Linden, Large-Leaf - TILIA PLATYPHYLLOS

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.

Notes

Date

July 18, 2017

Proper name(s)

Tilia platyphyllos Scop. (Tiliaceae) (USDA 2008)

Common name(s)

Source material(s)

Flower (Bradley 1992; Felter and Lloyd 1983 [1898])

Route(s) of administration

Oral

Dosage form(s)

This monograph is not intended to include foods or food-like dosage forms such as bars, chewing gums or beverages.

Dosage forms by age group:

Use(s) or Purpose(s)

Dose(s)

Table 1: Dose information for linden flower presented as dose per day

Subpopulation Linden flower (g/day)
Minimum Maximum

Table 1 Footnotes

Table 1 Footnote 1

Children and adolescent doses were calculated as a fraction of the adult dose (JC 2008). The use of linden in children and adolescents is supported by the following references: McIntyre 2005; Schilcher 1997; Bove 1996.

Return to Table 1 footnote1 referrer

Table 1 Footnote 2

Adult dose supported by the following references: Hoffmann 2003; Blumenthal et al. 2000; Bradley 1992; Felter and Lloyd 1983[1898].

Return to Table 1 footnote2 referrer

Table 1 Footnote 3

Includes pregnant and breastfeeding women

Return to Table 1 footnote3 referrer

Children 1 2-4 y 0.2 2
Children and adolescents 1 5-9 y 0.4 3
Adolescents 1 10-14 y 0.8 6
Adolescents and adults 1,2,3 ≥ 15 y 1.5 12

Note: See Appendix 1 for examples of appropriate dosage preparations, frequencies of use and directions for use, according to cited references. The purpose of Appendix 1 is to provide guidance to industry.

Duration of use

No statement required.

Risk information

Caution(s) and warning(s)

Consult a health care practitioner prior to use if symptoms persist or worsen.

Contraindication(s)

No statement required.

Known adverse reaction(s)

Hypersensitivity and/or an allergy are known to occur; in which case, discontinue use (Mills and Bone 2005; De Smet 1993).

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Specifications

References cited

References reviewed

Appendix 1: Examples of appropriate dosage preparations, frequencies of use and directions for use

Dried flower:

2-4 g, per day (Blumenthal et al. 2000)

Infusion:

Directions for use:

Pour 150 ml to 473 ml (1 pint) of boiling water over dried flowers and infuse for 10-15 minutes (Hoffmann 2003; Blumenthal et al. 2000; Felter and Lloyd 1983 [1898]).
1.8 g = 1 tsp. (Wichtl 2004)

Fluidextract:

Tincture: