name:
Methyl alcohol

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Panax Ginseng Root Extract

New NMI Purpose(s):
Flavour Enhancer - Natural


NHPID Name:
Glycerol

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in topical natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php


NHPID Name:
Benzalkonium chloride

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included as a non-medicinal ingredient in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php. RestrictionĚ Maximum concentration permitted 0.1%, except for use in rinse-off hair care products.


NHPID Name:
Aluminum chloride hexahydrate

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum chlorohydrate

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum chlorohydrate

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Aluminum chlorohydrex PEG

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum chlorohydrex PEG

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Aluminum chlorohydrex propylene glycol

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum chlorohydrex propylene glycol

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Aluminum dichlorohydrate

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum dichlorohydrate

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Aluminum dichlorohydrex PEG

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum dichlorohydrex PEG

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Aluminum dichlorohydrex PG

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum dichlorohydrex PG

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Aluminum sesquichlorohydrate

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Aluminum sesquichlorohydrate

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Oryza sativa

New Sub-ingredient(s) added:
Sucrose


Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

No Changes.


AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.


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