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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.
|Proper name(s)1||Common name(s)1,2||Source material(s)1,2|
|Glycine max (L.) Merr.||Soy flour
|Glycine max (L.) Merr.||Defatted soy flour3
Defatted soybean flour3
Up to 8 g soy flour per day (Tomar and Shiao 2008; Travis et al. 2008).
5.5 — 8 g defatted soy flour per day (CNF 2010; Travis et al. 2008; IOM 2002)
Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.
CNF 2010: Canadian Nutrient File. Canadian Nutrient File, Ottawa (ON): Food and Nutrition, Health Canada. TEXT3. [Date Modified 2012 April 26; Accessed 2014 September 15].
CFIA 2012: Canadian Food Inspection Agency. Food Labelling for Industry, Ottawa (ON): Canadian Food Inspection Agency and Health Canada. Internet. [Date modified 2013 July 22].
IOM 2002: Institute of Medicine of the National Academies. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Food and Nutrition Board, Institute of Medicine. Washington (DC): National Academy Press; 2002.
Liu J, Chang SK, Wiesenborn D. Antioxidant properties of soybean isoflavone extract and tofu in vitro and in vivo. Journal of Agricultural and Food Chemistry 2005;53(6):2333-40.
Tomar RS, Shiao R. Early life and adult exposure to isoflavones and breast cancer risk. Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews 2008;26(2):113-173.
Travis RC, Allen NE, Appleby PN, Spencer EA, Roddam AW, Key TJ. A prospective study of vegetarianism and isoflavone intake in relation to breast cancer in British women. International Journal of Cancer 2008;122:705-10.
USDA 2006: United States Department of Agriculture, Agricultural Research Service, National Genetic Resources Program. Germplasm Resources Information Network (GRIN) . [Internet]. 2006. Glycine max (L) Merr. Beltsville (MD): National Germplasm Resources Laboratory. [Accessed 2014 September 16].
Wang Q, Ge X, Tian X, Zhang Y, Zhang J, Zhang P. Soy isoflavone : The multipurpose phytochemical (Review). Biomedical Reports 2013;1(5):697-701.
Cederroth CR, Auger J, Zimmermann C, Eustache F, Nef S. Soy, phyto-oestrogens and male reproductive function: a review. International Journal of Andrology 2010;33(2):304-16.
Chavarro JE, Toth TL, Sadio SM, Hauser R. Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic. Human Reproduction 2008;23:2584-2590
Doerge DR. Bioavailability of soy isoflavones through placental/lactational transfer and soy food. Toxicology and Applied Pharmacology 2011;254(2):145-
Wang H-J, Murphy PA. Mass balance study of isoflavones during soybean processing. Journal of Agricultural and Food Chemistry 1996;44(8):2377-2383.
Yu C, Tai F, Zeng S, Zhang X. Effects of perinatal daidzein exposure on subsequent behavior and central estrogen ? expression in the adult male mouse. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2013;43:157-167.