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Drugs and Health Products

Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on November 15, 2016.

ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest version of the e-PLA, namely version 2.3.1, which is available for downloading from e-PLA 2.3.1


New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Opuntia Ficus-Indica Fruit Extract

Role:
Non-medicinal


NHPID Name:
Palmitoyl Hexapeptide-14

Role:
Non-medicinal


NHPID Name:
Diglucosyl Gallic Acid

Role:
Non-medicinal


NHPID Name:
Diethyl sebacate

Role:
Decanedioic acid, diethyl ester


NHPID Name:
Rhodiola Rosea Root Extract

Role:
Non-medicinal


NHPID Name:
Crotonaldehyde

Role:
Non-medicinal


NHPID Name:
Phosphoethanolamine

Role:
Medicinal


NHPID Name:
PEG-32 Stearate

Role:
Non-medicinal


NHPID Name:
Labisia pumila

Role:
Medicinal


Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

No Changes.


Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

Old NHPID Name:
Ethyl sebacate

New NHPID Name:
Diethyl sebacate


Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Carrot Seed Oil

New Common Name(s):
Carrot Seed Essential Oil


NHPID Name:
Carrot Seed Oil

New Common Name(s):
Daucus Carota Sativa (Carrot) Seed Oil


NHPID Name:
Ophiocordyceps sinensis

New Common Name(s):
Dong chong xia cao; Cordyceps; Chinese Caterpillar Fungus; Cordyceps sinensis


New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
Morpholine

Old Role:
Non-medicinal

New Role:
No role


Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Diethylene glycol

Non-medicinal Restriction(s) changed:
For use in topical rinse-off products only. Not permitted in oral or leave-on products.


NHPID Name:
Herba Artemisiae Annuae, Herba Artemisiae Anomalae, Herba Artemisiae Scopariae

New Medicinal Restriction(s) added :
Artemisia species contain thujone. For adults, the upper limit for total daily intake of thujone from health products is 6 mg. Product licence applications for oral products should include a copy of a certificate of analysis or any other equivalent document demonstrating that the thujone content of a daily dose of the product is acceptable. Because thujone content of the herbal materials can vary, the thujone content should be determined for each batch during production of the product.


Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Methoxyisopropanol

New Toxicity restriction added:
Maximum of 0.5% 2-methoxypropanol (CAS Registry Number: 1589-47-5).


NHPID Name:
Methoxyisopropanol

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included as an ingredient in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Isobutane

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included as an ingredient in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Inula Helenium Extract

New Additional Details added :
The presence of the ingredient "Inula helenium oil" as a prohibited substance on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. Inula helenium oil cannot be used in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/person/cosmet/info-ind-prof/_hot-list-critique/prohibited-eng.php


NHPID Name:
Placental protein

New Additional Details added :
The presence of the ingredient "Human placental protein" on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included as an ingredient in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Morpholine

New Additional Details added :
The presence of this ingredient without conditions on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient cannot be used in topical natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/person/cosmet/info-ind-prof/_hot-list-critique/prohibited-eng.php.


NHPID Name:
Gold

New Additional Details added :
The presence of the ingredient "Gold salts" as a prohibited substance on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. Gold salts cannot be used in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php


NHPID Name:
Diethylene glycol

New Additional Details added :
The presence of the ingredient "Gold salts" as a prohibited substance on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. Gold salts cannot be used in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php


NHPID Name:
Aluminum chloride

New Additional Details added :
The presence of the ingredient "Gold salts" as a prohibited substance on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. Gold salts cannot be used in natural health products without the submission of additional evidence for safety. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php


NHPID Name:
Aluminum chloride

Medicinal Rationale changed:
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, including those with duration statements, are classified as cosmetics. Aluminum-based antiperspirants intended for use in hyperhidrosis, or that imply protection based on a mechanism of action that modifies organic function are classified as NHPs. Reference: http://www.hc-sc.gc.ca/cps-spc/pubs/indust/cosmet-antiperspir-sudorif/index-eng.php.


NHPID Name:
Citric acid, Glycolic Acid, DL-Lactic acid, L-Lactic acid, L-Malic acid

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Citric acid, Glycolic Acid, DL-Lactic acid, L-Lactic acid, L-Malic acid

Non-NHP Rationale changed:
This ingredient is assigned the role of non-NHP, as listed on the Prescription Drug List:When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3, except when sold to be applied to warts, corns or calluses.


NHPID Name:
Citric acid monohydrate, DL-Malic acid, D-Malic acid

Additional Details changed:
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Citric acid monohydrate, DL-Malic acid, D-Malic acid

Non-NHP Rationale changed:
This ingredient is assigned the role of non-NHP, as listed on the Prescription Drug List:When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3, except when sold to be applied to warts, corns or calluses.


NHPID Name:
dl-Mandelic acid

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
dl-Mandelic acid

Non-NHP Rationale changed:
This ingredient is assigned the role of non-NHP, as listed on the Prescription Drug List:When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3, except when sold to be applied to warts, corns or calluses.


NHPID Name:
dl-Mandelic acid

Additional Details changed:
Information regarding the pH levels and the quantity of Mandelic acid contained in the product must also be submitted.


NHPID Name:
DL-Tartaric acid, D-Tartaric acid, L-Tartaric acid

New Additional Details added :
The presence of this ingredient on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potentially significant safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted. Reference: http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php.


NHPID Name:
Xylitol

New NMI Purpose(s):
Skin-Conditioning Agent


NHPID Name:
D-Mannitol

New NMI Purpose(s):
Skin-Conditioning Agent


NHPID Name:
Isododecane

New NMI Purpose(s):
Emollient


NHPID Name:
Decyl D-glucoside

New NMI Purpose(s):
Emulsion Stabilizer


NHPID Name:
1,3-Butylene glycol

New NMI Purpose(s):
Humectant


NHPID Name:
Hydrolyzed beef protein

New Source Material(s) added:
Bos taurus ( Parts: Muscle )


Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

No Changes.


AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.


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