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Drugs and Health Products

Antioxidants

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This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient.

Notes
  • Text in parentheses is additional optional information which can be included on the PLA and product label at the applicant's discretion.
  • The solidus (/) indicates that the terms and/or the statements are synonymous. Either term or statement may be selected by the applicant.
  • When "Fruit" is indicated as source material, it only includes the parts of the fruit that are consumed historically as human food.

Date:

August 1, 2017

Medicinal Ingredients:

Refer to Appendices 1, 2, 3 and 4.

Proper name(s), common name(s), source material(s), dose(s):

Refer to Appendices 1, 2, 3 and 4.

Route(s) of administration:

Oral

Dosage form(s):

  • The acceptable pharmaceutical dosage forms include, but are not limited to capsules, chewables (e.g. gummies, tablets), liquids, powders, strips or tablets.
  • This monograph is not intended to include foods or food-like dosage forms such as bars, chewing gums or beverages.

Use(s) or Purpose(s):

All products (must include at least one of the antioxidant claims below)

  • Source of antioxidant(s)/Provides antioxidant(s).
  • Source of antioxidant(s)/Provides antioxidant(s) that help(s) fight/protect (cell) against/reduce (the oxidative effect of/the oxidative damage caused by/cell damage caused by) free radicals.

Additional Claims:

For Vitamins, Minerals and/or medicinal ingredients standardized to Vitamins and/or Minerals:

As per the Natural and Non-Prescription Health Products Directorate (NNHPD) Multi-Vitamin/Mineral Supplements Monograph.

Note: For standardized medicinal ingredients, the potency information must be indicated on the ePLA form and label and meet the minimum monographed daily dose to support vitamin/mineral claim.

Additional Claims:

For marigold extracts, lutein, lutein esters, zeaxanthin, and zeaxanthin esters:

As per the NNHPD Marigold Extract and Isolates (Lutein and Zeaxanthin) Monograph.

Dose(s):

Subpopulation:

Adults (≥ 18 years)

Quantities:

Refer to Appendices 1, 2, 3 and 4.

Note:

Potency Information (Optional):

The Medicinal Ingredients (MI) supported by this monograph could be standardized to any of the following constituents if they are naturally occurring in the MI and if the Quantity Crude Equivalent (QCE) of the MI does not exceed the Maximum Daily Dose indicated on this monograph or on the referenced NNHPD monographs. Note that QCE is mandatory on the PLA form and label for standardized extracts as safety is established based on the QCE.

Anthocyanidins
Anthocyanins
Anthocyanosides
Bioflavonoids
Catechins
Citrus bioflavonoids (refer to the NNHPD Citrus bioflavonoids monograph for maximum daily dose and risk statements) Epigallocatechin 3-gallate (EGCG)
Ellagic acid
Hesperidin
Lutein (refer to the NNHPD Marigold Extract and Isolates (Lutein and Zeaxanthin) monograph for maximum daily dose and risk statements)
Lycopene (refer to the NNHPD Lycopene monograph for maximum daily dose)
Mixed carotenoids
Oligomeric proanthocyanidins
Polyphenols
Polysaccharides
Proanthocyanidins
Procyanidins
Punicalagin
Quercetin (refer to the NNHPD quercetin monograph for maximum daily dose and risk statements)
Resveratrol (refer to the NNHPD resveratrol monograph for maximum daily dose and risk statements)
Rutin (refer to the NNHPD rutin monograph for maximum daily dose and risk statements)
Tannins
Tocopherols
Tocotrienols
Vitamin(s) and mineral(s) supported by the NNHPD Multi-Vitamin/Mineral Supplements monograph (refer to the NNHPD monograph for maximum daily dose and risk statements).
Zeaxanthin (refer to the NNHPD Marigold Extract and Isolates (Lutein and Zeaxanthin) monograph for maximum daily dose and risk statements).

Directions for use:

For medicinal ingredients associated with another NNHPD monograph, direction of use statements indicated in those monographs must be included on the PLA and label.

