Health Canada
Symbol of the Government of Canada
Drugs and Health Products

Natural Health Products Ingredients Database

WHAT'S NEW

What's New is a listing of modifications to the NHPID since the last update. This page was most recently revised on March 20, 2020.

ANNOUNCEMENTS

The updates to the NHPID listed below apply to the most recent version of the ePLA (electronic Product Licence Application). All new electronic submissions of a Product Licence Application must use the latest version of the e-PLA, namely version 2.3.1, which is available for downloading from e-PLA 2.3.1


New Ingredients

In this update, the following non-homeopathic ingredients were added.

NHPID Name:
Cordyceps Militaris Mycelium Extract

Role:
Non-medicinal


NHPID Name:
Sorbityl Laurate

Role:
Non-medicinal


NHPID Name:
lactobacillus

Role:
Non-medicinal


Removed Ingredients

In this update, the following non-homeopathic ingredients were removed.

No Changes.


Revised NHPID Names

In this update, the following non-homeopathic ingredients had their NHPID name revised.

Old NHPID Name:
Artemisia abrotanum Extract

New NHPID Name:
Artemisia Abrotanum Extract


Revised Proper and Common Names

In this update, the following non-homeopathic ingredients had their common or proper names revised.

NHPID Name:
Diisopropanolamine

New Proper Name(s):
1,1'-Iminodipropan-2-ol


NHPID Name:
Diisopropanolamine

Removed Proper Name(s):
Diisopropanolamine


NHPID Name:
Diisopropanolamine

New Common Name(s):
Diisopropanolamine


NHPID Name:
Diisopropanolamine

Removed Common Name(s):
1,1'-Iminodipropan-2-ol


NHPID Name:
Diisopropanolamine

Removed Common Name(s):
2-Propanol, 1,1'-iminobis-


NHPID Name:
isopropanolamine

New Proper Name(s):
1-Amino-2-propanol


NHPID Name:
isopropanolamine

Removed Proper Name(s):
isopropanolamine


NHPID Name:
isopropanolamine

New Common Name(s):
isopropanolamine


NHPID Name:
triisopropanolamine

Removed Proper Name(s):
triisopropanolamine


NHPID Name:
triisopropanolamine

New Proper Name(s):
1,1',1"-Nitrilotris-2-propanol


NHPID Name:
Artemisia Abrotanum Extract

Removed Common Name(s):
Southern wormwood Extract


NHPID Name:
Artemisia Abrotanum Extract

Removed Common Name(s):
Artemisia abrotanum Extract


NHPID Name:
Artemisia Abrotanum Extract

New Common Name(s):
Artemisia abrotanum extract


New Roles

In this update, the roles of the following non-homeopathic ingredients were changed.

NHPID Name:
Magnesium ascorbate

Old Role:
Medicinal

New Role:
No role


NHPID Name:
DL-Tartaric acid

Old Role:
No role

New Role:
Non-NHP


NHPID Name:
D-Tartaric acid

Old Role:
No role

New Role:
Non-NHP


NHPID Name:
L-Tartaric acid

Old Role:
No role

New Role:
Non-NHP


Revised Restrictions

In this update, the following non-homeopathic ingredients underwent a modification related to their restrictions.

NHPID Name:
Diisopropanolamine

New Route(s) of Adminstration added:
Topical


NHPID Name:
Diisopropanolamine

New Restriction Reference added:
CIR


NHPID Name:
Diisopropanolamine

Restriction Reference removed:
UNAVA


NHPID Name:
isopropanolamine

New Restriction Reference added:
CIR


NHPID Name:
isopropanolamine

Restriction Reference removed:
UNAVA


NHPID Name:
triisopropanolamine

New Restriction Reference added:
CIR


NHPID Name:
triisopropanolamine

Restriction Reference removed:
ICID


NHPID Name:
Tetrahydrocurcuminoids

Non-medicinal Restriction(s) removed:
General


NHPID Name:
alpha-Cyclodextrin

Non-medicinal Restriction(s) removed:
General


NHPID Name:
gamma-Cyclodextrin

Non-medicinal Restriction(s) removed:
General


NHPID Name:
Cinnamomum Zeylanicum Leaf Oil

Non-medicinal Restriction(s) removed:
General


NHPID Name:
Cinnamomum Zeylanicum Leaf Oil

New Restriction Reference added:
EQSAFTY2


NHPID Name:
Cinnamomum Zeylanicum Leaf Oil

Restriction Reference removed:
CosIng


NHPID Name:
Cinnamon Essential Oil

Non-medicinal Restriction(s) changed:
Acceptable daily intake added: Upper Limit:2.5 Units:Milligrams/kilogram body weight/day Route Of Administration:Oral Detail:Acceptable daily intake up to 2.5 mg/kg bw/day, expressed as eugenol equivalents. Reference:WHO_JECFA


NHPID Name:
Turpentine essential oil

Non-medicinal Restriction(s) removed:
General


NHPID Name:
Shark Liver Oil

New Route(s) of Adminstration added:
Topical


Other Ingredient Modifications

In this update, the following non-homeopathic ingredients underwent a modification different from those listed above, such as new source material, new preparation type, or new sub-ingredient relationship, etc.

