Natural Health Products Ingredients Database
WHAT'S NEW
What's New is a listing of modifications to the NHPID since the
last update. This page was most recently revised on November 15, 2016.
ANNOUNCEMENTS
The updates to the NHPID listed below apply to the most recent version of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest version of the e-PLA, namely version 2.3.1, which is available for downloading from e-PLA 2.3.1
New Ingredients
In this update, the following non-homeopathic ingredients were added.
NHPID Name:
Opuntia Ficus-Indica Fruit Extract
Role:
Non-medicinal
NHPID Name:
Palmitoyl Hexapeptide-14
Role:
Non-medicinal
NHPID Name:
Diglucosyl Gallic Acid
Role:
Non-medicinal
NHPID Name:
Diethyl sebacate
Role:
Decanedioic acid, diethyl ester
NHPID Name:
Rhodiola Rosea Root Extract
Role:
Non-medicinal
NHPID Name:
Crotonaldehyde
Role:
Non-medicinal
NHPID Name:
Phosphoethanolamine
Role:
Medicinal
NHPID Name:
PEG-32 Stearate
Role:
Non-medicinal
NHPID Name:
Labisia pumila
Role:
Medicinal
Removed Ingredients
In this update, the following non-homeopathic ingredients were removed.
No Changes.
Revised NHPID Names
In this update, the following non-homeopathic ingredients had their NHPID name revised.
Old NHPID Name:
Ethyl sebacate
New NHPID Name:
Diethyl sebacate
Revised Proper and Common Names
In this update, the following non-homeopathic ingredients had their common or proper names revised.
NHPID Name:
Carrot Seed Oil
New Common Name(s):
Carrot Seed Essential Oil
NHPID Name:
Carrot Seed Oil
New Common Name(s):
Daucus Carota Sativa (Carrot) Seed Oil
NHPID Name:
Ophiocordyceps sinensis
New Common Name(s):
Dong chong xia cao; Cordyceps; Chinese Caterpillar Fungus; Cordyceps sinensis
New Roles
In this update, the roles of the following non-homeopathic ingredients were changed.
NHPID Name:
Morpholine
Old Role:
Non-medicinal
New Role:
No role
Revised Restrictions
In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.
NHPID Name:
Diethylene glycol
Non-medicinal Restriction(s) changed:
For use in topical rinse-off products only. Not permitted in oral or leave-on products.
NHPID Name:
Herba Artemisiae Annuae, Herba Artemisiae Anomalae, Herba Artemisiae Scopariae
New Medicinal Restriction(s) added :
Artemisia species contain thujone. For adults, the upper limit for total daily intake of thujone from health products is 6 mg. Product licence applications for oral products should include a copy of a certificate of analysis or any other equivalent document demonstrating that the thujone content of a daily dose of the product is acceptable. Because thujone content of the herbal materials can vary, the thujone content should be determined for each batch during production of the product.
Other Ingredient Modifications
In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.
NHPID Name:
Methoxyisopropanol
New Toxicity restriction added:
Maximum of 0.5% 2-methoxypropanol (CAS Registry Number: 1589-47-5).
NHPID Name:
Methoxyisopropanol
New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included as an ingredient in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.
NHPID Name:
Isobutane
New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included as an ingredient in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.
NHPID Name:
Inula Helenium Extract
New Additional Details added :
The presence of the ingredient "Inula helenium oil" as a prohibited substance on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. Inula helenium oil cannot be used in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/person/cosmet/info-ind-prof/_hot-list-critique/prohibited-eng.php
NHPID Name:
Placental protein
New Additional Details added :
The presence of the ingredient "Human placental protein" on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included as an ingredient in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.
NHPID Name:
Morpholine
New Additional Details added :
The presence of this ingredient without conditions on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient cannot be used in topical natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/person/cosmet/info-ind-prof/_hot-list-critique/prohibited-eng.php.
NHPID Name:
Gold
New Additional Details added :
The presence of the ingredient "Gold salts" as a prohibited substance on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. Gold salts cannot be used in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php
NHPID Name:
Diethylene glycol
New Additional Details added :
The presence of the ingredient "Gold salts" as a prohibited substance on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. Gold salts cannot be used in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php
NHPID Name:
Aluminum chloride
New Additional Details added :
The presence of the ingredient "Gold salts" as a prohibited substance on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. Gold salts cannot be used in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php
NHPID Name:
Aluminum chloride
Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.
NHPID Name:
Citric acid, Glycolic Acid, DL-Lactic acid, L-Lactic acid, L-Malic acid
Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.
NHPID Name:
Citric acid, Glycolic Acid, DL-Lactic acid, L-Lactic acid, L-Malic acid
Non-NHP Rationale changed:
This ingredient is assigned the role of non-NHP, as listed on the Prescription Drug List:When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3, except when sold to be applied to warts, corns or calluses.
NHPID Name:
Citric acid monohydrate, DL-Malic acid, D-Malic acid
Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.
NHPID Name:
Citric acid monohydrate, DL-Malic acid, D-Malic acid
Non-NHP Rationale changed:
This ingredient is assigned the role of non-NHP, as listed on the Prescription Drug List:When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3, except when sold to be applied to warts, corns or calluses.
NHPID Name:
dl-Mandelic acid
New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.
NHPID Name:
dl-Mandelic acid
Non-NHP Rationale changed:
This ingredient is assigned the role of non-NHP, as listed on the Prescription Drug List:When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3, except when sold to be applied to warts, corns or calluses.
NHPID Name:
dl-Mandelic acid
Additional Details changed:
Information regarding the pH levels and the quantity of Mandelic acid contained in the product must also be submitted.
NHPID Name:
DL-Tartaric acid, D-Tartaric acid, L-Tartaric acid
New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.
NHPID Name:
Xylitol
New NMI Purpose(s):
Skin-Conditioning Agent
NHPID Name:
D-Mannitol
New NMI Purpose(s):
Skin-Conditioning Agent
NHPID Name:
Isododecane
New NMI Purpose(s):
Emollient
NHPID Name:
Decyl D-glucoside
New NMI Purpose(s):
Emulsion Stabilizer
NHPID Name:
1,3-Butylene glycol
New NMI Purpose(s):
Humectant
NHPID Name:
Hydrolyzed beef protein
New Source Material(s) added:
Bos taurus ( Parts: Muscle )
Monograph Modifications
In this update, the following single ingredient or product monographs were added or modified.
No Changes.
AbLS Modifications
In this update, the following abbreviated labelling standards were added or modified.
No Changes.
Controlled Vocabulary Modifications
In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.
No Changes.
Homeopathic Ingredient Modifications
In this update, the following homeopathic ingredients were added or modified.
No Changes.
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