Ingredient Combinations:

All ingredients included in this monograph may be combined together with the following restrictions:

  • Products containing iodine, algae or other source of iodine must not provide more than 800 micrograms of iodine per day for adults.
  • The maximum daily dose for beta-carotene (including beta-carotene from mixed carotenoids) in combination with other vitamin A source materials must not exceed the maximum daily dose for vitamin A indicated on the NNHPD Vitamin A monograph.
  • When the ingredient "Mixed tocopherol concentrate" is combined with Vitamin E, the total daily dose of alpha-tocopherol must be taken into consideration. If it exceeds 179 mg per day, risk statements from the NNHPD single monograph for vitamin E must be included on the PLA.
  • The total daily doses of vitamins and minerals in the finished product must not exceed quantities listed in the NNHPD Multi-Vitamin/Mineral Supplements Monograph.
  • For products providing bioflavonoids (citrus bioflavonoids, quercetin, hesperidin, rutin), the total daily dose must not exceed 1 g per day.
  • For products containing a combination of green tea extract, green coffee bean extract and/or other sources of caffeine, the total amount of caffeine must not exceed 150 mg per day.

Duration of use:

For medicinal ingredients associated with another NNHPD monograph, duration of use statements indicated in those monographs must be included on the PLA and label.

Astaxanthin > 4 mg per day:
For use beyond 3 months, consult a health care practitioner (EFSA 2014).

Risk information:

For medicinal ingredients associated with another NNHPD monograph, risk statements indicated in those monographs must be included on the PLA and label.

For other medicinal ingredients, consult Table 1 for appropriate statements related to each medicinal ingredient. The medicinal ingredients in Table 1 are associated with the required numbered statements below.

Caution(s) and warning(s):

1.  If you are pregnant or breastfeeding, consult a health care practitioner prior to use.
2.  If you are taking any prescription medication, consult a health care practitioner prior to use (Brinker 2010).

Contraindication(s):

3.  If you are pregnant or breastfeeding, do not use (Brinker 2010).

Known adverse reaction(s):

No statement required
Table 1 Risk information
Medicinal Ingredient Risk Information
Astaxanthin 1
Hesperidin (> 50 mg/day) 1 and 2
Squalene 1
L-Glutathione 1
Aphanizomenon flos-aquae 3
Cannabis sativa seed 3
Citrus paradisi fruit 2
Berberis vulgaris fruit 3
Lycium barbarum fruit 1
Chlorophyll 1
Fructooligosaccharides Apply the risk statements from NNHPD Inulin Monograph
Chlorophyllin copper complex 1

Non-medicinal ingredients:

Must be chosen from the current Natural Health Products Ingredients Database (NHPID) and must meet the limitations outlined in the database.

Storage conditions:

For medicinal ingredients associated with another NNHPD monograph, storage conditions statements indicated in those monographs must be included.

Specifications:

  • The finished product specifications must be established in accordance with the requirements described in the NNHPD Quality of Natural Health Products Guide..
  • The medicinal ingredient must comply with the requirements outlined in the NHPID.
  • For medicinal ingredients associated with another NNHPD monograph, specifications indicated in those monographs apply.

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  • Walsh DE, Yaghoubian V, Behforooz A. Effect of glucomannan on obese patients: a clinical study. International Journal of Obesity 1984;8(4):289-293.
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  • Wasantwisut E, Viriyapanich T. Ivy Gourd (Coccinia grandis Voigt, Coccinia cordifolia, Coccinia indica) in human nutrition and traditional applications. Plants in Human Health and Nutrition Policy 2003;9:60-66.
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Appendix 1:

For the following medicinal ingredients consult the respective NNHPD single ingredient/product monograph for information on the source material(s), direction of use statement(s), duration of use statement(s) and risk statement(s). Note that only the antioxidant claim from these monographs can be made.