NHPID Name:
Proanthocyanidins

New Source Material(s) added:
Pinus pinaster (Parts: Stem bark)


NHPID Name:
Glucosamine hydrochloride

New Source Material(s) added:
Escherichia coli (Parts: Whole Cell for Biosynthesis)


NHPID Name:
Diisopropanolamine

Modification:
New Restriction detail: For topical use only, up to 0.7%, and not to be used in products containing N-nitrosating agents.


NHPID Name:
isopropanolamine

Modification:
New Restriction detail: For topical use only, up to 1%, and not to be used in products containing N-nitrosating agents.


NHPID Name:
triisopropanolamine

Modification:
Revised Restriction detail: For topical use only, up to 1%, and not to be used in products containing N-nitrosating agents.


NHPID Name:
phytosterols

New Source Material(s) added:
Pinus sylvestris (Parts: Trunk bark)


NHPID Name:
Tetrahydrocurcuminoids

Modification:
Revised Schedule 1: Extract


NHPID Name:
Tetrahydrocurcuminoids

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 2 (an extract) of the Natural Health Products Regulations.


NHPID Name:
Magnesium ascorbate

Modification:
Removed Schedule 1: Synthetic duplicate


NHPID Name:
alpha-Cyclodextrin

Modification:
Revised Schedule 1: Isolate


NHPID Name:
alpha-Cyclodextrin

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 2 (an isolate) of the Natural Health Products Regulations.


NHPID Name:
gamma-Cyclodextrin

Modification:
Revised Schedule 1: Isolate


NHPID Name:
gamma-Cyclodextrin

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 2 (an isolate) of the Natural Health Products Regulations.


NHPID Name:
Cinnamomum Zeylanicum Leaf Oil

New Name Reference added:
ICID


NHPID Name:
Cinnamomum Zeylanicum Leaf Oil

Modification:
Removed Schedule 1: Extract


NHPID Name:
Cinnamomum Zeylanicum Leaf Oil

Method(s) of Preparation removed:
Oil, Essential (water steam distillation) Standardized


NHPID Name:
Cinnamomum Zeylanicum Leaf Oil

Removed NMI purpose(s):
Flavour Enhancer - Natural


NHPID Name:
Cinnamomum Zeylanicum Leaf Oil

Modification:
Revised Restriction detail: For topical use only, up to 6%.


NHPID Name:
Cinnamon Essential Oil

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 2 (an extract) of the Natural Health Products Regulations.


NHPID Name:
Turpentine essential oil

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 2 (an extract) of the Natural Health Products Regulations.


NHPID Name:
Turpentine oil

Modification:
Revised Parts: Gum oleoresin


NHPID Name:
Turpentine oil

Method(s) of Preparation removed:
Oil, Essential (water steam distillation) Standardized, Oil, Essential (enfleurage); Oil, Essential (enfleurage) Standardized; Oil, Essential (expression); Oil, Essential (expression) Standardized; Oil, Essential (other methods of preparation); Oil, Essential (other methods of preparation) Standardized


NHPID Name:
Turpentine oil

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 2 (an extract) of the Natural Health Products Regulations.


NHPID Name:
Turpentine oil

Modification:
New Restriction detail: For topical use only


NHPID Name:
Artemisia Abrotanum Extract

Modification:
Removed Schedule 1: plant and plant material


NHPID Name:
Artemisia Abrotanum Extract

New Source Material(s) added:
Artemisia abrotanum (Parts: Whole plant)


NHPID Name:
Artemisia Abrotanum Extract

Source Material(s) removed:
Artemisia abrotanum (Parts: Whole)


NHPID Name:
Artemisia Abrotanum Extract

Method(s) of Preparation removed:
Extract dry standardized; Extract liquid standardized


NHPID Name:
Artemisia Abrotanum Extract

Modification:
New Restriction detail: For topical use only


NHPID Name:
Artemisia Vulgaris Extract

Modification:
Removed Schedule 1: Extract


NHPID Name:
Artemisia Vulgaris Extract

Method(s) of Preparation removed:
Extract dry standardized; Extract liquid standardized


NHPID Name:
Artemisia Vulgaris Extract

Modification:
New Restriction detail: For topical use only


NHPID Name:
Artemisia Pallens Flower Oil

Modification:
Removed Schedule 1: Extract


NHPID Name:
Artemisia Pallens Flower Oil

Method(s) of Preparation removed:
Oil, Essential (water steam distillation) Standardized


NHPID Name:
Artemisia Pallens Flower Oil

Modification:
New Restriction detail: For topical use only


NHPID Name:
Artemisia princeps leaf extract

Modification:
Removed Schedule 1: plant and plant material


NHPID Name:
Artemisia princeps leaf extract

Method(s) of Preparation removed:
Extract dry standardized; Extract liquid standardized


NHPID Name:
Artemisia princeps leaf extract

Modification:
New Restriction detail: For topical use only


NHPID Name:
Lamna nasus (porbeagle shark) cartilage

New Additional Details added :
It should be noted that Lamna nasus (porbeagle shark) is listed on Appendix II of the Convention on International Trade in Endangered Species of Wild Fauna and Flora.


