CAYENNE - CAPSICUM ANNUUM

Oral

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.

Notes

• Text in parentheses is additional optional information which can be included on the PLA and product label at the applicant's discretion.
• The solidus (/) indicates that the terms and/or statements are synonymous. Either term or statement may be selected by the applicant.

Date

October 30, 2018

Proper name(s), Common name(s), Source material(s)

Table 1. Proper name(s), Common name(s), Source material(s)

Proper name(s)	Common name(s)	Source material(s)
		Proper name(s)	Part(s)	Preparation(s)
Capsicum annuum	Cayenne Cayenne pepper Chili pepper Paprika Red Pepper	Capsicum annuum	Fruit	Dried

References: Proper name: USDA 2018; Common names: Blumenthal et al. 2000, McGuffin et al. 2000; Source material: Bradley 2006, Felter and Lloyd 1983.

Route of Administration

Oral

Dosage Form(s)

This monograph excludes foods or food-like dosage forms as indicated in the Compendium of Monographs Guidance Document.

Acceptable dosage forms for the age category listed in this monograph and specified route of administration are indicated in the Compendium of Monographs Guidance Document.

Use(s) or Purpose(s)

• Traditionally used in Herbal Medicine to aid digestion (Bradley 2006; Ellingwood 1983; Felter and Lloyd 1983).
• Traditionally used in Herbal Medicine to help support peripheral circulation (Bradley 2006; Ellingwood 1983; Wren 1907).

Note

Claims for traditional use must include the term "Herbal Medicine", "Traditional Chinese Medicine", or "Ayurveda".

Dose(s)

Subpopulation(s)

Adults 18 years and older

Quantity(ies)

Methods of preparation: Dry, Powder, Non-Standardised Extracts (Dry extract, Tincture, Fluid extract, Decoction, Infusion)

15-650 milligrams of dried fruit, per day (Bradley 2006; Blumenthal 2003; Hoffmann 2003; Lust 1987; Felter and Lloyd 1983; Grieve 1971)

Direction(s) for use

No statement required.

Duration(s) of Use

No statement required.

Risk Information

Caution(s) and warning(s)

• Keep out of the reach of children.
• Call a Poison Control Center immediately if overdose or accidental ingestion occurs (CPS 2008).
• Consult a health care practitioner/health care provider/health care professional/doctor/ physician if symptoms persist or worsen.
• Consult a health care practitioner/health care provider/health care professional/doctor/ physician prior to use if you are pregnant, breastfeeding, or have stomach ulcers or inflammation (Brinker 2010; Bradley 2006; Boon and Smith 2004).

Contraindication(s)

No statement required.

Known adverse reaction(s)

No statement required.

Non-medicinal ingredients

Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage conditions

No statement required.

Specifications

• The finished product specifications must be established in accordance with the requirements described in the Natural and Non-prescription Health Products Directorate (NNHPD) Quality of Natural Health Products Guide.
• The medicinal ingredient must comply with the requirements outlined in the NHPID.

References Cited

• Blumenthal M. ABC Clinical Guide to Herbs. New York (NY): Theime; 2003.
• Blumenthal M, Goldberg A, Brinkmann J, editors. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
• Boon H, Smith MJ. The Complete Natural Medicine Guide to the 50 Most Common Medicinal Herbs, 2^nd edition. Toronto (ON): Robert Rose Inc; 2004.
• Bradley PR, editor. British Herbal Compendium: A Handbook of Scientific Information on Widely Used Plant Drugs, Volume 2. Bournemouth (GB): British Herbal Medicine Association; 2006.
• Brinker F. Herb Contraindications and Drug Interactions, 4th edition. Sandy (OR): Eclectic Medical Publications; 2010.
• CPS 2008: Repchinksy C, Welbanks L, Bhalla A, Fortin K, Jarvis B, Jovaisas B, Acharya S. Compendium of Pharmaceutical Specialties. Ottawa (ON): Canadian Pharmacists Association; 2008.
• Ellingwood F. American Materia Medica, Therapeutics and Pharmacognosy. Sandy (OR): Eclectic Medical Publications; 1983 [Reprint of 1919 original].
• Felter HW, Lloyd JU. King's American Dispensatory, Volume 1, 18^th edition. Sandy (OR): Eclectic Medical Publications; 1983 [Reprint of 1898 original].
• Grieve M. A Modern Herbal, Volume 1. New York (NY): Dover Publications; 1971 [Reprint of 1931 Harcourt, Brace & Company publication].
• Hoffman D. Medical Herbalism: The Science and Practice of Herbal Medicine. Rochester (VT): Healing Arts Press; 2003.
• Lust J. The Herb Book. New York (NY): Bantam Books Incorporated, published by arrangement with Benedict Lust Publications; 1987.
• McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. Herbs of Commerce, 2^nd edition. Silver Spring (MD): American Herbal Products Association; 2000.
• USDA 2018: United States Department of Agriculture, Agricultural Research Service, National Genetic Resources Program. Germplasm Resources Information Network (GRIN). Capsicum Annuum. National Germplasm Resources Laboratory, Beltsville (MD). [Accessed 2018 August 15]. Available at: http://www.ars-grin.gov/cgi-bin/npgs/html/tax_search.pl
• Wren RC. Potter's Cyclopedia of Botanical Drugs and Preparations. London (GB): Potter and Clark; 1907.

References Reviewed

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• Bernstein JE, Bickers DR, Dahl MY, Roshal JY. Treatment of chronic post-herpetic neuralgia with topical capsaicin. A preliminary study. Journal of the American Academy of Dermatology 1987;17(1):93-96.
• Bortolotti M, Coccia G, Grossi G, Miglioli M. Treatment of functional dyspepsia with red pepper. Alimentary Pharmacology and Therapeutics 2002;16(6):1075-1082.
• Charkoudian N, Fromy B, Saumet JL. Reflex control of the cutaneous circulation after acute and chronic local capsaicin. Journal of applied physiology 2001;90(5):1860-1864.
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• Desai HG, Venugopalan K, Anita FP. Effect of red chilli powder on the DNA content of gastric aspirates. Gut 1973;14:974-976.
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• Schnitzer TJ, Morton C, Coker S, Flynn P. Effectiveness of reduced applications of topical capsaicin (0.025%) cream in osteoarthritis. Arthritis and Rheumatism 1992;35:S132.
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• Van der Schueren BJ, de Hoon JN, Vanmolkot FH, Van Hecken A, Depre M, Kane SA, De Lepeleire I, Sinclair SR. Reproducibility of the capsaicin-induced dermal blood flow response as assessed by laser Doppler perfusion imaging. British Journal of Clinical Pharmacology 2007;64(5):580-590.
• Visudhiphan S, Poolsuppasit S, Piboonnukarintr O, Tumliang S. The relationship between high fibrinolytic activity and daily capsicum ingestion in Thais. American Journal of Clinical Nutrition 1982;35(6):1452-1458.
• Wang DH. The vanilloid receptor and hypertension. Acta Pharmacologica Sinica 2005;26(3):286-294.
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• Willams SR, Clark RF, Dunford JV. Contact dermatitis associated with capsaicin: Human hand syndrome. Annals of Emergency Medicine 1995;25(5):713-715.
• Yoshioka M, St-Pierre S, Drapeau V, Dionne I, Doucer E, Suzuki M, Tremblay A. Effects of red pepper on appetite and energy intake. British Journal of Nutrition 1999;82(2):115-123.