Proper name(s) Common name(s) Source material(s)
Antioxidant Claim(s)
Direction of use statement(s)
Duration of use statement(s)
Risk statement(s)
  • (±)-1,2-Dithiolane-3-pentanoic acid
  • DL-alpha Lipoic acid
  • DL-alpha Lipoic acid
  • DL-Thioctic Acid
As per NNHPD Alpha lipoic acid, DL- monograph
(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Curcumin As per NNHPD Curcumin monograph
  • 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
  • 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
  • 3,3',4',5,7-pentahydroxyflavone
Quercetin As per NNHPD Quercetin monograph
2,5-Cyclohexadiene-1,4-dione, 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl]-5,6-dimethoxy-3-methyl
  • Coenzyme Q10
  • CoQ10
  • Ubidecarenone
  • Ubiquinone-10
As per NNHPD Coenzyme Q10 monograph
  • 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 3-(O-6-deoxy-alpha-l-mannopyranosyl-(1-6)-beta-d-glucopyranosyloxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
  • Quercetin-3-rutinoside
  • Rutin
  • Rutoside
As per NNHPD Rutin monograph
  • (L-3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide, inner salt (R)-3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt
  • L-Carnitine
  • L-Carnitine
  • Levocarnitin
As per NNHPD L-Carnitine monograph
(3R,3'R,6'R)-beta,epsilon-Carotene-3,3'-diol Lutein As per NNHPD Marigold Extract and Isolates (Lutein and Zeaxanthin) monograph
(3R,3'R)-beta,beta-carotene-3,3'-diol Zeaxanthin As per NNHPD Marigold Extract and Isolates (Lutein and Zeaxanthin) monograph
Active hexose correlated compound
  • Active hexose correlated compound
  • AHCC
As per NNHPD Active hexose correlated compound - Granule (AHCC-FG) monograph
and/or
NNHPD Active hexose correlated compound - Powder (AHCC-FD) monograph
Aloe vera
  • Aloe vera
  • Aloe
  • Barbados aloe
  • Curaçao aloe
As per NNHPD Aloe vera Leaf Gel - Oral monograph
Arthrospira platensis Spirulina As per NNHPD Spirulina monograph
Ascophyllum nodosum Norwegian Kelp As per NNHPD Kelp products monograph
Camellia sinensis
  • Green tea extract
  • Camellia sinensis extract
  • Thea sinensis extract
As per NNHPD Green Tea Extract monograph
Chlorella vulgaris Chlorella As per NNHPD Chlorella - Cholrella vulgaris monograph
  • Cinnamomum aromaticum
  • Cinnamomum cassia
  • Cassia
  • Cassia cinnamon
  • Chinese cinnamon
  • Rou Gui
As per NNHPD Cassia cinnamon - Cinnamomum aromaticum monograph
Cinnamomum verum
  • Ceylon cinnamon
  • Cinnamon
  • True cinnamon
  • Tvak
As per NNHPD Cinnamon - Cinnamomum verum monograph
Citrus Bioflavonoids Citrus bioflavonoids As per NNHPD Citrus Bioflavonoids monograph
Cocos nucifera Coconut oil As per NNHPD Multiple Ingredient Fixed Oil Products - Oral monograph
  • Coffea arabica
  • Coffea canephora
Green coffee bean extract As per NNHPD Green Coffee Bean Extract monograph
Curcuma longa Turmeric As per NNHPD Turmeric - Oral monograph
Euterpe oleracea
  • Acai
  • Açai
  • Assai palm
  • Cabbage palm
As per NNHPD Acai - Euterpe oleracea monograph
Fucus vesiculosus
  • Bladder fucus
  • Kelpware
  • Seawrack
As per NNHPD Kelp products monograph
Ganoderma lucidum
  • Reishi
  • Ganoderma
  • Ling zhi
As per NNHPD Reishi - Ganoderma lucidium monograph
Hericium erinaceus Lion's Mane As per NNHPD Mushrooms monograph
Irvingia gabonensis African wild mango As per NNHPD African Wild Mango - Irvingia gabonensis monograph
Laminaria digitata Kelp As per NNHPD Kelp products monograph
Laminaria japonica
  • Japanese kelp
  • Makombu
As per NNHPD Kelp products monograph
Lentinula edodes Shiitake As per NNHPD Mushrooms monograph
Lepidium meyenii
  • Maca
  • Peruvian-ginseng
As per NNHPD Maca - Lepidium meyeni monograph
Linum usitatissimum
  • Flax
  • Flaxseed
  • Linseed
As per NNHPD Flaxseed monograph
Lutein esters Lutein esters As per NNHPD Marigold Extract and Isolates (Lutein and Zeaxanthin) monograph
  • (all-trans)-Lycopene
  • psi,psi-Carotene
Lycopene As per NNHPD Lycopene monograph
  • N-Acetyl-L-Cysteine
  • L-alpha-Acetamido-beta-mercaptopropionic acid
N-Acetyl-L-Cysteine As per NNHPD N-Acetyl-L-Cysteine monograph
  • Ocimum sanctum
  • Ocimum tenuiflorum
  • Holy basil
  • Sacred basil
  • Tulsi
As per NNHPD Holy Basil - Ocimum Tenuliflorun - Leaf monograph
Olea europaea Olive oil As per NNHPD Multiple Ingredient Fixed Oil Products - Oral monograph
Ophiocordyceps sinensis
  • Dong chong xia cao
  • Cordyceps
  • Chinese Caterpillar Fungus
  • Cordyceps sinensis
As per NNHPD Mushrooms monograph
Paecilomyces hepiali
  • Fa xiao chong cao jun fen
  • Cordyceps
  • Cultured Chinese Caterpillar Fungus Powder
As per NNHPD Mushrooms monograph
Propolis
  • Bee propolis
  • Propolis
  • Propolis resin
As per NNHPD Propolis - Oral monograph
Punica granatum Pomegranate As per NNHPD Pomegranate monograph
Rhodiola rosea
  • Rhodiola
  • Roseroot
As per NNHPD Rhodiola - Rhodiola rosea monograph
Royal Jelly Royal Jelly As per NNHPD Royal Jelly monograph
Salvia officinalis
  • Sage
  • Common sage
  • Dalmation sage
  • Garden sage
As per NNHPD Sage - Salvia officinalis - Oral monograph
Sambucus nigra subsp. nigra
  • European elder
  • Black elder
As per NNHPD Elder - Sambucus monograph
Sambusus nigra subsp. canadensis
  • American elder
  • Canadian elder
Selenium Selenium As per NNHPD Multi-vitamin/mineral supplements monograph
Solanum lycopersicum Tomato extract As per NNHPD Tomato extract monograph
Tagetes erecta Marigold extract As per NNHPD Marigold Extract and Isolates (Lutein and Zeaxanthin) monograph
  • Trans-Resveratrol
  • (E)-5-(p-Hydroxystyryl)resorcinol
  • 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
Resveratrol As per NNHPD Resveratrol monograph
Triticum aestivum Wheat germ oil As per NNHPD Multiple Ingredient Fixed Oil Products - Oral monograph
Ubiquinol Ubiquinol As per NNHPD Ubiquinol monograph
  • Vaccinium corymbosum
  • Vaccinium angustifolium
  • Vaccinium pallidum
Blueberry As per NNHPD Blueberry monograph
Vaccinium macrocarpon
  • American cranberry
  • Cranberry
  • Large cranberry
As per NNHPD Cranberry monograph
Vaccinium macrocarpon Dried Cranberry Juice As per NNHPD Cranberry juice, dried monograph
Vaccinium myrtillus Bilberry As per NNHPD Bilberry - Oral monograph
Vitamin C
  • Ascorbic acid
  • Vitamin C
As per NNHPD Multi-vitamin/mineral supplements monograph
Vitamin E Vitamin E As per NNHPD Multi-vitamin/mineral supplements monograph
Vitis vinifera Grape seed extract As per NNHPD Grape Seed Extract monograph
Vitis vinifera
  • Red Wine Extract
  • Red Wine Polyphenol Extract
As per NNHPD Red Wine Extract monograph
Zeaxanthin esters Zeaxanthin esters As per NNHPD Marigold Extract and Isolates (Lutein and Zeaxanthin) monograph

