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Drugs and Health Products

Citrus Bioflavonoids (Under Consultation)

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.

Notes
  • Text in parentheses is additional optional information which can be included on the PLA and product label at the applicant's discretion.
  • The solidus (/) indicates that the terms and/or the statements are synonymous. Either term or statement may be selected by the applicant.

Date

February 7, 2014

Proper name(s)

Citrus Bioflavonoids (Burdock 2005)

Common name(s)

Citrus Bioflavonoids (Burdock 2005)

Source material(s)

  • Citrus sinensis (L.) Osbeck –; Peel, rind and/or fruit (Nogata et al. 2006; USDA 2006; Burdock 2005)
  • Citrus limon (L.) Burm.f. –; Peel, rind and/or fruit (USDA 2011; Nogata et al. 2006; Burdock 2005)
  • Citrus reticulata Blanco –; Peel, rind and/or fruit (Nogata et al. 2006; Burdock 2005; USDA 1994)
  • Citrus aurantiifolia (Christm.) Swingle –; Peel, rind and/or fruit (USDA 2013a; Nogata et al. 2006; Burdock 2005)
  • Citrus paradis Macfad. Peel, rind and/or fruit (Nogata et al. 2006; USDA 2006b)

Route(s) of administration

Oral

Dosage form(s)

  • The acceptable pharmaceutical dosage forms include, but are not limited to capsules, chewables (e.g. gummies, tablets), liquids, powders, strips or tablets.
  • This monograph is not intended to include foods or food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s)

Statement(s) to the effect of:

Provides antioxidants (Jung et al. 2003; Manthey et al. 2001).

Dose(s)

Subpopulation(s)

Adults (≥ 18 years)

Quantity(ies)

Up to 1000 mg citrus bioflavonoids, per day (USDA 2013b; Chun et al. 2007; Burbock et al. 2005; Blostein-Fujii et al. 1999).

Note
Must not exceed 1000 mg citrus bioflavonoids, per day, when combined with other bioflavonoids such as but not limited to, quercetin, hesperidin, rutin, etc.

Duration of use

No statement required.

Risk Information

Statement(s) to the effect of:

Caution(s) and warning(s)

Products providing ≥ 50 mg per day:
If you are taking prescription medication, consult a healthcare practitioner prior to use as citrus bioflavonoids may alter the effectiveness of these medications (Brinker 2010).

Contraindication(s)

No statement required.

Known adverse reaction(s)

No statement required.

Non-medicinal Ingredients

Must be chosen from the current NNHPD Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage conditions

No statement required.

Specifications

References cited

  • Blostein-Fujii A, DiSilvestro RA, Frid D, Katz C. Short term citrus flavonoid supplementation of type II diabetic women: no effect on lipoprotein oxidation tendencies. Free Radical Research 1999;30(4):315-320.
  • Brinker 2010: Brinker F.Le lien suivant vous amène à un autre site Web  Final updates and additions for Herb Contraindications and Drug Interactions, 3rd edition, including extensive Appendices addressing common problematic conditions, medications and nutritional supplements, and influences on Phase I, II & III metabolism with new appendix on botanicals as complementary adjuncts with drugs.Sandy (OR): Eclectic Medical Publications. [Updated July 13, 2010; Accessed 2013 August 06].
  • Burdock G.A. Fenaroli's Handbook of Flavor Ingredients, 5th ed. CRC Press; 2005.
  • Chun OK, Chung SJ, Song WO. Estimated dietary flavonoid intake and major food sources of U.S. adults. Journal of Nutrition 2007;137(5):1244-1252.
  • Jung UJ, Kim HJ, Lee JS, Lee MK, Kim HO, Park EJ, Kim HK, Jeong TS, Choi MS. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. Clinical Nutrition 2003;22(6):561-568.
  • Manthey JA, Guthrie N, Grohmann K. Biological Properties of Citrus Flavonoids Pertaining to Cancer and Inflmmation. Current Medicinal Chemistry 2001;8(2):135-153.
  • Nogata Y, Sakamoto K, Shiratsuchi H, Ishii T, Yano M, Ohta H. Flavonoid composition of fruit tissues of citrus species. Bioscience Biotechnology and Biochemistry 2006;70(1):178-192.
  • USDA 1994: United States Department of Agriculture, Agricultural Research Service, National Genetic Resources Program.Le lien suivant vous amène à un autre site Web  Germplasm Resources Information Network (GRIN).National Germplasm Resources Laboratory, Beltsville (MD). [Citrus reticulata Blanco; Last updated 1994 August 23; Accessed 2013 August 12].
  • USDA 2006a: United States Department of Agriculture, Agricultural Research Service, National Genetic Resources Program.Le lien suivant vous amène à un autre site Web  Germplasm Resources Information Network (GRIN).National Germplasm Resources Laboratory, Beltsville (MD). [Citrus sinensis (L.) Osbeck; Last updated 2006 October 17; Accessed 2013 August 12].
  • USDA 2006b: United States Department of Agriculture, Agricultural Research Service, National Genetic Resources Program. Germplasm Resources Information Network (GRIN).National Germplasm Resources Laboratory, Beltsville (MD). [Citrus paradisi Macfad.; Last updated 2006 October 17; Accessed 2014 January 10].
  • USDA 2011: United States Department of Agriculture, Agricultural Research Service, National Genetic Resources Program.Le lien suivant vous amène à un autre site Web  Germplasm Resources Information Network (GRIN).National Germplasm Resources Laboratory, Beltsville (MD). [Citrus limon (L.) Burm.f.; Last updated 2011 July 19; Accessed 2013 August 12].
  • USDA 2013a: United States Department of Agriculture, Agricultural Research Service, National Genetic Resources Program.Le lien suivant vous amène à un autre site Web  Germplasm Resources Information Network (GRIN).National Germplasm Resources Laboratory, Beltsville (MD). [Citrus aurantiifolia (Christm.) Swingle. Last updated 2013 May 21; Accessed 2013 August 12].
  • USDA 2013b.Le lien suivant vous amène à un autre site Web  USDA Database for selected Flavonoid Content of Selected Foods. Release 3.1.Prepared by S Bhagwat, DB Haytowitz, JM Holden. Nutrient Data Laboratory, Betsville Human Nutrition Research Center, Agriculture Research Service, U.S. Department or Agriculture; June 2013. [Accessed 2013 August 13].

References reviewed