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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.
Up to 3.5 g dried leaf per day (Bone 2003).
Up to 7-8 g dried leaves per single dose; not to exceed 30 g dried leaves per day (EMA 2012).
Directions for use:
Add dried leaves to 150 ml of boiling water. Allow to steep for 30 minutes. Strain before drinking.
Up to 500 mg extract per day (up to 3.5 g dried leaves per day) (Perrinjaquet-Moccetti et al. 2008).
Up to 20.8% oleuropein (Perrinjaquet-Moccetti et al. 2008).
0.6 — 3.5 g dried leaves per day (EMA 2012; Bone 2003).
Directions for use:
Add dried or fresh leaves to 150 ml of boiling water. Allow to simmer to reach 100 ml. Strain before drinking. To be consumed hot (morning and evening) (EMA 2012).
7 — 8 g dried leaves per single dose; not to exceed 30 g dried leaves per day (EMA 2012).
Directions for use:
Add dried leaves to 150 ml of boiling water. Allow to steep for 30 minutes. Strain and consume.
Directions for use:
Take with food (Bone 2003).
For occasional use only (APhA 2002; CPhA 2002).
Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.
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de Bock M, Derraik JGB, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, Hofman PL, Cutfield WS. Olive (Olea europaea a L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PLoS ONE 8(3):e57622. doi: 10.1371/journal.pone.0057622
EMA 2012: European Medicines Agency. Community herbal monograph on Olea europaea L., folium. [Accessed 2014 April 1].
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Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B, Aydogan, C. Food Supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytotherapy Research 2008;22(9):1239-1242.
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EFSA 2011: European Food Safety Authority. Scientific Opinion on the substantiation of health claims related to polyphenols in olive and protection of LDL particles from oxidative damage (ID 1333, 1638, 1639, 1696, 2865), maintenance of normal blood HDL-cholesterol concentrations (ID 1639), maintenance of normal blood pressure (ID 3781), "anti-inflammatory properties" (ID 1882), "contributes to the upper respiratory tract health" (ID 3468), "can help to maintain a normal function of gastrointestinal tract" (3779), and "contributes to body defences against external agents" (ID 3467) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), European Food Safety Authority (EFSA), Parma, Italy. [Accessed 2014 July 9].
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