Appendix 2:

Other Medicinal ingredients - Isolates. Footnote 1
Proper name(s) Common name(s) Source material(s) Maximum daily dose

Table 1 Footnotes

Table 1 Footnote 1

The following references have been consulted:

Gopalan et al. 2014; NNHPD 2013; CNF 2012; Kupcinskas et al. 2008; Andersen et al., 2007; Kanaze et al. 2007; Nielsen et al. 2006; Nogata et al. 2006; Manach et al. 2003; Erlund et al. 2002; Qureshi et al. 2002; Blostein-Fujii et al. 1999; Ameer et al.1996; Miettinen and Vanhanen 1994.

Return to Table 1 footnote 1 referrer

  • 3,3'-dihydroxy-4,4'-diketo-beta-carotene
  • 3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione
Astaxanthin As per NHPID 40 mg
(2S)-7-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one Hesperidin As per NHPID 500 mg
(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene Squalene As per NHPID 1000 mg
  • L-glutathione
  • N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine
L-glutathione As per NHPID 743 mg
Mixed carotenoids Mixed carotenoids As per NHPID 6000 mcg
Mixed tocopherols concentrate Mixed tocopherols concentrate As per NHPID 179 mg
  • Tocotrienol concentrate
  • Tocotrienols
  • Tocotrienol concentrate
  • Tocotrienols
As per NHPID 200 mg

Appendix 3:

Other Medicinal ingredients - Fruits, vegetables, mushrooms, algae and other plants. Footnote 1
Acceptable methods of preparation:
Dry, dry standardized, powder, powder standardized, extract dry, extract dry standardized, extract liquid, extract liquid standardized, fluid extract, fluid extract standardized, tincture, tincture standardized, decoction, decoction standardized, oil fixed, oil fixed standardized.