NHPID Name:
Lamna nasus (porbeagle shark) cartilage

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 1 (a non-human animal material) of the Natural Health Products Regulations.


NHPID Name:
Shark cartilage

Additional Details changed:
Sharks are organisms in the orders Carcharhiniformes, Heterodontiformes, Hexanchiformes, Lamniformes, Orectolobiformes, Pristiophoriformes, Squaliformes, and Squatiniformes. It should be noted that this ingredient may be subject to additional regulatory requirements depending on its source material species in accordance with the Species at Risk Act and/or the Convention on International Trade in Endangered Species of Wild Fauna and Flora.


NHPID Name:
Shark cartilage

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 1 (a non-human animal material) of the Natural Health Products Regulations.


NHPID Name:
Shark Liver Oil

Additional Details changed:
Sharks are organisms in the orders Carcharhiniformes, Heterodontiformes, Hexanchiformes, Lamniformes, Orectolobiformes, Pristiophoriformes, Squaliformes, and Squatiniformes. It should be noted that this ingredient may be subject to additional regulatory requirements depending on its source material species in accordance with the Species at Risk Act and/or the Convention on International Trade in Endangered Species of Wild Fauna and Flora.


NHPID Name:
Shark Liver Oil

Medicinal Rationale changed:
Classified as an NHP under Schedule 1, item 2 (an extract) of the Natural Health Products Regulations.


NHPID Name:
L-Malic acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
L-Malic acid

Non-NHP Rationale changed:
A non-NHP when the product is captured by the Prescription Drug List: When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3.0, except when sold to be applied to warts, corns or calluses.


NHPID Name:
Citric acid monohydrate

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
Citric acid monohydrate

Non-NHP Rationale changed:
A non-NHP when the product is captured by the Prescription Drug List: When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3.0, except when sold to be applied to warts, corns or calluses.


NHPID Name:
DL-Malic acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
DL-Malic acid

Non-NHP Rationale changed:
A non-NHP when the product is captured by the Prescription Drug List: When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3.0, except when sold to be applied to warts, corns or calluses.


NHPID Name:
D-Malic acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
D-Malic acid

Non-NHP Rationale changed:
A non-NHP when the product is captured by the Prescription Drug List: When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3.0, except when sold to be applied to warts, corns or calluses.


NHPID Name:
Citric acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
Citric acid

Non-NHP Rationale changed:
A non-NHP when the product is captured by the Prescription Drug List: When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3.0, except when sold to be applied to warts, corns or calluses.


NHPID Name:
Glycolic Acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
Glycolic Acid

Non-NHP Rationale changed:
A non-NHP when the product is captured by the Prescription Drug List: When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3.0, except when sold to be applied to warts, corns or calluses.


NHPID Name:
D-Lactic acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
D-Lactic acid

Non-NHP Rationale changed:
A non-NHP when the product is captured by the Prescription Drug List: When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3.0, except when sold to be applied to warts, corns or calluses.


NHPID Name:
DL-Lactic acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
DL-Lactic acid

Non-NHP Rationale changed:
A non-NHP when the product is captured by the Prescription Drug List: When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3.0, except when sold to be applied to warts, corns or calluses.


NHPID Name:
L-Lactic acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
L-Lactic acid

Non-NHP Rationale changed:
A non-NHP when the product is captured by the Prescription Drug List: When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3.0, except when sold to be applied to warts, corns or calluses.


NHPID Name:
dl-Mandelic acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
dl-Mandelic acid

Non-NHP Rationale changed:
A non-NHP when the product is captured by the Prescription Drug List: When sold in topical formulations containing alpha hydroxy acids alone or in combination at concentrations greater than 30% and/or with a pH lower than 3.0, except when sold to be applied to warts, corns or calluses.


NHPID Name:
DL-Tartaric acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
D-Tartaric acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


NHPID Name:
L-Tartaric acid

Additional Details changed:
The presence of this ingredient as restricted on the List of Prohibited and Restricted Cosmetic Ingredients (the Cosmetic Ingredient Hotlist) indicates that there are potential safety issues. This ingredient must be used in accordance with the restrictions set out on the Hotlist when included in natural health products, unless additional evidence for safety is submitted.


Monograph Modifications

In this update, the following single ingredient or product monographs were added or modified.

No Changes.


AbLS Modifications

In this update, the following abbreviated labelling standards were added or modified.

No Changes.


Controlled Vocabulary Modifications

In this update, the following controlled vocabulary (dosage forms, methods of preparation, quality test methods, etc) were added or modified.

No Changes.


Homeopathic Ingredient Modifications

In this update, the following homeopathic ingredients were added or modified.

No Changes.

RemIng

PREVIOUS WHAT'S NEW