Santé Canada
Symbole du Gouvernement du Canada
Médicaments et produits de santé

PRODUITS DE VARECH

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La présente monographie vise à servir de guide à l'industrie pour la préparation de demandes de licence de mise en marché (DLMM) et d'étiquettes dans le but d'obtenir une autorisation de mise en marché d'un produit de santé naturel. Elle ne vise pas à être une étude approfondie de l'ingrédient médicinal.

Nota

  • Les parenthèses contiennent des éléments d'information additionnels (facultatifs) qui peuvent être inclus dans la DLMM ou sur l'étiquette du produit à la discrétion du demandeur.
  • La barre oblique (/) indique que les termes ou les énoncés sont synonymes. Le demandeur peut utiliser n'importe lequel des termes ou énoncés indiqués.

Date

25 septembre 2018

Nom(s) propre(s), Nom(s) commun(s), Matière(s) d'origine

Tableau 1. Nom(s) propre(s), Nom commun(s), Matière(s) d'origine
Nom(s) propre(s) Nom(s) commun(s)
Matière(s) d'origine
Nom(s) propre(s) Partie(s)

Ascophyllum nodosum

  • Kuppetang
  • Varech norvégien

Ascophyllum nodosum

  • Thalle
  • Entier

Fucus vesiculosus

  • Chone marin
  • Kelpware
  • Varech noueux
  • Varech vésiculeux

Fucus vesiculosus

  • Thalle
  • Entier

Laminaria digitata

  • Fouet de sorcier
  • Laminaire digitée
  • Varech
Laminaria digitata
  • Thalle
  • Entier
Laminaria japonica
  • Enchevêtrement de mer
  • Hai dai
  • Makombu
  • Varech japonais
Laminaria japonica
  • Thalle
  • Entier

Références: Nom propre: Guiry et Guiry 2018a,b; Noms communs: TGA 2016, The Biodiversity Committee of Chinese Academy of Science 2013; Matières d'origine: Guiry et Guiry 2018a,b.

Voie d'administration

Orale

Forme(s) posologique(s)

Cette monographie exclut les aliments et les formes posologiques semblables aux aliments tel qu'indiqué dans le document de référence Compendium des monographies.

Les formes posologiques acceptables pour les catégories d'âge listées dans cette monographie et pour la voie d'administration spécifiée sont indiquées dans le document de référence Compendium des monographies.

Usage(s) ou fin(s)

Tous les produits

  • Source d'antioxydants/Fournit des antioxydants (Murphya et al. 2013; FCÉN 2012; Kang et al. 2012; Veena et al. 2008; Veena et al. 2007; Zhang et al. 2007; Jin et al. 2004).
  • Source d'antioxydants/Fournit des antioxydants qui aident à combattre/à protéger (les cellules) contre/à réduire (les effets oxydatifs des/les dommages oxydatifs causés par/les dommages cellulaires causés par) les radicaux libres (Murphya et al. 2013; FCÉN 2012; Kang et al. 2012; Veena et al. 2008; Veena et al. 2007; Zhang et al. 2007; Jin et al. 2004).

Produits fournissant 0,8 g ou plus de Fucus vesiculosus par jour

  • Utilisé traditionnellement en phytothérapie comme un altératif du système glandulaire (Hoffman 2003; Duke 2002; Grieve 1931a,b; Felter et Lloyd 1898).
  • Utilisé en phytothérapie pour soutenir le fonctionnement normal de la glande thyroïde (Bradley 1992; Grieve 1931a,b; Ellingwood 1919).

Produits normalisés à l'iode

Selon la monographie des Suppléments de multivitamines/minéraux de la Direction des produits de santé naturels et sans ordonnance (DPSNSO).

Nota

Les allégations pour les usages traditionnels doivent inclure le terme « phytothérapie », « médecine traditionnelle chinoise » ou « Ayurvéda ».

Dose(s)

Sous-population(s)

Adultes 18 ans et plus

Quantité(s)

Antioxydants

Méthodes de préparation : Sec, poudre, extraits éthanoliques non normalisés (teinture, extraits fluides)

Ne pas dépasser 1 gramme de varech par jour (Barnes et al. 2007; Mills et Bone 2005; Kolb et al. 2004; Duke 2002; BHP 1996; Bradley 1992)

Fucus vesiculosus : altératif, fonctionnement normal de la glande thyroïde

0,8 à 1 gramme de Fucus vesiculosus par jour (Mills et Bone 2005; Bradley 1992).