Proper name(s) Common name(s) Source material(s) Footnote 2 Maximum daily dose

Table 2 Footnotes

Table 2 Footnote 1

The following references have been consulted :

Lim 2015; NNHPD 2015; Zilaee et al. 2014; CNF 2012; Fouladi 2012; Ould Mohamedou et al. 2011; Teas et al. 2011; USDA 2011; Chua et al. 2010; Kumari 2010; Scoglio et al. 2010; Issell et al. 2009; Kimura et al. 2007; Teas et al. 2007; Cherki et al., 2005; Derouiche et al. 2005; Taylor 2005; Callaway 2004; Drissi et al. 2004; Andalla 2003; Beveridge et al. 1999.

Return to Table 2 footnote 1 referrer

Table 2 Footnote 2

When "Fruit" is indicated as source material, it only includes the parts of the fruit that are consumed historically as human food.

Return to Table 2 footnote 2 referrer

Abelmoschus esculentus Okra Fruit 100 g Fresh
10 g Dry
Actinidia chinensis Golden kiwi Fruit 100 g Fresh
15 g Dry
Actinidia deliciosa Kiwi Fruit 100 g Fresh
15 g Dry
Alaria esculenta Kutare
  • Thallus
  • Whole
5 g Dry
Allium ampeloprasum Wild Leek Leaf 100 g Fresh
20 g Dry
Allium cepa Onion Bulb 100 g Fresh
10 g Dry
Allium porrum Leek Leaf 100 g Fresh
20 g Dry
Allium sativum Garlic Bulb As per NNHPD Garlic Monograph
Allium schoenoprasum Chives Leaf 100 g Fresh
10 g Dry
Alpinia galanga Greater galanga Rhizome 100 g Fresh
20 g Dry
Amorphophallus konjac Konjac
  • Root
  • Tuber
60 g Fresh
10 g Dry
Amorphophallus paeoniifolius Elephant yam
  • Root
  • Tuber
100 g Fresh
20 g Dry
Ananas comosus var. comosus Pineapple Fruit 100 g Fresh
15 g Dry
Anethum graveolens Dill Herb top 100 g Fresh
15 g Dry
Aphanizomenon flos-aquae Aphanizomenon flos-aquae Whole 1.8 g Dry
Apium graveolens Celery
  • Herb top
  • Root
  • Tuber
  • Whole plant
100 g Fresh
5 g Dry
Argania spinosa Argan seed oil Seed 15 g of oil
Aristotelia chilensis Maqui Fruit 15 g Dry
Aronia melanocarpa Black chokeberry Fruit 100 g Fresh
15 g Dry
Artemisia dracunculus Tarragon Leaf 2 g Dry
Artemisia vulgaris Mugwort Herb top As per NNHPD St. Mugwort - Oral Monograph
Asparagus officinalis Asparagus Shoot 100 g Fresh
5 g Dry
Avena sativa Oat
  • Seed
  • Seed bran
60 g Cooked
10 g Cooked and Dried
Sprout 20 g Fresh
5 g Dry
Oatgrass
  • Herb top
  • Leaf
20 g Fresh
5 g Dry
Oat oil Seed 15 g of oil
Basella alba Malabar-spinach Leaf 100 g Fresh
10 g Dry
Berberis vulgaris Common barberry Fruit 0.5 g Dry
Bergera koenigii Curryleaf Leaf 2 g Dry
Beta vulgaris Beet
  • Root
  • Tuber
100 g Fresh
10 g Dry
Leaf 100 g Fresh
5 g Dry
Brassica juncea Indian mustard Leaf 100 g Fresh
10 g Dry
Brassica nigra Brown mustard Seed 3 g Dry
Brassica oleracea var. botrytis Cauliflower Herb top 100 g Fresh
10 g Dry
Brassica oleracea var. capitata Cabbage Herb top 100 g Fresh
10 g Dry
Brassica oleracea var. gemmifera Brussels sprouts Bud 100 g Fresh
15 g Dry
Brassica oleracea var. italica Broccoli Herb top 100 g Fresh
10 g Dry
Brassica oleracea var. oleracea Wild cabbage Herb top 100 g Fresh
10 g Dry
Brassica oleracea var. viridis Collard Leaf 100 g Fresh
10 g Dry
Brassica rapa Turnip
  • Root
  • Tuber
100 g Fresh
10 g Dry
Cannabis sativa Hemp Seed 30 g Dry
Capparis spinosa Caper Fruit 100 g Fresh
15 g Dry
Capsicum annuum Cayenne Fruit As per NNHPD Cayenne Monograph
Carica papaya Papaya Fruit 100 g Fresh
10 g Dry
Ceratonia siliqua Carob Fruit 20 g Dry
Chamaemelum nobile Roman chamomile Flower As per NNHPD Chamomile, Roman Monograph
Chenopodium quinoa Quinoa Seed 100 g Cooked
30 g Cooked and Dried
Cicer arietinum Garbanzo Seed 100 g Cooked
40 g Cooked and Dried
Cichorium endivia Escarole Leaf 100 g Fresh
5 g Dry
Cichorium intybus Chicory Root 10 g Fresh
2 g Dry
Leaf 10 g Fresh
1 g Dry
Citrullus lanatus var. lanatus Watermelon Fruit 100 g Fresh
10 g Dry
