CHONDROITIN SULFATE

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.

Notes

Date

July 1, 2019

Proper name(s), Common name(s), Source material(s)

Table 1. Proper name(s), Common name(s), Source material(s)
Proper name(s) Common name(s) Source ingredient(s) Source material(s)
Common name(s) Proper name(s) Part(s)1

Chondroitin sulfate

Chondroitin sulfate

Sodium chondroitin sulfate

  • Anas platyrhynchos
  • Anser anser
  • Bos taurus
  • Cygnus olor
  • Dromaius novaehollandiae
  • Gallus gallus
  • Meleagris gallopavo
  • Numida meleagris
  • Rhea Americana
  • Struthio camelus
  • Sus scrofa

Cartilage

References: Proper name: O'Neil et al. 2006; Common name: O'Neil et al. 2006; Source information: NIH 2019, USP 31 2008.

1 Cartilage must be derived from healthy and domestic animals used for food by humans (USP 31 2008).

Route of Administration

Oral

Dosage Form(s)

This monograph excludes foods or food-like dosage forms as indicated in the Compendium of Monographs Guidance Document.

Acceptable dosage forms for any age category listed in this monograph for the specified route of administration are listed in the Compendium of Monographs Guidance Document.

Use(s) or Purpose(s)

Helps to relieve (joint) pain associated with osteoarthritis (of the knee) (Mazières et al. 2007; Uebelhart et al. 2004; Mazières et al. 2001; Bourgeois et al. 1998; Bucsi and Poor 1998; Uebelhart et al. 1998).

Dose(s)

Subpopulation(s)

Adults 18 years and older

Quantity(ies)

800 - 1,200 milligrams of Chondroitin sulfate, per day (Mazières et al. 2007; Hathcock and Shao 2006; Uebelhart et al. 2004; Mazières et al. 2001; Bourgeois et al. 1998; Bucsi and Poor 1998; Uebelhart et al. 1998)

Direction(s) for use

No statement required.

Duration(s) of Use

Use for at least 3 months to see beneficial effects (Bjordal et al. 2007).

Risk Information

Caution(s) and warning(s)

Contraindication(s)

No statement required.

Known adverse reaction(s)

No statement required.

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage conditions

No statement required.

Specifications

References Cited

References Reviewed