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Drugs and Health Products

Green Coffee Bean Extract

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.


  • Text in parentheses is additional optional information which can be included on the PLA and product label at the applicant’s discretion.
  • The solidus (/) indicates that the terms and/or the statements are synonymous. Either term or statement may be selected by the applicant.


October 7, 2014

Proper Name(s)

  • Coffea arabica L. (Rubiaceae) (USDA 2013) and/or
  • Coffea canephora Pierre ex A. Froehner (Rubiaceae) (USDA 2013)

Common name(s)

Green coffee bean extract (Kozuma et al. 2005)

Source material(s)

Seed(Bean)( Kozuma et al. 2005)

Route(s) of administration


Dosage form(s)

  • The acceptable pharmaceutical dosage forms include, but are not limited to capsules, chewables (e.g. gummies, tablets), liquids, powders, strips or tablets.
  • This monograph is not intended to include foods or food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s)

Statement(s) to the effect of:

  • Could be a complement to a healthy lifestyle that incorporates a calorie-reduced diet and regular physical activity for individuals involved in a weight management program (Thom 2007; Dellalibera et al. 2006).
  • Helps maintain healthy blood pressure levels (Mubarak et al. 2012; Watanabe et al. 2006; Kozuma et al. 2005).
  • Helps support cardiovascular health (Mubarak et al. 2012; Watanabe et al. 2006; Kozuma et al. 2005).
  • Provides antioxidants (Farah et al. 2008; Castellucio et al. 1995).



Adults (≥ 18 years)


Weight Management
400-1000 mg extract per day, providing 180-500 mg chlorogenic acids and up to 40 mg caffeine per day. Note that chlorogenic acids potency must be 45 – 50% (Thom 2007; Dellalibera et al. 2006).

Blood pressure and Cardiovascular health
Up to 1000 mg extract per day, providing 50-500 mg chlorogenic acids and up to 40 mg caffeine per day (Thom 2007; Watanabe et al. 2006; Kozuma et al. 2005). 

Up to 1000 mg extract per day, providing up to 500 mg chlorogenic acids and 40 mg caffeine per day (Thom 2007).

Duration of use

No statement required.

Risk information 

Statement(s) to the effect of

Caution(s) and Warning(s)

If you are breastfeeding, consult a health care practitioner prior to use.


If you are pregnant, do not use this product. 

Known adverse reaction(s)

No statement required.

Non-medicinal ingredients

Must be chosen from the current NNHPD Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage Conditions

No statement required.


References cited

  • Castelluccio C, Paganga G, Melikian N, Bolwell GP, Pridham J, Sampson J, Rice-Evans C. Antioxidant potential of intermediates in phenylpropanoid metabolism in higher plants. FEBS Letters 1995;368(1):188-192. 
  • Dellalibera O, Lemaire B and Lafay S. Svetol®, green coffee extract, induces weight loss and increases lean to fat ratio in volunteers with overweight problems. Phytotherapie 2006;4(4):194–197.
  • Kozuma K, Tsuchiya S, Kohori J, Hase T and Tokimitsu I. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertension Research: Official Journal of the Japanese Society of Hypertension 2005;28(8):711-718. 
  • Mubarak A, Bondonno CP, Liu AH, Considine MJ, Rich L, Mas E, Croft KD, Hodgson JM. Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial. Journal of Agricultural and Food Chemistry 2012;60:9130-9136. 
  • Thom E. The Effect of Chlorogenic Acid Enriched Coffee on Glucose Absorption in Healthy Volunteers and Its Effect on Body Mass When Used Long-term in Overweight and Obese People. The Journal of International Medical Research 2007;35(6):900-908.
  • USDA 2013: United States Department of Agriculture, Agricultural Research Service, National Genetic Resources Program.Next link will take you to another Web site Germplasm Resources Information Network (GRIN). [Internet]. National Germplasm Resources Laboratory, Beltsville (MD). [Coffea Arabica L. Last updated 2013 January 27; Accessed 2013 September 13] and [Coffea canephora Pierre ex A. Froehner. Last updated 2013 January 27; Accessed 2013 September 13].
  • Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, Kajihara Y, Saito I. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential  hypertension. Clinical and Experiemntal Hypertension 2006;28(5):439-449. 

References reviewed

  • Blum J, Lemaire B, and Lafay S. Effect of a green decaffeinated coffee extract on glycemia - A pilot prospective clinical study. NUTRAfoods 2007;6(3):13-17. 
  • Farah A, Monteiro M, Donangelo CM, Lafay S. Chlorogenic acids from green coffee extract are highly bioavailable in humans. The Journal of Nutrition 2008;138:2309-2315. 
  • Henry-Vitrac C, Ibarra A, Roller M, Mérillon JM, Vitrac X. Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. Journal of Agricultural and Food Chemistry 2010;58:4141-4144. 
  • Ochiai R, Jokura H, Suzuki A, Tokimitsu I, Ohishi M, Komai N, Rakugi H, Ogihara T. Green coffee bean extract improves human vasoreactivity. Hypertension Research 2004;27(10):731-737. 
  • Olthof MR, Hollmann PCH and Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. The Journal of Nutrition 2001;131:66-71. 
  • Yamaguchi T, Chikama A, Mori K, Watanabe T, Shioya Y, Katsuragi Y, Tokimitsu I. Nutrition, Metabolism & Cardiovascular Diseases 2008;18:408-414.