Citrus aurantiifolia Lime Fruit 100 g Fresh
10 g Dry
Citrus limon Lemon Fruit 100 g Fresh
10 g Dry
Citrus maxima Pomelo Fruit 100 g Fresh
10 g Dry
Citrus paradisi Grapefruit Fruit 100 g Fresh
10 g Dry
Citrus reticulata Tangerine Fruit 100 g Fresh
15 g Dry
Citrus sinensis Sweet orange Fruit 100 g Fresh
15 g Dry
Coccinia grandis Ivy gourd Fruit 100 g Fresh
10 g Dry
Cocos nucifera Coconut Fruit 20 g Fresh
10 g Dry
Coriandrum sativum Coriander Leaf 100 g Fresh
10 g Dry
Cucumis melo subsp. melo var. cantalupo Cantaloupe Fruit 100 g Fresh
10 g Dry
Cucumis sativus Cucumber Fruit 100 g Fresh
5 g Dry
Cucurbita maxima Winter squash Fruit 100 g Fresh
10 g Dry
Cucurbita moschata Butternut squash Fruit 100 g Fresh
15 g Dry
Seed 10 g Dry
Cucurbita pepo Pumpkin Fruit 100 g Fresh
5 g Dry
Cucurbita pepo var pepo Zucchini Fruit 100 g Fresh
5 g Dry
Cuminum cyminum Cumin Fruit 2 g Dry
Cydonia oblonga Quince Fruit 100 g Fresh
15 g Dry
Cymbopogon citratus Lemongrass
  • Herb top
  • Leaf
100 g Fresh
30 g Dry
Cynara cardunculus Artichoke Leaf As per NNHPD Globe artichoke monograph
Daucus carota Carrot
  • Root
  • Tuber
100 g Fresh
10 g Dry
Dioscorea alata Yam
  • Root
  • Tuber
100 g Fresh
30 g Dry
Diospyros virginiana American persimmon Fruit 100 g Fresh
35 g Dry
Elaeis guineensis Palm Oil Fruit 15 g of oil
Fagopyrum esculentum Buckweat Seed 20 g Dry
Ficus carica Fig Fruit 100 g Fresh
20 g Dry
Foeniculum vulgare subsp. vulgare var. dulce Sweet fennel Bulb 100 g Fresh
10 g Dry
Fragaria virginiana Wild strawberry Fruit 100 g Fresh
10 g Dry
Fragaria x ananassa Strawberry Fruit 100 g Fresh
10 g Dry
Garcinia mangostana Mangosteen Fruit 100 g Fresh
20 g Dry
Glycine max Soy Seed As per NNHPD Soy Flour Monograph
Sprout 20 g Fresh
5 g Dry
Haematococcus pluvialis Haematococcus pluvialis Whole 1 g Dry
Helianthus annuus Sunflower Seed 35 g Dry
Sunflower oil Seed As per NNHPD Multiple Ingredient Fixed Oil Products - Oral monograph
Hibiscus sabdariffa Sorrel Leaf 100 g Fresh
5 g Dry
Hippophae rhamnoides Sea buckthorn Fruit 30 g Fresh
5 g Dry
Hordeum vulgare Barley Grain 10 g Dry
Sprout 20 g Fresh
5 g Dry
Barleygrass
  • Herb top
  • Leaf
100 g Fresh
20 g Dry
Ipomoea batatas Sweet potato
  • Root
  • Tuber
100 g Fresh
20 g Dry
Juglans regia Walnut Seed 30 g Dry
Krill oil Krill oil
  • Euphausia pacifica - Whole
  • Euphausia superba - Whole
As per NNHPD Multiple Ingredient Fixed Oil Products - Oral monograph
Lactuca sativa Lettuce Leaf 100 g Fresh
5 g Dry
Lactuca sativa var. crispa Curled lettuce Leaf 100 g Fresh
5 g Dry
Lactuca sativa var. longifolia Romaine lettuce Leaf 100 g Fresh
5 g Dry
Lagenaria siceraria Calabash Fruit 100 g Fresh
5 g Dry
Lens culinaris Lentil Seed 100 g Cooked
30 g Cooked and Dried
Lepidium sativum Garden cress Leaf 100 g Fresh
20 g Dry
Linum usitatissimum Flax Sprout 20 g Fresh
5 g Dry
Lycium barbarum Goji Fruit 6 g Dry
Malpighia emarginata West Indian-cherry Fruit 100 g Fresh
10 g Dry
Malpighia glabra Acerola Fruit 100 g Fresh
10 g Dry
Malus domestica Apple Fruit 100 g Fresh
5 g Dry
Malus pumila Mill. Paradise apple Fruit 100 g Fresh
5 g Dry
Mangifera indica Mango Fruit 100 g Fresh
20 g Dry
Medicago sativa Alfalfa Herb top As per NNHPD Alfalfa Monograph
Morinda citrifolia Noni Fruit 10 g Dry
Moringa oleifera Moringa
  • Leaf
  • Seed
10 g Dry
Morus alba White mulberry Fruit 100 g Fresh
10 g Dry
Musa x paradisiaca Banana Fruit 100 g Fresh
25 g Dry
Myrciaria dubia Camu-camu Fruit 1.5 g Dry
Nasturtium officinale Watercress
  • Herb top
  • Leaf
100g Fresh
5 g Dry
Nelumbo nucifera Lotus Seed 100g Fresh
25 g Dry
Olea europaea Olive Fruit 100g Fresh
10 g Dry
Olive oil As per NNHPD Multiple Ingredient Fixed Oil Products - Oral monograph