Allégations relatives au iode (monographie des Suppléments de multivitamines/minéraux)

Méthodes de préparation : Préparations normalisées

Les ingrédients médicinaux doivent fournir la quantité d'iode minimale indiquée dans la monographie des Suppléments de multivitamines/minéraux de la DPSNSO. L'iode doit être indiqué sur le formulaire de demande de licence de mise en marché comme composante d'activité.

Nota

La quantité totale d'iode fournie par le produit ne doit pas dépasser 800 microgrammes d'iode par jour (IOM 2006).

Mode(s) d'emploi

Énoncé non requis.

Durée(s) d'utilisation

Énoncé non requis.

Mention(s) de risque

Précaution(s) et mise(s) en garde

Tous les produits

  • Consulter un praticien de soins de santé/fournisseur de soins de santé/professionnel de la santé /docteur/médecin avant d'en faire l'usage si vous prenez des anticoagulants (Gardner et McGuffin 2013; Ren et al. 2013; Zhao et al. 2012; Brinker 2010; Gruenwald et al. 2007; Duke 2002).
  • Consulter un praticien de soins de la santé/fournisseur de soins de santé/professionnel de la santé/docteur/médecin avant d'en faire l'usage si vous êtes enceinte ou si vous allaitez (Brinker 2010; Barnes 2002).

Contre-indications(s)

Énoncé non requis.

Réaction(s) indésirable(s) connue(s)

Énoncé non requis.

Ingrédients non médicinaux

Doivent être choisis parmi ceux de la version actuelle de la Base de données d'ingrédients de produits de santé naturels (BDIPSN) et respecter les restrictions mentionnées dans cette base de données.

Conditions d'entreposage

Énoncé non requis.

Spécifications

  • Les spécifications du produit fini doivent être établies conformément aux exigences décrites dans le Guide de référence sur la qualité des produits de santé naturels de la Direction des produits de santé naturels et sans ordonnance (DPSNSO).
  • L'ingrédient médicinal doit être conforme aux exigences mentionnées dans la BDIPSN.

Références citées

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  • Grieve M. A Modern Herbal. Volume 1. New York (NY): Dover Publications; 1971 [Reprint of 1931a. Harcourt, Brace & Company publication].
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  • Guiry MD, Guiry GM. 2018a. Fucus vesiculosus Linnaeus. AlgaeBase - World-wide electronic publication. National University of Ireland, Galway. [Consulté le 20 juillet 2018]. Disponible à : http://www.algaebase.org.
  • Guiry MD, Guiry GM. 2018b. Laminaria japonica Areschoug. AlgaeBase - World-wide electronic publication. National University of Ireland, Galway. [Consulté le 20 juillet 2018]. Disponible à : http://www.algaebase.org.
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  • Jin DQ, Li G, Kim JS, Yong CS, Kim JA, Huh K. Preventive Effects of Laminaria japonica Aqueous Extract on the Oxidative Stress and Xanthine Oxidase Activity in Streptozotocininduced diabetic rat liver. Biological and Pharmaceutical Bulletin 2004;27(7):1037-1040.
  • Kang YM, Lee BJ, Kim JI, Nam BH, Cha JY, Kim YM, Ahn CB, Choi JS, Choi IS, Je JY. Antioxidant effects of fermented sea tangle (Laminaria japonica) by Lactobacillus brevis BJ20 in individuals with high level of gamma-GT: A randomized double-blind and placebo controlled clinical study. Food and Chemical Toxicology 2012;50:1166-1169.
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  • Murphya P, Dal Bello F, O'Doherty J, Arendt EK, Sweeney T, Coffey A. The effects of liquid versus spray-dried Laminaria digitata extract on selected bacterial groups in the piglet gastrointestinal tract (GIT) microbiota. Anaerobe 2013;21:1-8.
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  • Zhang J, Tiller C, Shen J, Wang C, Girouard GS, Dennis D, Barrow CJ, Miao M, Ewart HS. Antidiabetic properties of polysaccharide- and polyphenolic-enriched fractions from the brown seaweed Ascophyllum nodosum. Canadian Journal of Physiology and Pharmacology 2007;85(11):1116-1123.
  • Zhao X, Dong S, Wang J, Li F, Chen A, Li B. A comparative study of antithrombotic and antiplatelet activities of different fucoidans from Laminaria japonica. Thrombosis Research 2012;129(6):771-778.

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