CURCUMIN

Help on accessing alternative formats, such as Portable Document Format (PDF), Microsoft Word and PowerPoint (PPT) files, can be obtained in the alternate format help section.

This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.

Notes

Date

August 28, 2018

Proper name(s), Common name(s), Source material(s)

Table 1. Proper name(s), Common name(s), Source material(s)
Proper name(s) Common name(s) Source material(s)
Proper name(s) Part(s)
(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

Curcumin

Curcuma longa Rhizome

References: Proper name: O'Neil et al. 2018; Common name: Goel et al. 2008, Boon and Smith 2004, Deodhar et al. 1980; Source materials: Goel et al. 2008, Boon and Smith 2004, Deodhar et al. 1980.

Route of Administration

Oral

Dosage Form(s)

This monograph excludes foods or food-like dosage forms as indicated in the Compendium of Monographs Guidance Document.

Acceptable dosage forms for the age category listed in this monograph and specified route of administration are indicated in the Compendium of Monographs Guidance Document.

Use(s) or Purpose(s)

Dose(s)

Subpopulation(s)

Adults 18 years and older

Quantity(ies)

Antioxidant

Not to exceed 1200 milligrams curcumin per day and 400 milligrams per single dose (Deodhar et al. 1980).

Relief of joint inflammation

1200 milligrams curcumin, per day; Not to exceed 400 milligrams per single dose (Boon and Smith 2004; Deodhar et al. 1980).

Direction(s) for use

No statement required.

Duration(s) of Use

No statement required.

Risk Information

Caution(s) and warning(s)

All products

Relief of joint inflammation

Consult a health care practitioner/health care provider/health care professional/doctor/physician if symptoms persist or worsen.

Contraindication(s)

No statement required.

Known adverse reaction(s)

No statement required.

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage conditions

No statement required.

Specifications

References Cited

Blumenthal M, Goldberg A, Brinkmann J, editors. 2000. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications.

Boon H, Smith M. 2004. The Complete Natural Medicine Guide to the 50 Most Common Medicinal Herbs. Toronto (ON): Robert Rose Inc

Brinker F. Herb Contraindications and Drug Interactions, 4th edition. Sandy (OR): Eclectic Medical Publications; 2010.

Deodhar SD, Sethi R, Srimal RC. 1980. Preliminary studies on antirheumatic activity of curcumin (di-feruloyl methane). Indian Journal of Medical Research 71:632-634.

ESCOP 2003: ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products, 2nd edition. 2003. Exeter (GB): European Scientific Cooperative on Phytotherapy and Thieme.

Goel A, Kunnumakkara AB, Aggarwal BB. 2008. Curcumin as "Curecumin": From kitchen to clinic. Biochemical Pharmacology 75:787-809.

McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. 2000. Herbs of Commerce, 2nd edition. Silver Spring (MD): American Herbal Products Association.

Mills S, Bone K. 2000. Principles and Practice of Phytotherapy. Toronto (ON): Churchill Livingstone.

O'Neil MJ, Heckelman PE, Koch CB, Roman KJ, editors. 2018. The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 14th edition. Electronic version [online].Whitehouse Station (NJ): Merck & Co., Inc. [Accessed 2018 June 14]. Available at:Next link will take you to another Web site  http://www.medicinescomplete.com/mc/merck/current/monographs.htm

References Reviewed

Araújo CA, Leon LL. 2001. Abstract: Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz 96(5):723-728.

Felter HW. 1983. The Eclectic Materia Medica, Pharmacology and Therapeutics. Sandy (OR): Eclectic Medical Publications [Reprint of 1922 original].

Felter HW, Lloyd JU. 1983. King's American Dispensatory, Volume 2, 18th edition. Sandy (OR): Eclectic Medical Publications [Reprint of 1898 original].

Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Sólyom AM, Timmermann BN.

2006. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. Journal of Natural Products 69(3):351-355.

Gerard J. 1975. The Herbal or General History of Plants. The Complete 1633 Edition as Revised and Enlarged by Thomas Johnson. NY (NY): Dover Publications.

Grieve M. 1971. A Modern Herbal, Volume 2. New York (NY): Dover Publications [Reprint of 1931 Harcourt, Brace & Company publication].

Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. 2008. curcumin: From ancient medicine to current clinical trials. Cellular and Molecular Life Sciences 65:1631-1652

Hoffmann D. 2003. Medical Herbalism: The Science and Practice of Herbal Medicine. Rochester (VT): Healing Arts Press.

Jurenka JS. 2009. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Alternative Medicine Review 14(2):141-153.

Khory RN, Katrak NN. 1999. Materia Medica of India and their Therapeutics. Delhi (IN): Komal Prakashan.

Kiso Y, Suzuki Y, Watanabe N, Oshima Y, Hikino H. 1983. Antihepatotoxic principles of Curcuma longa rhizomes. Journal of Medicinal Plant Research 49:185-187.

Kohli K, Ali J, Ansari J, Raheman Z. 2005. Curcumin: a natural antiinflammatory agent. Indian Journal of Pharmacology 37(3):141-147.

Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. 1991. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. Journal of Ethnopharmacology 33:91-95.

Mills S. 1985. The Dictionary of Modern Herbalsim. Wellingborough (GB): Thorsons Publishers Ltd.

Moerman DE. 1998. Native American Ethnobotany. Portland (OR): Timber Press.

Rivera-Espinoza Y, Muriel P. 2009. Pharmacological actions of curcumin in liver diseases or damage. Liver International 29(10):1457-1466.

Satoskar RR, Shah SJ, Shenoy SG. 1986. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. International Journal of Clinical Pharmacology, Therapy and Toxicology 24(12):651-654.

Srimal R, Dhawan B. 1973. Pharmacology of diferuloyl methane (curcumin), a non-sterodal antiinflammatory agent. Journal of Pharmacy and Pharmacology 25:447-452.