Opuntia ficus-indica Prickly-pear Fruit 100 g Fresh
5 g Dry
Leaf 40 g Fresh
3 g Dry
Origanum vulgare Oregano Leaf 1.5 g Dry
Oryza sativa Rice
  • Seed
  • Seed bran
100 g Cooked
30 g Cooked and Dried
Palmaria palmata Dulse
  • Thallus
  • Whole
100 g Fresh
15 g Dry
Panicum miliaceum Millet Seed 100 g Cooked
30 g Cooked and Dried
Sprout 20 g Fresh
5 g Dry
Passiflora edulis Purple granadilla Fruit 100 g Fresh
25 g Dry
Passiflora quadrangularis Giant granadilla Fruit 100 g Fresh
5 g Dry
Pastinaca sativa Parsnip
  • Root
  • Tuber
100 g Fresh
20 g Dry
Persea americana Avocado Fruit 100 g Fresh
25 g Dry
Petroselinum crispum Parsley Herb top 40 g Fresh
5 g Dry
Phaseolus vulgaris White kidney bean Seed 100 g Cooked
35 g Cooked and Dried
Phoenix dactylifera Date Fruit 94 g Fresh
75 g Dry
Pimenta dioica Allspice Fruit 2 g Dry
Pimpinella anisum Anise Fruit 2 g Dry
Pinus pinaster Maritime pine Stem bark 200-450 mg of extract standardized to 65-75% procyanidins
Pisum sativum Pea Seed 100 g Fresh
20 g Dry
Porphyra yezoensis Nori
  • Thallus
  • Whole
20 g Fresh
3 g Dry
Prunus armeniaca Apricot Fruit 100 g Fresh
15 g Dry
Prunus avium Sweet cherry Fruit 100 g Fresh
20 g Dry
Prunus cerasus Sour cherry Fruit 100 g Fresh
15 g Dry
Prunus domestica Prune plum Fruit 100 g Fresh
15 g Dry
Prunus dulcis Almond Seed 35 g Dry
Prunus persica Peach Fruit 100 g Fresh
10 g Dry
Prunus persica var. nucipersica Nectarine Fruit 100 g Fresh
10 g Dry
Prunus serotina Black cherry Fruit 100 g Fresh
20 g Dry
Prunus virginiana Chokeberry Fruit 100 g Fresh
40 g Dry
Psidium guajava Guava Fruit 100 g Fresh
20 g Dry
Pyrus communis Pear Fruit 100 g Fresh
15 g Dry
Pyrus pyrifolia Chinese pear Fruit 100 g Fresh
10 g Dry
Raphanus sativus Radish
  • Root
  • Tuber
100 g Fresh
5 g Dry
Sprout 20 g Fresh
5 g dry
Ribes nigrum Black currant Fruit 100 g Fresh
20 g Dry
Ribes uva-crispa Gooseberry Fruit 100 g Fresh
10 g Dry
Rosa canina Dog rose Fruit 100 g Fresh
45 g Dry
Rosmarinus officinalis Rosemary Leaf As per NNHPD Rosemary - Oral Monograph
Rubus arcticus Arctic raspberry Fruit 100 g Fresh
10 g Dry
Rubus idaeus Raspberry Fruit 100 g Fresh
10 g Dry
Rubus occidentalis Black raspberry Fruit 100 g Fresh
10 g Dry
Rubus plicatus Blackberry Fruit 100 g Fresh
10 g Dry
Salvia hispanica Chia Seed 40 g Dry
Sprout 20 g Fresh
5 g Dry
Sesamum indicum Sesame Seed 35 g Dry
Setaria italica Italian millet Seed 100 g Cooked
30 g Cooked and Dried
Solanum lycopersicum Tomato Fruit 100 g Fresh
5 g Dry
Solanum tuberosum Potato
  • Root
  • Tuber
100 g Fresh
20 g Dry
Spinacia oleracea Spinach Leaf 100 g Fresh
10 g Dry
Syzygium aromaticum Clove Flower bud 2 g Dry
Tamarindus indica Tamarind Fruit 1.5 g Dry
Terminalia chebula Haritaki Fruit As per NNHPD Triphala Monograph
Trigonella foenum-graecum Fenugreek Seed As per NNHPD Fenugreek - Oral Monograph
Triticum aestivum Wheat Seed 10 g Dry
Sprout 20 g Fresh
5 g Dry
Wheatgrass
  • Herb top
  • Leaf
20 g Fresh
5 g Dry
Wheat germ oil Seed germ As per NNHPD Multiple Ingredient Fixed Oil Products - Oral monograph
Vaccinium myrsinites Shiny blueberry Fruit 100 g Fresh
15 g Dry
Vaccinium vitis-idaea Cowberry Fruit 100 g Fresh
15 g Dry
Vicia faba Fava-bean Fruit 100g Fresh
25 g Dry
Vigna radiata Mung-bean Seed 100 g Cooked
25 g Cooked and Dried
Vigna unguiculata subsp. cylindrica Catjang cowpea Seed 100 g Fresh
20 g Dry
Vitis labrusca Concord grape Fruit 100 g Fresh
20 g Dry
Vitis vinifera Grape Fruit 100 g Fresh
5 g Dry
Fruit skin 10 g Fresh
1 g Dry
Seed 5 g Fresh
0.5 g Dry
Zea mays Corn Seed 100 g Cooked
25 g Cooked and Dried
Zingiber officinale Ginger
  • Root
  • Rhizome
As per NNHPD Ginger Monograph
Ziziphus jujuba Jujube Fruit 100 g Fresh
10 g Dry

