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Drugs and Health Products

Red Wine Extract (Under Consultation)

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.

Notes

  • Text in parentheses is additional optional information which can be included on the PLA and product label at the applicant's discretion.
  • The solidus (/) indicates that the terms and/or the statements are synonymous. Either term or statement may be selected by the applicant.

Date

March 7, 2014

Proper name(s)

Vitis vinifera(L.)(Vitaceae) (USDA 2009)

Common name(s)

Red Wine Extract, Red Wine Polyphenol Extract (Leifert and Abeywardena 2008)

Source material(s)

Fruit (Nigdikar et al. 1998; Brouillard et al. 1997)

Route(s) of administration

Oral

Dosage form(s)

  • The acceptable pharmaceutical dosage forms include, but are not limited to capsules, chewables (e.g. gummies, tablets), liquids, powders, strips or tablets.
  • This monograph is not intended to include foods or food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s)

Statement(s) to the effect of:

Provides antioxidants (Meskin et al. 2002; Cuevas et al. 2000).

Dose(s)

Subpopulation

Adults (≥ 18 years)

Quantity(ies)

Up to 1g red wine extract, per day (Chopra et al. 2000; Cuevas et al. 2000; Nigdikar et al. 1998).

Potency (Optional): Up to 95 % polyphenols (Botden et al. 2012; Chopra et al. 2000).

Duration of use

No statement required.

Risk Information

Statement(s) to the effect of:

Caution(s) and warning(s)

If you are pregnant or breastfeeding, consult a health care practitioner prior to use (Meskin et al. 2002).

Contraindication(s)

No statement required.

Known adverse reaction(s)

No statement required.

Non-medicinal Ingredients

Must be chosen from the current NNHPD Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage Conditions

No statement required.

Specifications

References cited

  • Botden I, Draijer R, Westerhof B, Rutten J, Langendonk J, Sijbrands E, Danbser A, Zock P, Meiracker A. Red wine polyphenols do not lower peripheral or central blood pressure in high normal blood pressure and hypertension. American Journal of Hypertension 2012; 25 (6): 718-723.
  • Brouillard R, George F, Fougerousse A. Polyphenols produced during red wine ageing. Biofactors 1997;6:403-410.
  • Cuevas AM, Guasch V, Castillo O, Irribarra V, Mizon C, San Martin A, Strobel P, Perez D, Germain AM, Leighton F. A High-Fat Induces and Red Wine Counteracts Endothelial Dysfunction in Human Volunteers. Lipids 2000;35(2):143-148.
  • Chopra M, Fitzsimons PE, Strain JJ, Thurnham DI, Howard AN. Nonalcoholic Red Wine Extract and Quercetin Inhibit LDL Oxidation without Affecting Plasma Antioxidant Vitamin and Carotenoid Concentrations. Clinical Chemistry 2000;46(8):1162-1170.
  • Leifert, W.R. Abeywardena, M.Y. Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity. Nutrition Research 2008;28: 842-850.
  • Meskin MS, Bidlack WR, Davies AJ, Omaye ST. Phytochemicals in nutrition and health. CRC Press LLC. Boca Raton, Florida;2002:46-60.
  • Nigdikar SV, Williams NR, Griffin BA, Howard AN. Red Wine Polyphenols and LDL Oxidation. American Journal of Clinical Nutrition 1998;68:258-265.
  • USDA 2009: United States Department of Agriculture, Agricultural Research Service, National Genetic Resources Program.Le lien suivant vous amène à un autre site Web Germplasm Resources Information Network (GRIN). National Germplasm Resources Laboratory, Beltsville (MD). [Vitis vinifera L. Last updated 2009 May 23; Accessed 2013 July 25].

References reviewed

  • Blumenthal M. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin (TX): American Botanical Council in cooperation with Integrative Medicine Communications;1998.
  • Bove M. An Encyclopedia of Natural Healing for Children and Infants. 2nd edition. New York (NY): McGraw-Hill Publishing, Incorporated;2001.
  • Brinker F. Herb Contraindications and Drug Interactions, 3rd edition. Sandy (OR): Eclectic Medical Publications;2001.
  • Merck 2012:Le lien suivant vous amène à un autre site Web  The Merck Index Version 14.1. Whitehouse Station (NJ): Merck & Co., Inc. Copyright © 2006, 2012 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. [Published 2006; Updated 2012; Accessed 2013 August 12].
  • Pizzorno JE, Murray MT, editors. Textbook of Natural Medicine. Third edition, volume 1. St. Louis (MI): Churchill Livingstone Elsevier;2006.
  • Schilcher H. Phytotherapy in Paediatrics: Handbook for Physicians and Pharmacists: With reference to Commission E Monographs of the Federal Department of Health in Germany. Includes 100 Commission E monographs and 15 ESCOP Monographs. Stuttgart (DE): Medpharm Scientific Publishers;1997.
  • Sweetman SC, editor. Martindale:Le lien suivant vous amène à un autre site Web  The Complete Drug Reference. London (GB): Pharmaceutical Press; 2011. [Arnica: Last modified 2010 November 27; Accessed 2011 February 1]