Appendix 4:

Fruit and/or vegetable or sprout blends. Footnote 1

Note that as indicated in the Natural Health Products Ingredients Database (NHPID), individual substances (i.e. plants) and their respective part(s) and quantities should appear on the label. Where this information is not present on the Product Licence Application (PLA) form (i.e. individual substances listed under "source material"), a cover letter listing the substances and associated information should accompany the PLA form. Each individual substance must be listed in the NHPID and be associated with a medicinal role.

Proper name(s) Common name(s) Source material(s) Maximum daily dose Footnote 2

Table 3 Footnotes

Table 3 Footnote 1

The following reference has been consulted :

NNHPD 2015

Return to Table 3 footnote 1 referrer

Table 3 Footnote 2

Acceptable methods of preparation: Dry, dry standardized, powder, powder standardized, extract dry, extract dry standardized, extract liquid, extract liquid standardized, fluid extract, fluid extract standardized, tincture, tincture standardized, decoction, decoction standardized, oil fixed, oil fixed standardized.

Return to Table 3 footnote 2 referrer

Fruit blend Fruit blend As per NHPID 1 g
Fruit and vegetable blend Fruit and vegetable powder As per NHPID 1 g
Sprout blend Sprout blend As per NHPID 1 g
Vegetable blend Vegetable blend As per NHPID 1 g